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01.06.2012

Effects of High-Dose Dexamethasone on Regulating Interleukin-22 Production and Correcting Th1 and Th22 Polarization in Immune Thrombocytopenia

verfasst von: Jiang Cao, Chong Chen, Li Li, Ling-yu Zeng, Zhen-yu Li, Zhi-ling Yan, Wei Chen, Hai Cheng, Wei Sang, Kai-lin Xu

Erschienen in: Journal of Clinical Immunology | Ausgabe 3/2012

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Abstract

Background

T-cell dysregulation and T-cell-related cytokine abnormalities are involved in the pathogenesis of immune thrombocytopenia (ITP). One of our previous studies showed that elevated IL-22 correlated to Th1 and Th22 cells plays an important role in the immunopathogenesis of ITP. In this study, we aimed to investigate the effects of high-dose dexamethasone (HD-DXM) on IL-22 production and on the IL-22-producing T-cell subsets in ITP patients.

Methods

IL-22 plasma levels and the percentages of Th1, Th17, and Th22 cells were determined by enzyme-linked immunosorbent assay and flow cytometry in 25 ITP patients receiving DXM 40 mg/day for 4 consecutive days.

Results

Plasma IL-22 concentrations and the percentages of Th1 and Th22 cells were significantly increased in pre-therapy patients relative to controls (P < 0.05), but the percentage of Th17 cells was not. HD-DXM administration reduced IL-22 production and corrected the imbalance between Th1 and Th22 subsets. IL-22 levels were positively correlated with Th1 and Th22 cells in ITP patients before and after HD-DXM treatment.

Conclusion

These results suggest that HD-DXM may regulate the production of IL-22 in ITP, possibly by correcting Th1 and Th22 polarization.

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Titel: Effects of High-Dose Dexamethasone on Regulating Interleukin-22 Production and Correcting Th1 and Th22 Polarization in Immune Thrombocytopenia
verfasst von: Jiang Cao
Chong Chen
Li Li
Ling-yu Zeng
Zhen-yu Li
Zhi-ling Yan
Wei Chen
Hai Cheng
Wei Sang
Kai-lin Xu
Publikationsdatum: 01.06.2012
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 3/2012
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-012-9649-4

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