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Brain Structure and Function

Erschienen in:

12.09.2017 | Original Article

Effects of PER3 clock gene polymorphisms on aging-related changes of the cerebral cortex

verfasst von: Delphine Dewandre, Mercedes Atienza, Mayely P. Sanchez-Espinosa, Jose L. Cantero

Erschienen in: Brain Structure and Function | Ausgabe 2/2018

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Abstract

Considerable evidence suggests that circadian rhythmicity is progressively disrupted in senescence. Among clock genes, Period3 (PER3) has been associated with circadian phenotypes, homeostatic regulation of sleep, and cognitive performance in young adults. However, the effects of PER3 genotype on aging-related changes in both cognitive function and cortical integrity remain largely unknown. To shed light into this issue, we have investigated differences in cognitive performance, patterns of cortical thickness, and cortical glucose consumption in normal elderly subjects homozygous carriers of the short (PER3^4/4, n = 32) and long repeat alleles (PER3^5/5, n = 32). Relationships between cognitive performance and cortical thickness/metabolism were further explored for each PER3 genotype. We found that PER3^5/5 carriers had poorer cognitive performance (attention, executive function, semantic memory, and verbal fluency) and lower cortical integrity (structural and functional) than PER3^4/4. PER3^5/5 further showed thinning of temporo–parietal areas, and reductions of glucose consumption in fronto–temporo–parietal regions bilaterally. Moreover, PER3^5/5 subjects exhibited significant correlations between decreased glucose metabolism in fronto–parietal regions and poorer cognitive flexibility, though only correlations with lower glucose consumption of the supramarginal gyrus distinguished PER3^5/5 from PER3^4/4 groups. Overall, these findings enhance our understanding on the gene–brain interaction in aging, and may have further implications for the detection of subclinical cognitive decline associated with PER3 genotypes in late life.

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Titel: Effects of PER3 clock gene polymorphisms on aging-related changes of the cerebral cortex
verfasst von: Delphine Dewandre
Mercedes Atienza
Mayely P. Sanchez-Espinosa
Jose L. Cantero
Publikationsdatum: 12.09.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 2/2018
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-017-1513-0

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