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06.03.2019 | Head and Neck

Effects of thalamic infarction on the structural and functional connectivity of the ipsilesional primary somatosensory cortex

verfasst von: Li Chen, Tianyou Luo, Kangcheng Wang, Yong Zhang, Dandan Shi, Fajin Lv, Yang Li, Yongmei Li, Qi Li, Weidong Fang, Zhiwei Zhang, Juan Peng, Hanfeng Yang

Erschienen in: European Radiology | Ausgabe 9/2019

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Abstract

Objectives

To identify regions causally influenced by thalamic stroke by measuring white matter integrity, cortical volume, and functional connectivity (FC) among patients with thalamic infarction (TI) and to determine the association between structural/functional alteration and somatosensory dysfunction.

Methods

Thirty-one cases with TI-induced somatosensory dysfunction and 32 healthy controls underwent magnetic resonance imaging scanning. We reconstructed the ipsilesional central thalamic radiation (CTR) and assessed its integrity using fractional anisotropy (FA), assessed S1 ipsilesional changes with cortical volume, and identified brain regions functionally connected to TI locations and regions without TI to examine the potential effects on somatosensory symptoms.

Results

Compared with controls, TI patients showed decreased FA (F = 17.626, p < 0.001) in the ipsilesional CTR. TI patients exhibited significantly decreased cortical volume in the ipsilesional top S1. Both affected CTR (r = 0.460, p = 0.012) and S1 volume (r = 0.375, p = 0.049) were positively correlated with somatosensory impairment in TI patients. In controls, the TI region was highly functionally connected to atrophic top S1 and less connected to the adjacent middle S1 region in FC mapping. However, T1 patients demonstrated significantly increased FC between the ipsilesional thalamus and middle S1 area, which was adjacent to the atrophic S1 region.

Conclusions

TI induces remote changes in the S1, and this network of abnormality underlies the cause of the sensory deficits. However, our other finding that there is stronger connectivity in pathways adjacent to the damaged ones is likely responsible for at least some of the recovery of function.

Key Points

• TI led to secondary impairment in the CTR and cortical atrophy in the ipsilesional top of S1.

• TI patients exhibited significantly higher functional connectivity with the ipsilateral middle S1 which was mainly located within the non-atrophic area of S1.

• Our results provide neuroimaging markers for non-invasive treatment and predict somatosensory recovery.

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Kessner SS, Bingel U, Thomalla G (2016) Somatosensory deficits after stroke: a scoping review. Top Stroke Rehabil 23:136–146CrossRefPubMed

Leoni RF, Paiva FF, Kang BT et al (2012) Arterial spin labeling measurements of cerebral perfusion territories in experimental ischemic stroke. Transl Stroke Res 3:44–55CrossRefPubMed

Feigenson JS, McCarthy ML, Greenberg SD, Feigenson WD (1977) Factors influencing outcome and length of stay in a stroke rehabilitation unit. Part 2. Comparison of 318 screened and 248 unscreened patients. Stroke 8:657–662CrossRefPubMed

Meyer S, Kessner SS, Cheng B et al (2016) Voxel-based lesion-symptom mapping of stroke lesions underlying somatosensory deficits. Neuroimage Clin 10:257–266

Preusser S, Thiel SD, Rook C et al (2015) The perception of touch and the ventral somatosensory pathway. Brain 138:540–548

Kim JH, Greenspan JD, Coghill RC, Ohara S, Lenz FA (2007) Lesions limited to the human thalamic principal somatosensory nucleus (ventral caudal) are associated with loss of cold sensations and central pain. J Neurosci 27:4995–5004CrossRefPubMed

Kishi M, Sakakibara R, Nagao T, Terada H, Ogawa E (2009) Thalamic infarction disrupts spinothalamocortical projection to the mid-cingulate cortex and supplementary motor area. J Neurol Sci 281:104–107CrossRefPubMed

Ohara S, Lenz FA (2001) Reorganization of somatic sensory function in the human thalamus after stroke. Ann Neurol 50:800–803CrossRefPubMed

Staines WR, Black SE, Graham SJ, McIlroy WE (2002) Somatosensory gating and recovery from stroke involving the thalamus. Stroke 33:2642–2651CrossRefPubMed

10.

Lee MY, Kim SH, Choi BY, Chang CH, Ahn SH, Jang SH (2012) Functional MRI finding by proprioceptive input in patients with thalamic hemorrhage. NeuroRehabilitation 30:131–136PubMed

11.

Kunimatsu A, Aoki S, Masutani Y, Abe O, Mori H, Ohtomo K (2003) Three-dimensional white matter tractography by diffusion tensor imaging in ischaemic stroke involving the corticospinal tract. Neuroradiology 45:532–535CrossRefPubMed

12.

Lee JS, Han MK, Kim SH, Kwon OK, Kim JH (2005) Fiber tracking by diffusion tensor imaging in corticospinal tract stroke: topographical correlation with clinical symptoms. Neuroimage 26:771–776CrossRefPubMed

13.

Stinear CM, Barber PA, Smale PR, Coxon JP, Fleming MK, Byblow WD (2007) Functional potential in chronic stroke patients depends on corticospinal tract integrity. Brain 130:170–180CrossRefPubMed

14.

Maguire EA, Gadian DG, Johnsrude IS, et al (2000) Navigation-related structural change in the hippocampi of taxi drivers. Proc Natl Acad Sci U S A 97:4398–4403

15.

Seghier ML, Ramsden S, Lim L, Leff AP, Price CJ (2014) Gradual lesion expansion and brain shrinkage years after stroke. Stroke 45:877–879CrossRefPubMed

16.

Barkhof F, Haller S, Rombouts SA (2014) Resting-state functional MR imaging: a new window to the brain. Radiology 272:29–49CrossRef

17.

Liu J, Qin W, Zhang J, Zhang X, Yu C (2015) Enhanced interhemispheric functional connectivity compensates for anatomical connection damages in subcortical stroke. Stroke 46:1045–1051CrossRefPubMed

18.

Dijkhuizen RM, Zaharchuk G, Otte WM (2014) Assessment and modulation of resting-state neural networks after stroke. Curr Opin Neurol 27:637–643CrossRefPubMed

19.

Lindmark B, Hamrin E (1988) Evaluation of functional capacity after stroke as a basis for active intervention. Presentation of a modified chart for motor capacity assessment and its reliability. Scand J Rehabil Med 20:103–109PubMed

20.

Fugl-Meyer AR, Jääskö L, Leyman I, Olsson S, Steglind S (1975) The post-stroke hemiplegic patient. 1. A method for evaluation of physical performance. Scand J Rehabil Med 7:13–31

21.

Chen L, Luo T, Lv F et al (2016) Relationship between hippocampal subfield volumes and memory deficits in patients with thalamus infarction. Eur Arch Psychiatry Clin Neurosci 266:543–555CrossRefPubMed

22.

Wilkinson M, Kane T, Wang R, Takahashi E (2016) Migration pathways of thalamic neurons and development of thalamocortical connections in humans revealed by diffusion MR tractography. Cereb Cortex 27:5683–5695

23.

Wang D, Buckner RL, Liu H (2014) Functional specialization in the human brain estimated by intrinsic hemispheric interaction. J Neurosci 34:12341–12352CrossRefPubMedPubMedCentral

24.

Preacher KJ, Hayes AF (2008) Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods 40:879–891CrossRefPubMed

25.

Behrens TE, Johansen-Berg H, Woolrich MW et al (2003) Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci 6:750–757

26.

Silasi G, Murphy TH (2014) Stroke and the connectome: how connectivity guides therapeutic intervention. Neuron 83:1354–1368CrossRefPubMed

27.

Yoon H, Kim J, Moon WJ et al (2017) Characterization of chronic axonal degeneration using diffusion tensor imaging in canine spinal cord injury: a quantitative analysis of diffusion tensor imaging parameters according to histopathological differences. J Neurotrauma 34:3041–3050

28.

Cheng B, Schulz R, Bönstrup M et al (2015) Structural plasticity of remote cortical brain regions is determined by connectivity to the primary lesion in subcortical stroke. J Cereb Blood Flow Metab 35:1507–1514

29.

Duering M, Righart R, Csanadi E et al (2012) Incident subcortical infarcts induce focal thinning in connected cortical regions. Neurology 79:2025–2028

30.

Duering M, Righart R, Wollenweber FA, Zietemann V, Gesierich B, Dichgans M (2015) Acute infarcts cause focal thinning in remote cortex via degeneration of connecting fiber tracts. Neurology 84:1685–1692CrossRefPubMedPubMedCentral

31.

Zhang J, Meng L, Qin W, Liu N, Shi FD, Yu C (2014) Structural damage and functional reorganization in ipsilesional m1 in well-recovered patients with subcortical stroke. Stroke 45:788–793CrossRefPubMed

32.

Carter AR, Astafiev SV, Lang CE et al (2010) Resting interhemispheric functional magnetic resonance imaging connectivity predicts performance after stroke. Ann Neurol 67:365–375

33.

Park CH, Chang WH, Ohn SH et al (2011) Longitudinal changes of resting-state functional connectivity during motor recovery after stroke. Stroke 42:1357–1362

34.

Hartwigsen G, Saur D (2017) Neuroimaging of stroke recovery from aphasia - insights into plasticity of the human language network. Neuroimage S1053–8119:31000–31005

35.

Grefkes C, Fink GR (2014) Connectivity-based approaches in stroke and recovery of function. Lancet Neurol 13:206–216CrossRefPubMed

36.

Grefkes C, Ward NS (2014) Cortical reorganization after stroke: how much and how functional. Neuroscientist 20:56–70CrossRefPubMed

37.

Thiel A, Vahdat S (2015) Structural and resting-state brain connectivity of motor networks after stroke. Stroke 46:296–301CrossRefPubMed

38.

Weder B, Knorr U, Herzog H et al (1994) Tactile exploration of shape after subcortical ischaemic infarction studied with PET. Brain 117(Pt 3):593–605

39.

Carmichael ST (2006) Cellular and molecular mechanisms of neural repair after stroke: making waves. Ann Neurol 59:735–742CrossRefPubMed

40.

Carmichael ST (2008) Themes and strategies for studying the biology of stroke recovery in the poststroke epoch. Stroke 39:1380–1388CrossRefPubMedPubMedCentral

41.

Wu T, Hallett M (2013) The cerebellum in Parkinson’s disease. Brain 136:696–709CrossRefPubMed

42.

Zhang D, Snyder AZ, Shimony JS, Fox MD, Raichle ME (2010) Noninvasive functional and structural connectivity mapping of the human thalamocortical system. Cereb Cortex 20:1187–1194CrossRefPubMed

43.

Arcaro MJ, Pinsk MA, Kastner S (2015) The anatomical and functional organization of the human visual pulvinar. J Neurosci 35:9848–9871CrossRefPubMedPubMedCentral

44.

Lam TK, Dawson DR, Honjo K et al (2018) Neural coupling between contralesional motor and frontoparietal networks correlates with motor ability in individuals with chronic stroke. J Neurol Sci 384:21–29CrossRefPubMed

Titel: Effects of thalamic infarction on the structural and functional connectivity of the ipsilesional primary somatosensory cortex
verfasst von: Li Chen
Tianyou Luo
Kangcheng Wang
Yong Zhang
Dandan Shi
Fajin Lv
Yang Li
Yongmei Li
Qi Li
Weidong Fang
Zhiwei Zhang
Juan Peng
Hanfeng Yang
Publikationsdatum: 06.03.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 9/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-019-06068-0

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Effects of thalamic infarction on the structural and functional connectivity of the ipsilesional primary somatosensory cortex

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Abstract

Objectives

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