nach oben

Erschienen in:

25.04.2016 | Original Article

Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study

verfasst von: Božidar Brković, Miroslav Andrić, Dejan Ćalasan, Marija Milić, Jelena Stepić, Milan Vučetić, Denis Brajković, Ljubomir Todorović

Erschienen in: Clinical Oral Investigations | Ausgabe 3/2017

Einloggen, um Zugang zu erhalten

Abstract

Objectives

The purpose of this study was to investigate postoperative analgesic effect of ropivacaine administered as main or supplemental injection for the inferior alveolar nerve block (IANB) in patients undergoing lower third molar surgery.

Materials and Methods

The double-blind randomized study comprised 72 healthy patients. All patients received two blocks, the IANB for surgical procedure + IANB after surgery for postoperative pain control, and were divided into three groups: (1) 2 % lidocaine/epinephrine + 1 % ropivacaine, (2) 2 % lidocaine/epinephrine + saline, and (3) 1 % ropivacaine + saline. The occurrence of postoperative pain, pain intensity and analgesic requirements were recorded. Data were statistically analyzed using chi-square, Fisher, and Kruskal-Wallis tests and analysis of variance (ANOVA) with Bonferroni and Tukey correction.

Results

Ropivacaine was more successful than lidocaine/epinephrine in obtaining duration of postoperative analgesia, reduction of pain, and analgesic requirements whether ropivacaine was used for surgical block or administered as a supplemental injection after surgery.

Conclusions

Ropivacaine (1 %, 2 ml) resulted in effective postoperative analgesia after lower third molar surgery.

Clinical Relevance

Since pain control related to third molar surgery requires the effective surgical anesthesia and postoperative analgesia, the use of 1 % ropivacaine could be clinically relevant in a selection of appropriate pain control regimen for both surgical procedure and early postsurgical treatment.

Fisher SE, Frame JW, Rout PGJ, McEntegart DJ (1988) Factors affecting the onset and severity of pain following the surgical removal of unilateral impacted mandibular third molar teeth. Br Dent J 164:351–354CrossRefPubMed

Shapiro RD, Cohen BH (1992) Perioperative pain control. Oral Maxillofac Clin N Am 4:663–664

Caruso JM, Brokaw WC, Blanton EE (1989) Bupivacaine and lidocaine compared for postoperative pain control. Gen Dent 37:148–151PubMed

Chapman PJ (1988) A controlled comparison of effectiveness of bupivacaine for post-operative pain control. Aust Dent J 33:288–290CrossRefPubMed

McClure JH (1996) Ropivacaine. Br J Anaesth 76:300–307CrossRefPubMed

Junca A, Marret E, Goursot G, Mazoit X, Bonnet F (2001) A Comparison of ropivacaine and bupivacaine for cervical plexus block. Anesth Analg 92:720–724CrossRefPubMed

Beilin Y, Galea M, Zahn J, Bodian CA (1999) Epidural ropivacaine for the initiation of labor epidural analgesia: a dose finding study. Anesth Analg 88:1340–1345CrossRefPubMed

McClellen KJ, Faulds D (2000) Ropivacaine: an update of its use in regional anaesthesia. Drugs 60:1065–1073CrossRef

Whiteside JB, Wildsmith JAW (2001) Developments in local anaesthesia drugs. Br J Anaesth 87:27–35CrossRefPubMed

10.

Klein SM, Greengrass RA, Steele SM, D’Ercole FJ, Speer KP, Gleason DH, DeLong ER, Warner DS (1998) A Comparison of 0.5% bupivacaine, 0.5% ropivacaine, and 0.75% ropivacaine for interscalene brachial plexus blocks. Anesth Analg 87:1316–1319PubMed

11.

Hickey R, Hoffman J, Ramamurthy S (1991) A comparison of ropivacaine 0.5% and bupivacaine 0.5% for brachial plexus block. Anesthesiology 74:639–642CrossRefPubMed

12.

Fibla JJ, Molins L, Mier JM, Sierra A, Vidal G (2008) Comparative analysis of analgesic quality in the postoperative of thoracotomy: paravertebral block with bupivacaine 0.5% vs ropivacaine 0.2%. Eur J Cardiothorac Surg 33:430–434CrossRefPubMed

13.

Anantanarayanan P, Raja DK, Kumar JN, Sneha P, Christabel A, Manikandhan R, Elavazhagan N (2013) Catheter-based donor site analgesia after rib grafting: a prospective, randomized, double-blinded clinical trial comparing ropivacaine and bupivacaine. J Oral Maxillofac Surg 71:29–34CrossRefPubMed

14.

Korula S, Grace Maria G, Shaloo I, Saramma AP (2011) Epidural anesthesia and post-operative analgesia for bilateral inguinal mesh hernioplasty: comparison of equipotent doses of ropivacaine and bupivacaine. Saudi J Anaesth 5:277–281CrossRefPubMedPubMedCentral

15.

Sanders RD, Mallory S, Lucas DN, Chan T, Yeo S, Yentis SM (2004) Extending low-dose epidural analgesia for emergency Caesarean section using ropivacaine 0.75%. Anaesthesia 59:988–992CrossRefPubMed

16.

Ernberg M, Kopp S (2002) Ropivacaine for dental anesthesia: a dose-finding study. J Oral Maxillofac Surg 60:1004–1010CrossRefPubMed

17.

Kennedy M, Reader A, Beck M, Weaver J (2001) Anesthetic efficacy of ropivacaine in maxillary anterior infiltration. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:406–412CrossRefPubMed

18.

Meechan JG (2002) A comparison of ropivacaine and lidocaine with epinephrine for intraligamentary anesthesia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:469–473CrossRefPubMed

19.

Axelsson S, Isacsson G (2004) The efficacy of ropivacaine as a dental local anaesthetic. Swed Dent J 28:85–91PubMed

20.

Krzeminski TF, Gilowski L, Wiench R, Plocica I, Kondzielnik P, Sielanczyk A (2011) Comparison of ropivacaine and articaine with epinephrine for infiltration anaesthesia in dentistry—a randomized study. Int Endod J 44:746–751CrossRefPubMed

21.

Buric N (2006) The assessment of anesthetic efficacy of ropivacaine in oral surgery. N Y State Dent J 72:36–39PubMed

22.

El-Sharrawy E, Yagiela JA (2006) anesthetic efficacy of different ropivacaine concentrations for inferior alveolar nerve block. Anesth Prog 53:3–7CrossRefPubMedPubMedCentral

23.

Brkovic BMB, Zlatkovic M, Jovanovic D, Stojic D (2010) Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery. Int J Oral Maxillofac Surg 39:36–41CrossRefPubMed

24.

Budharapu A, Sinha R, Uppada UK, Subramanya Kumar AVSS (2015) Ropivacaine: a new local anaesthetic agent in maxillofacial surgery. Br J Oral Maxillofac Surg 53:451–454CrossRefPubMed

25.

Malamed SF (2004) Local anesthetic considerations in dental specialties. In: Malamed SF (ed) Handbook of local anesthesia, 5th edn. Mosby, St. Louis, p 277

26.

Danielsson K, Evers H, Nordenram A (1985) Long-acting local anesthetics in oral surgery: an experimental evaluation of bupivacaine and etidocaine for oral infiltration anesthesia. Anesth Prog 32:65–68PubMedPubMedCentral

27.

Brajkovic D, Brkovic B, Milic M, Biocanin V, Krsljak E, Stojic D (2014) Levobupivacaine vs. bupivacaine for third molar surgery: quality of anaesthesia, postoperative analgesia and local vascular effects. Clin Oral Investig 18:1481–1488. doi:10.1007/s00784-013-1114-0 CrossRefPubMed

28.

Casati A, Fanelli G, Aldegheri G, Berti M, Colnaghi E, Cedrati V, Torri G (1999) Interscalene brachial plexus anaesthesia with 0.5%, 0.75% or 1% ropivacaine. a double blind comparison with 2% mepivacaine. Br J Anaesth 83:872–875CrossRefPubMed

29.

Coghlan JA, Forbes A, McKenzi D, Bell SN, Buchbinder R (2009) Efficacy of subacromial ropivacaine infusion for rotator cuff surgery. J Bone Joint Surg Am 91:1558–1567CrossRefPubMed

30.

Coban YK, Senoglu N, Oksuz H (2008) Effect of preoperative local ropivacaine infiltration on postoperative pain scores in infants and small children undergoing elective cleft palate repair. J Craniofac Surg 19:1221–1224CrossRefPubMed

31.

Hillerup S, Jensen R (2006) Nerve injury caused by mandibular block analgesia. Int J Oral Maxillofac Surg 35:437–443. doi:10.1016/j.ijom.2005.10.004 CrossRefPubMed

32.

Morris C, Rasmussen J, Throckmorton GS, Finn R (2010) The anatomic basis of lingual nerve trauma associated with inferior alveolar block injections. J Oral Maxillofac Surg 68:2833–2836. doi:10.1016/j.joms.2010.06.193 CrossRefPubMed

33.

Kimi H, Yamashiro M, Hashimoto S (2012) The local pharmacokinetics of ³H-ropivacaine and ¹⁴C-lidocaine after maxillary infiltration anesthesia in rats. Anesth Prog 59:75–81CrossRefPubMedPubMedCentral

34.

Crincoli V, Di Bisceglie MB, Massaro M, Giuliano R, Favia G, Brienza N (2009) Postoperative pain relief after surgical removal of impacted third molars: a single-blind, randomized, controlled study to compare levobupivacaine and mepivacaine. J Orofac Pain 23:325–329PubMed

35.

Rood JP, Snowdon AT, Gennery BA (2002) Safety and efficacy of levobupivacaine for postoperative pain relief after surgical removal of impacted third molars: a comparison with lignocaine and adrenaline. Br J Oral Maxillofac Surg 40:491–496. doi:10.1016/S0266-4356(02)00184-5 CrossRefPubMed

36.

Cline E, Franz D, Polley RD, Moye J, Burkard J, Pellegrini J (2004) Analgesia and effectiveness of levobupivacaine compared with ropivacaine in patients undergoing an axillary brachial plexus block. AANA Jorunal 72:339–345

37.

Casati A, Jacques EC, Cerchierini E, Santorsola R, Nobili F, Grispigni C, Di Benedetto P, Torri G (2002) Clinical properties of levobupivacaine or racemic bupivacaine for sciatic nerve block. J Clin Anesth 14:111–114CrossRefPubMed

38.

Polley LS, Columb MO, Naughton NN, Wagner DS, van de Ven CJ (1999) Relative analgesic potencis of ropivacaine and bupivacaine for epidural analgesia in labour. Anesthesiology 90:944–950CrossRefPubMed

39.

Liisanantti O, Luukkonen J, Rosenberg PH (2004) High-dose bupivacaine, levobupivacaine and ropivacaine in axillary brachial plexus block. Acta Anaesthesiol Scand 48:601–606CrossRefPubMed

40.

Casati A, Borghi B, Fanelli G, Montone N, Rotini R, Fraschini G, Vinciguerra V, Torri G, Chelly J (2003) Intersclene brachial plexsus anesthesia and analgesia for open shoulder surgery: a randomized double-blinded comparison between levobupivacaine and ropivacaine. Anesth Analg 96:253–259PubMed

41.

Timponi CF, Oliveira NE, Arruda RMP, Meyrelles SS, Vasquez EC (2006) Effects of the local anaesthetic ropivacaine on vascular reactivity in the mouse perfused mesenteric arteries. Basic Clin Pharmacol Toxicol 98:518–520CrossRefPubMed

42.

Moffitt DL, de Berker DAR, Kennedy CTK, Shutt LE (2001) Assessment of ropivacaine as a local anesthetic for skin infiltration in skin surgery. Dermatol Surg 27:437–440PubMed

43.

Oliveira NE, Lima Filho NS, Lima EG, Vasquez EC (2006) Effects of regional anesthesia with ropvacaine on arterial pressure and heart rate in healithy subjects. Eur J Oral Sci 114:27–32CrossRefPubMed

Titel: Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study
verfasst von: Božidar Brković
Miroslav Andrić
Dejan Ćalasan
Marija Milić
Jelena Stepić
Milan Vučetić
Denis Brajković
Ljubomir Todorović
Publikationsdatum: 25.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 3/2017
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-016-1831-2

Neu im Fachgebiet Zahnmedizin

19.04.2024 | Vorhofflimmern | Nachrichten

Newsletter bestellen

Springer Medizin

Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study

Abstract

Objectives

Materials and Methods

Results

Conclusions

Clinical Relevance

Neu im Fachgebiet Zahnmedizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Invasive Zahnbehandlung: Wann eine Antibiotikaprophylaxe vor infektiöser Endokarditis schützt

Zell-Organisatoren unter Druck: Mechanismen des embryonalen Zahnwachstums aufgedeckt

Die Oralprophylaxe & Kinderzahnheilkunde umbenannt

Newsletter

Springer Medizin

Abstract

Objectives

Materials and Methods

Results

Conclusions

Clinical Relevance

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2017

Osteogenic gene array of osteoblasts cultured on a novel osteoinductive biphasic calcium phosphate bone grafting material

Responsiveness of the Prosthetic Esthetic Scale

Long-term effect of periodontal surgery on oral health and metabolic control of diabetics

Longevity and associated risk factors in adhesive restorations of young permanent teeth after complete and selective caries removal: a retrospective study

Comparative evaluation of the retaining of QMix and chlorhexidine formulations on human dentin: a chemical analysis

Does Botulinum neurotoxin type A treatment for sialorrhea change oral health?

Neu im Fachgebiet Zahnmedizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Invasive Zahnbehandlung: Wann eine Antibiotikaprophylaxe vor infektiöser Endokarditis schützt

Zell-Organisatoren unter Druck: Mechanismen des embryonalen Zahnwachstums aufgedeckt

Die Oralprophylaxe & Kinderzahnheilkunde umbenannt

Newsletter