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01.12.2014 | Meeting abstract | Sonderheft 1/2014 Open Access

The Journal of Headache and Pain 1/2014

EHMTI-0079. Reduced volume of anterior thalamic nuclei in migraineurs

The Journal of Headache and Pain > Sonderheft 1/2014
S Magon, A May, A Stankewitz, PJ Goadsby, AR Tso, M Ashina, FM Amin, CL Seifert, M Chakravarty, J Müller, T Sprenger


Previous studies on small samples of migraineurs have suggested subtle abnormalities of thalamic anatomy and function.


To study changes of thalamic volume and shape in a large cohort of migraineurs using a novel label-fusion based segmentation approach.


High-resolution 3D T-weighted MRI data were acquired at 3T in 131 migraineurs (31±9 years old; 109 women; monthly attack frequency: 3.2± 2.5; disease duration: 14±8.4 years) and 115 matched healthy subjects (29±7 years old; 81 women) at four international centers. The thalamus and thalamic subnuclei were segmented using a fully-automated multi-atlas approach. Deformation-based shape analysis was performed to localize thalamic surface abnormalities. To investigate group effects, ANCOVA was used (age, gender, site and brain volume as nuisance covariates; results were FDR corrected for multiple comparisons at threshold of 0.05.


We found volume reductions of the anterior, central, lateral dorsal (all FDR p<0.05) and a trend in the lateral posterior nucleus (FDR p<0.1) in migraineurs compared to controls. Patients with MwoA had by trend smaller volumes of anterior, central and lateral dorsal (all FDR<0.1) nuclei compared to controls. No significant differences were observed in patients with MwA compared with controls. No thalamic surface changes (shape analysis) and no relationship between thalamic volumes and migraine disorder duration or headache frequency was observed.


The thalamic nuclei with abnormal volumes are densely connected to the limbic system. The data hence lend support to the view that higher-order integration systems are altered in migraine. No abnormalities were found in classical somatosensory nuclei.
No conflict of interest.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( https://​creativecommons.​org/​licenses/​by/​4.​0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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