Introduction
Methods
No. | Name of the study | Journal | Quality Score |
---|---|---|---|
1 | Identifying Patients at Risk of Early Postoperative Recurrence of Lung Cancer: A New Use of the Old CEA Test | Ann Thorac Surg | Good |
2 | Predictive factors for node metastasis in patients with clinical stage I non-small cell lung cancer | Annals of Thoracic Surgery | Poor |
3 | Risk Factors for Predicting Occult Lymph Node Metastasis in Patients with Clinical Stage I Non-small Cell Lung Cancer Staged by Integrated Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography | World Journal of Surgery | Good |
4 | Optimal Predictive Value of Preoperative Serum Carcinoembryonic Antigen for Surgical Outcomes in Stage I Non-Small Cell Lung Cancer: Differences According to Histology and Smoking Status | Journal of Surgical Oncology | Fair |
5 | Clinical significance of preoperative carcinoembryonic antigen level for clinical stage I non-small cell lung cancer: can preoperative carcinoembryonic antigen level predict pathological stage? | Interactive CardioVascular and Thoracic Surgery | Good |
6 | Predictive Risk Factors for Mediastinal Lymph Node Metastasis in Clinical Stage IA Non–Small-Cell Lung Cancer Patients | Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer | Fair |
7 | Sialyl Lewis X as a predictor of skip N2 metastasis in clinical stage IA non-small cell lung cancer | World Journal of Surgical Oncology | Good |
8 | Clinical significance of preoperative carcinoembryonic antigen level in patients with clinical stage IA non-small cell lung cancer | J Thorac Dis | Good |
9 | Prognostic impact of Cyfra21–1 and other serum markers in completely resected non-small cell lung cancer | Lung Cancer | Good |
10 | Significant correlation between urinary N1, N12-diacetylspermine and tumor invasiveness in patients with clinical stage IA non-small cell lung cancer | BMC Cancer | Poor |
11 | Prediction of lymph node status in clinical stage IA squamous cell carcinoma of the lung | European Journal of Cardio-Thoracic Surgery | Good |
12 | Predictive Factors for Lymph Node Metastasis in Clinical Stage IA Lung Adenocarcinoma | Annals of Thoracic Surgery | Poor |
Results
Study selection
Basic demographics
Number of patients | 4666 |
---|---|
Male | 2602 |
Female | 2064 |
Age (mean) | 65.3 ± 3.2 years |
Smoking status | |
Smoker | 2003 |
Non-smoker | 1839 |
Not specified | 824 |
Histological types | |
Adenocarcinoma | 3622 |
Squamous cell cancer | 697 |
Large cell cancer | 54 |
Adenosquamous carcinoma | 17 |
Carcinoid tumor | 12 |
Others | 264 |
Follow up (mean) | 48.86 months |
Country | |
Japan | 8 |
China | 1 |
Korea | 1 |
Germany | 1 |
Italy | 1 |
Reporting of tumor markers and tumor characteristics
Low CEA | High CEA | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
NO | Author | Year of publication | No. of patients | CEA cut-off | No. of LN | 5 year survival | Recurrence | No. of LN | 5 year survival | Recurrence |
1 | Ryo Maeda [29] | 2017 | 378 | 5 ng/mL | 263 N0, 15 N1–3 | 87.70% | 81 N0, 19 N1–3 | 75.50% | ||
2 | Yusuke Takahashi [30] | 2015 | 171 | 5 ng/mL | ||||||
3 | Gianfranco Buccheri [18] | 2003 | 118 | 10 ng/mL | 16% | 70% | ||||
4 | Riken Kawachi [31] | 2009 | 815 | 5 ng/mL | 76.70% | 56.60% | ||||
5 | Niels Reinmuth [19] | 2002 | 67 | 5 ng/mL | ||||||
6 | Sukki Cho [32] | 2013 | 770 | 3.5 ng/mL (mean) | ||||||
7 | Kaoru Kaseda [33] | 2016 | 246 | 5 ng/mL | 168 N0, 19 N1-N2 | 47 N0, 12 N1-N2 | ||||
8 | Tatsuya Kato [34] | 2013 | 177 | 3 ng/mL | 93.2% (ADC), 81% (SCC) | 6.80% | 59.4% (ADC), 51.9% (SCC) | 38.80% | ||
9 | Terumoto Koike [35] | 2012 | 894 | 5 ng/mL | ||||||
10 | Hiroaki Komatsu [36] | 2013 | 279 | 2.8 ng/mL | 87 N0, 1 skip N2 | 143 N0, 11 skip N2 | ||||
11 | Yasuhiro Tsutani [37] | 2014 | 100 | 2.5 ng/mL | ||||||
12 | Bo Ye [38] | 2014 | 651 | 5 ng/mL | 371 N0, 11 N1, 8 N2 | 211 N0, 32 N1,18 N2 |