Skip to main content
Erschienen in: Clinical Journal of Gastroenterology 2/2012

01.04.2012 | Case Report

Elevation of carcinoembryonic antigen coinciding with disease activity of ulcerative colitis

verfasst von: Sayaka Yamaguchi, Yoshiaki Takeuchi, Katsuhito Arai, Chitose Oishi, Tomoko Norose, Toshiko Yamochi-Onizuka, Miki Kushima, Hidekazu Ota, Michio Imawari

Erschienen in: Clinical Journal of Gastroenterology | Ausgabe 2/2012

Einloggen, um Zugang zu erhalten

Abstract

We report on three cases of ulcerative colitis who presented with increased levels of serum carcinoembryonic antigen (CEA) during the active stage. All cases were pancolitis with a moderate to severe disease course. After remission induction with medical therapies, serum CEA levels decreased to the normal reference range. Immunohistochemical analyses demonstrated the existence of CEA not only along with the apical surface of the colonic epithelia but also at the cytosol of the inflamed epithelia where goblet cells were depleted during the active stage. We speculate that CEA was up-regulated by inflammatory response particularly in the process of epithelial regeneration.
Literatur
1.
Zurück zum Zitat Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell. 1989;57:327–34.PubMedCrossRef Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell. 1989;57:327–34.PubMedCrossRef
2.
Zurück zum Zitat Hammarström S, Olsen A, Teglund S. The nature and expression of the human CEA family. In: Stanners C, editor. Cell adhesion and communication mediated by the CEA family: basic and clinical perspectives. Amsterdam: Harwood Academic Publishers; 1997. p. 1–30. Hammarström S, Olsen A, Teglund S. The nature and expression of the human CEA family. In: Stanners C, editor. Cell adhesion and communication mediated by the CEA family: basic and clinical perspectives. Amsterdam: Harwood Academic Publishers; 1997. p. 1–30.
3.
Zurück zum Zitat Gold P, Freedman SO. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med. 1965;121:439–62.PubMedCrossRef Gold P, Freedman SO. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med. 1965;121:439–62.PubMedCrossRef
4.
Zurück zum Zitat Takimoto A, Aida Y, Sugita A, Harada H, Yamamoto M, Ishiguro N, et al. Serum CEA value in patients with ulcerative colitis. Jpn J Gastroenterol Surg. 1992;25:508 (in Japanese). Takimoto A, Aida Y, Sugita A, Harada H, Yamamoto M, Ishiguro N, et al. Serum CEA value in patients with ulcerative colitis. Jpn J Gastroenterol Surg. 1992;25:508 (in Japanese).
5.
Zurück zum Zitat Yan Z, Robinson-Saddler A, Winawer S, Friedman E. Colon carcinoma cells blocked in polarization exhibit increased expression of carcinoembryonic antigen. Cell Growth Differ. 1993;4:785–92.PubMed Yan Z, Robinson-Saddler A, Winawer S, Friedman E. Colon carcinoma cells blocked in polarization exhibit increased expression of carcinoembryonic antigen. Cell Growth Differ. 1993;4:785–92.PubMed
6.
7.
Zurück zum Zitat Fahlgren A, Baranov V, Frängsmyr L, Zoubir F, Hammarström M-L, Hammarström S. Interferon-gamma tempers the expression of carcinoembryonic antigen family molecules in human colon cells: a possible role in innate mucosal defence. Scand J Immunol. 2003;58:628–41.PubMedCrossRef Fahlgren A, Baranov V, Frängsmyr L, Zoubir F, Hammarström M-L, Hammarström S. Interferon-gamma tempers the expression of carcinoembryonic antigen family molecules in human colon cells: a possible role in innate mucosal defence. Scand J Immunol. 2003;58:628–41.PubMedCrossRef
8.
Zurück zum Zitat Smithson JE, Warren BF, Young S, Pigott R, Jewell DP. Heterogeneous expression of carcinoembryonic antigen in the normal colon and upregulation in active ulcerative colitis. J Pathol. 1996;180:146–51.PubMedCrossRef Smithson JE, Warren BF, Young S, Pigott R, Jewell DP. Heterogeneous expression of carcinoembryonic antigen in the normal colon and upregulation in active ulcerative colitis. J Pathol. 1996;180:146–51.PubMedCrossRef
9.
Zurück zum Zitat Hauck W, Stanners CP. Transcriptional regulation of the carcinoembryonic antigen gene. Identification of regulatory elements and multiple nuclear factors. J Biol Chem. 1995;270:3602–10.PubMedCrossRef Hauck W, Stanners CP. Transcriptional regulation of the carcinoembryonic antigen gene. Identification of regulatory elements and multiple nuclear factors. J Biol Chem. 1995;270:3602–10.PubMedCrossRef
10.
Zurück zum Zitat Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushima T, Ohnishi Y, et al. Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction. Hum Mol Genet. 2007;16:630–9.PubMedCrossRef Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushima T, Ohnishi Y, et al. Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction. Hum Mol Genet. 2007;16:630–9.PubMedCrossRef
11.
Zurück zum Zitat Tran R, Kashmiri SVS, Kantor J, Greiner JW, Pestka S, Shively JE, et al. Correlation of DNA hypomethylation with expression of carcinoembryonic antigen in human colon carcinoma cells. Cancer Res. 1988;48:5674–9.PubMed Tran R, Kashmiri SVS, Kantor J, Greiner JW, Pestka S, Shively JE, et al. Correlation of DNA hypomethylation with expression of carcinoembryonic antigen in human colon carcinoma cells. Cancer Res. 1988;48:5674–9.PubMed
12.
Zurück zum Zitat Pufulete M, Emery PW, Sanders TAB. Folate, DNA methylation and colo-rectal cancer. Proc Nutr Soc. 2003;62:437–45.PubMedCrossRef Pufulete M, Emery PW, Sanders TAB. Folate, DNA methylation and colo-rectal cancer. Proc Nutr Soc. 2003;62:437–45.PubMedCrossRef
13.
Zurück zum Zitat Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001;48:526–35.PubMedCrossRef Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001;48:526–35.PubMedCrossRef
14.
Zurück zum Zitat Askling J, Dickman PW, Karlén P, Broström O, Lapidus A, Löfberg R, et al. Family history as a risk factor for colon cancer in inflammatory bowel disease. Gastroenterology. 2001;120:1356–62.PubMedCrossRef Askling J, Dickman PW, Karlén P, Broström O, Lapidus A, Löfberg R, et al. Family history as a risk factor for colon cancer in inflammatory bowel disease. Gastroenterology. 2001;120:1356–62.PubMedCrossRef
15.
Zurück zum Zitat Guadagni F, Roselli M, Cosimelli M, Spila A, Cavaliere F, Arcuri R, et al. Quantitative analysis of CEA expression in colorectal adenocarcinoma and serum: lack of correlation. Int J Cancer. 1997;77:949–54.CrossRef Guadagni F, Roselli M, Cosimelli M, Spila A, Cavaliere F, Arcuri R, et al. Quantitative analysis of CEA expression in colorectal adenocarcinoma and serum: lack of correlation. Int J Cancer. 1997;77:949–54.CrossRef
Metadaten
Titel
Elevation of carcinoembryonic antigen coinciding with disease activity of ulcerative colitis
verfasst von
Sayaka Yamaguchi
Yoshiaki Takeuchi
Katsuhito Arai
Chitose Oishi
Tomoko Norose
Toshiko Yamochi-Onizuka
Miki Kushima
Hidekazu Ota
Michio Imawari
Publikationsdatum
01.04.2012
Verlag
Springer Japan
Erschienen in
Clinical Journal of Gastroenterology / Ausgabe 2/2012
Print ISSN: 1865-7257
Elektronische ISSN: 1865-7265
DOI
https://doi.org/10.1007/s12328-012-0285-6

Weitere Artikel der Ausgabe 2/2012

Clinical Journal of Gastroenterology 2/2012 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Positiver FIT: Die Ursache liegt nicht immer im Dickdarm

27.05.2024 Blut im Stuhl Nachrichten

Immunchemischer Stuhltest positiv, Koloskopie negativ – in solchen Fällen kann die Blutungsquelle auch weiter proximal sitzen. Ein Forschungsteam hat nachgesehen, wie häufig und in welchen Lokalisationen das der Fall ist.

GLP-1-Agonisten können Fortschreiten diabetischer Retinopathie begünstigen

24.05.2024 Diabetische Retinopathie Nachrichten

Möglicherweise hängt es von der Art der Diabetesmedikamente ab, wie hoch das Risiko der Betroffenen ist, dass sich sehkraftgefährdende Komplikationen verschlimmern.

Mehr Lebenszeit mit Abemaciclib bei fortgeschrittenem Brustkrebs?

24.05.2024 Mammakarzinom Nachrichten

In der MONARCHE-3-Studie lebten Frauen mit fortgeschrittenem Hormonrezeptor-positivem, HER2-negativem Brustkrebs länger, wenn sie zusätzlich zu einem nicht steroidalen Aromatasehemmer mit Abemaciclib behandelt wurden; allerdings verfehlte der numerische Zugewinn die statistische Signifikanz.

ADT zur Radiatio nach Prostatektomie: Wenn, dann wohl länger

24.05.2024 Prostatakarzinom Nachrichten

Welchen Nutzen es trägt, wenn die Strahlentherapie nach radikaler Prostatektomie um eine Androgendeprivation ergänzt wird, hat die RADICALS-HD-Studie untersucht. Nun liegen die Ergebnisse vor. Sie sprechen für länger dauernden Hormonentzug.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.