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Endocrine Pathology

Endocrine Pathology OnlineFirst articles

01.03.2019

Negative Results on Thyroid Molecular Testing Decrease Rates of Surgery for Indeterminate Thyroid Nodules

Molecular tests and mutational panels such as Afirma Gene Expression Classifier (GEC) and ThyroSeq, respectively, have been used to help risk stratify cytologically indeterminate thyroid nodules with the aim to reduce unnecessary surgeries. We …

16.02.2019

Neuroendocrine Neoplasms Associated with Germline Pathogenic Variants in the Homologous Recombination Pathway

Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of neoplasms that collectively have an annual incidence of 5.25 per 100,000 [ 1 ]. In two-thirds of cases, tumors arise from the neuroendocrine cells of the gastro-entero-pancreatic …

14.02.2019

MiRNA-3653 Is a Potential Tissue Biomarker for Increased Metastatic Risk in Pancreatic Neuroendocrine Tumours

Pancreatic neuroendocrine tumours (PNETs) are relatively uncommon, accounting for 1–2% of all pancreatic neoplasms. Tumour grade (based on the Ki67 proliferative index and mitotic rate) is associated with metastatic risk across large cohorts; …

31.01.2019

An Institutional Experience of Tumor Progression to Pituitary Carcinoma in a 15-Year Cohort of 1055 Consecutive Pituitary Neuroendocrine Tumors

Pituitary carcinoma is a rare disease, defined by the presence of cerebrospinal or distant metastasis of a pituitary neuroendocrine tumor (PitNET). To review our institutional experience of pituitary carcinoma, we searched the database of the UHN …

29.01.2019

Revisiting the Significance of Prominent C Cells in the Thyroid

C cell hyperplasia is considered a precursor lesion for hereditary forms of medullary thyroid carcinoma. It has therefore been suggested as a morphological marker to distinguish hereditary from sporadic medullary thyroid carcinoma and to triage …

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Endocrine Pathology publishes refereed original articles on clinical and basic aspects of endocrine disorders, focusing on the diagnostic aspects of endocrine pathology. Coverage includes book reviews, clinical case presentations, and descriptions of techniques. Particular attention is paid to new developments in the diagnostic applications of molecular biology and immunohistochemistry.

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