Background
Methods
Subjects
Group A (n = 5) | Group B (n = 6) | Group C (n = 6) | P value | |
---|---|---|---|---|
Age (years)
| 35.4 (26–43) | 41.9 (34–46) | 41.3 (36–47) | 0.1117 |
Body mass index
| 25.2 (22.6-29.4) | 25.6 (22.5-27.4) | 25.4 (23.3-28.1) | 0.573 |
Plasma progesterone* (nmol/L)
| 75.7 (38–122) | 88.1 (36–192) | 63.7 (43.3-75) | 0.7601 |
Endometrial thickness* (mm)
| 10.8 (9–12) | 9.1 (8–10) | 11.2 (8.5-12.5) | 0.6162 |
Induction of endometrial cycle
Gene expression profiling
Statistical analyses of microarrays data
Hierarchical clustering
Principal component analysis (PCA)
Functional clustering
DAVID
GATHER
Immunohistochemistry (IHC)
Antibody | Source | Dilution |
---|---|---|
Progesterone receptor (PR)-A/B | Santa Cruz Biotech. (sc-810) | 1:50 |
PR-B | Novocastra (NCL-PGR-B) | 1:100 |
Glycodelin | H. Koistinen [22] | 1:1000 |
Specificity protein-1 (Sp1) | Santa Cruz Biotech. (sc-14027) | 1:100 |
DNA isolation and PROGINSdetection
Results
Gene expression profile analysis
UniGene ID | Gene symbol | Gene title | A vs. B | p value | A vs. C | p value | Average |
---|---|---|---|---|---|---|---|
Hs.699841 | IGHA1 | Immunoglobulin heavy constant alpha 1 | 0.1 | 0.00086 | 0.08 | 0.00043 | 0.09 |
Hs.436657 | CLU | Clusterin | 0.11 | 0.00043 | 0.17 | 0.00013 | 0.14 |
Hs.356624 | NID1 | Nidogen 1 | 0.19 | 0.00013 | 0.14 | 0.00022 | 0.16 |
Hs.82071 | CITED2 | Cbp/p300-interacting transactivator. with Glu/Asp-rich carboxy-terminal domain. 2 | 0.15 | 0.00086 | 0.19 | 0.00043 | 0.17 |
Hs.532325 | PAEP | Progestagen-associated endometrial protein (PAEP) | 0.09 | 0.00086 | 0.29 | 0.00086 | 0.19 |
Hs.38972 | TSPAN1 | Tetraspanin 1 | 0.14 | 0.00022 | 0.24 | 0.00086 | 0.19 |
Hs.445705 | RRM1 | Ribonucleotide reductase M1 | 0.18 | 0.00043 | 0.23 | 0.00022 | 0.2 |
Hs.1012 | C4BPA | Complement component 4 binding protein. alpha | 0.21 | 0.00043 | 0.22 | 0.00043 | 0.22 |
Hs.513261 | HN1L | Hematological and neurological expressed 1-like | 0.18 | 0.00022 | 0.35 | 0.00043 | 0.26 |
Hs.80658 | UCP2 | Uncoupling protein 2 (mitochondrial. proton carrier) | 0.1 | 0.00043 | 0.49 | 0.00013 | 0.29 |
Hs.502989 | UNC93B1 | Unc-93 homolog B1 (C. elegans) | 0.23 | 0.00013 | 0.37 | 0.00043 | 0.3 |
Hs.414099 | CNPY3 | Canopy 3 homolog (zebrafish) | 0.29 | 0.00013 | 0.32 | 0.00022 | 0.31 |
Hs.110571 | GADD45B | Growth arrest and DNA-damage-inducible. beta | 0.2 | 0.00022 | 0.44 | 0.00086 | 0.32 |
Hs.320151 | AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase. beta) | 0.23 | 0.00086 | 0.43 | 0.00013 | 0.33 |
Hs.77422 | PLP2 | Proteolipid protein 2 (colonic epithelium-enriched) | 0.26 | 0.00043 | 0.42 | 0.00043 | 0.34 |
Hs.1497 | RARG | Retinoic acid receptor. gamma | 0.33 | 0.00043 | 0.35 | 0.00043 | 0.34 |
Hs.389700 | MGST1 | Glutathione S-transferase. microsomal | 0.4 | 0.00022 | 0.29 | 0.00043 | 0.34 |
Hs.292078 | LARP1 | La ribonucleoprotein domain family. member 1 | 0.34 | 0.00043 | 0.36 | 0.00086 | 0.35 |
Hs.334587 | RBPMS | RNA binding protein with multiple splicing | 0.29 | 0.00086 | 0.43 | 0.00022 | 0.36 |
Hs.5298 | ADIPOR1 | Adiponectin receptor 1 | 0.3 | 0.00022 | 0.42 | 0.00013 | 0.36 |
Hs.439894 | CASZ1 | Castor zinc finger 1 | 0.24 | 0.00022 | 0.49 | 0.00086 | 0.37 |
Hs.371727 | SCNN1G | Sodium channel. nonvoltage-gated 1. gamma | 0.29 | 0.00013 | 0.45 | 0.00043 | 0.37 |
Hs.474596 | LIMK2 | LIM domain kinase 2 | 0.26 | 0.00043 | 0.5 | 0.00013 | 0.38 |
Hs.459940 | LITAF | Lipopolysaccharide-induced TNF factor | 0.37 | 0.00022 | 0.39 | 0.00086 | 0.38 |
Hs.442449 | CHST14 | Carbohydrate (N-acetylgalactosamine 4–0) sulfotransferase 14 | 0.42 | 0.00086 | 0.35 | 0.00086 | 0.38 |
Hs.518525 | GLUL | Glutamate-ammonia ligase | 0.42 | 0.00043 | 0.48 | 0.00086 | 0.45 |
Hs.119177 | ARF3 | ADP-ribosylation factor 3 | 0.47 | 0.00013 | 0.45 | 0.00043 | 0.46 |
Hs.497417 | KIAA0317 | KIAA0317 | 0.49 | 0.00086 | 0.44 | 0.00013 | 0.46 |
Hs.501728 | RHOG | Ras homolog gene family. member G (rho G) | 0.46 | 0.00043 | 0.47 | 0.00043 | 0.47 |
Hs.414614 | SCNN1B | Sodium channel. nonvoltage-gated 1. beta | 0.48 | 0.00013 | 0.47 | 0.00022 | 0.47 |
Hs.436896 | POLR3A | Polymerase (RNA) III (DNA directed) polypeptide A. 155 kDa | 0.48 | 0.00043 | 0.47 | 0.00043 | 0.48 |
UniGene ID | Gene symbol | Gene title | A vs. B | p value | A vs. C | p value | Average |
---|---|---|---|---|---|---|---|
Hs.35086 | USP1 | Ubiquitin specific protease 1 (USP1), mRNA. | 42.52 | 0.00022 | 44.32 | 0.00043 | 43.42 |
Hs.436977 | SYTL3 | Synaptotagmin-like 3 | 20.68 | 0.00043 | 26.72 | 0.00013 | 23.70 |
Hs.133421 | LIFR | Leukemia inhibitory factor receptor | 43.71 | 0.00086 | 3.32 | 0.00022 | 23.52 |
Hs.160211 | THRAP3 | Thyroid hormone receptor associated protein 3 (THRAP3), mRNA. | 29.04 | 0.00013 | 3.66 | 0.00043 | 16.35 |
Hs.532399 | ZC3H11A | KIAA0663 gene product (KIAA0663), mRNA. | 4.38 | 0.00043 | 28.05 | 0.00086 | 16.21 |
Hs.652169 | PLGLB2 | Plasminogen-like B2 | 21.71 | 0.00086 | 9.45 | 0.00086 | 15.58 |
Hs.524809 | CLIP1 | Restin (Reed-Steinberg cell-expressed intermediate filament-associated protein) (RSN), transcript variant 2, mRNA. | 2.19 | 0.00043 | 25.81 | 0.00043 | 14.00 |
Hs.16355 | MYH10 | Myosin, heavy polypeptide 10, non-muscle (MYH10), mRNA. | 2.6 | 0.00013 | 24.08 | 0.00022 | 13.34 |
Hs.502829 | SF1 | Splicing factor 1 (SF1), transcript variant 4, mRNA. | 21.86 | 0.00043 | 4.08 | 0.00086 | 12.97 |
Hs.517949 | MAP4 | Microtubule-associated protein 4 (MAP4), transcript variant 1, mRNA. | 10.41 | 0.00043 | 11.96 | 0.00013 | 11.18 |
Hs.8118 | SMCHD1 | KIAA0650 protein | 18.77 | 0.00013 | 2.17 | 0.00043 | 10.47 |
Hs.514806 | GALNT1 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) (GALNT1), mRNA. | 11 | 0.00043 | 9.38 | 0.00043 | 10.19 |
Hs.130293 | LUC7L3 | Cisplatin resistance-associated overexpressed protein (CROP), transcript variant 2, mRNA. | 6.32 | 0.00043 | 11.88 | 0.00022 | 9.10 |
Hs.143728 | WASL | Wiskott-Aldrich syndrome-like (WASL), mRNA. | 2.07 | 0.00022 | 14.32 | 0.00086 | 8.20 |
Hs.532082 | IL6ST | Interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 2, mRNA. | 2.95 | 0.00013 | 13 | 0.00043 | 7.97 |
Hs.2913 | EPHB3 | EphB3 = HEK2 = tyrosine kinase receptor = large erk kinase | 11.39 | 0.00086 | 4.41 | 0.00086 | 7.90 |
Hs.431081 | USP53 | Ubiquitin specific protease 53 | 2.23 | 0.00013 | 13.55 | 0.00043 | 7.89 |
Hs.194726 | BAG4 | BCL2-associated athanogene 4 (BAG4), mRNA. | 11.71 | 0.00013 | 3.16 | 0.00086 | 7.44 |
Hs.464971 | PIK3C3 | Phosphoinositide-3-kinase, class 3 | 3.92 | 0.00043 | 10.41 | 0.00086 | 7.16 |
Hs.9997 | SECISBP2L | KIAA0256 gene product (KIAA0256), mRNA. | 5.43 | 0.00086 | 7.36 | 0.00013 | 6.39 |
Hs.497788 | EPRS | Glutamyl-prolyl-tRNA synthetase (EPRS), mRNA. | 4.41 | 0.00043 | 8.11 | 0.00043 | 6.26 |
Hs.101014 | CEP57 | Translokin (KIAA0092), mRNA. | 5.03 | 0.00086 | 7.31 | 0.00086 | 6.17 |
Hs.143600 | GOLIM4 | Golgi phosphoprotein 4 (GOLPH4), mRNA. | 2.46 | 0.00043 | 9.85 | 0.00022 | 6.16 |
Hs.24485 | SMC3 | Chondroitin sulfate proteoglycan 6 (bamacan) (CSPG6), mRNA. | 2.53 | 0.00022 | 9.65 | 0.00043 | 6.09 |
Hs.193832 | GPATCH4 | G patch domain containing 4 (GPATC4), transcript variant 3, mRNA. | 3.32 | 0.00013 | 7.94 | 0.00086 | 5.63 |
Hs.406695 | PRDM7 | PR domain containing 7 (PRDM7), mRNA. | 2.04 | 0.00086 | 8.46 | 0.00086 | 5.25 |
Hs.42194 | SPCS3 | Signal peptidase complex subunit 3 homolog (S. cerevisiae) (SPCS3), mRNA. | 2.1 | 0.00043 | 8.34 | 0.00022 | 5.22 |
Hs.458418 | KIAA1731 | PREDICTED: KIAA1731 protein (KIAA1731), mRNA. | 2.04 | 0.00013 | 8.4 | 0.00086 | 5.22 |
Hs.49853 | CCAR1 | Cell division cycle and apoptosis regulator 1 | 2.75 | 0.00086 | 7.67 | 0.00013 | 5.21 |
Hs.496414 | ATP7A | ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome) | 2.89 | 0.00086 | 7.16 | 0.00043 | 5.02 |
Hs.481181 | NEK1 | NIMA (never in mitosis gene a)-related kinase 1 (NEK1), mRNA. | 3.07 | 0.00086 | 5.35 | 0.00043 | 4.21 |
Hs.440833 | PKN2 | protein kinase N2 (PKN2), mRNA. | 6.02 | 0.00022 | 2.14 | 0.00043 | 4.08 |
Hs.524009 | AASDHPPT | Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 3.89 | 0.00013 | 4.2 | 0.00086 | 4.04 |
Hs.26904 | SEC63 | SEC63 homolog (S. cerevisiae) | 2.95 | 0.00086 | 3.78 | 0.00043 | 3.37 |
Hs.93485 | SCN2A | MRNA; cDNA DKFZp761D191 (from clone DKFZp761D191) | 2.08 | 0.00043 | 4.5 | 0.00013 | 3.29 |
Hs.31082 | TMEM33 | Transmembrane protein 33 | 2.19 | 0.00086 | 4.35 | 0.00043 | 3.27 |
Hs.371372 | CWC27 | Serologically defined colon cancer antigen 10 (SDCCAG10), mRNA. | 2.95 | 0.00043 | 3.51 | 0.00086 | 3.23 |
Hs.523299 | EIF3A | Eukaryotic translation initiation factor 3, subunit 10 theta, 150/170 kDa (EIF3S10), mRNA. | 2.68 | 0.00022 | 3.58 | 0.00022 | 3.13 |
Hs.440320 | CUL5 | Cullin 5 (CUL5), mRNA. | 2.6 | 0.00043 | 3.25 | 0.00043 | 2.93 |
Hs.203965 | PHTF2 | Putative homeodomain transcription factor 2 | 3.56 | 0.00013 | 2.3 | 0.00086 | 2.93 |
Hs.335068 | TGS1 | Nuclear receptor coactivator 6 interacting protein (NCOA6IP), mRNA. | 3.63 | 0.00086 | 2.16 | 0.00013 | 2.89 |
Hs.189075 | TWF1 | Twinfilin, actin-binding protein, homolog 1 (Drosophila) | 2.36 | 0.00086 | 2.97 | 0.00043 | 2.67 |
Hs.127310 | UHMK1 | U2AF homology motif (UHM) kinase 1 (UHMK1), mRNA. | 2.85 | 0.00086 | 2.46 | 0.00043 | 2.66 |
Hs.430849 | OSBPL8 | Oxysterol binding protein-like 8 (OSBPL8), transcript variant 1, mRNA. | 2.03 | 0.00022 | 3.05 | 0.00022 | 2.54 |
Hs.150557 | KLF9 | Basic transcription element binding protein 1 (BTEB1), mRNA. | 2.6 | 0.00086 | 2.39 | 0.00043 | 2.50 |
Hs.210850 | HECTD1 | HECT domain containing 1 (HECTD1), mRNA. | 2.35 | 0.00013 | 2.6 | 0.00086 | 2.47 |
Hs.142442 | HP1BP3 | Heterochromatin protein 1, binding protein 3 | 2.08 | 0.00086 | 2.41 | 0.00013 | 2.25 |
Hs.369284 | ESF1 | Chromosome 20 open reading frame 6 (C20orf6), mRNA. | 2.13 | 0.00013 | 2.3 | 0.00086 | 2.21 |
Hs.119023 | SMC2 | SMC2 structural maintenance of chromosomes 2-like 1 (yeast) (SMC2L1), mRNA. | 2.25 | 0.00022 | 2 | 0.00022 | 2.13 |
Hs.481927 | NIPBL | Nipped-B homolog (Drosophila) | 2.11 | 0.00043 | 2.04 | 0.00086 | 2.08 |
Hs.374201 | KIF21A | kinesin family member 21A (KIF21A), mRNA. | 2.13 | 0.00013 | 2 | 0.00013 | 2.06 |
Functional associations of transcripts dysregulated in group A vs. control groups
P-regulated genes in women with implantation failure (group A) vs. control (group B)
UniGene ID | Gene symbol | Gene title | Up regulated in window of implantation | Down regulated in endometriosis or mifepristone | Fold change | p value |
---|---|---|---|---|---|---|
Hs.386793 | GPX3 | Glutathione peroxidase 3 (plasma) (GPX3), mRNA. | 0.01 | 0.00013 | ||
Hs.458355 | C1S | Complement component 1, s subcomponent, transcript variant 1, mRNA. | 0.02 | 0.00043 | ||
Hs.647023 | CLDN3 | Claudin 3 | [24] | 0.07 | 0.00086 | |
Hs.89603 | MUC1 | Mucin 1, transmembrane, mRNA. | [25] | [4] | 0.11 | 0.00022 |
Hs.436657 | CLU | Clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J), transcript variant 1, mRNA. | 0.12 | 0.00086 | ||
Hs.276770 | CD52 | CD52 molecule | [7] | 0.14 | 0.00043 | |
Hs.498173 | SMPD1 | Sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase), transcript variant 1, mRNA. | 0.14 | 0.00013 | ||
Hs.523414 | LOC492304 | Putative insulin-like growth factor II associated protein, mRNA. | [27] | 0.15 | 0.00022 | |
Hs.532325
|
PAEP
|
Progestagen-associated endometrial protein
| [39] | 0.15 | 0.00086 | |
Hs.590970 | AXL | AXL receptor tyrosine kinase | [24] | 0.15 | 0.00022 | |
Hs.163893 | PICALM | Phosphatidylinositol binding clathrin assembly protein | [4] | 0.16 | 0.00086 | |
Hs.525607 | TNFAIP2 | Tumor necrosis factor, alpha-induced protein 2, mRNA. | 0.18 | 0.00043 | ||
Hs.654439 | APOE | Apolipoprotein E | 0.18 | 0.00086 | ||
Hs.201978 | PTGS1 | Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), transcript variant 2, mRNA. | [29] | [7] | 0.19 | 0.00013 |
Hs.82071
|
CITED2
|
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, mRNA.
| [25] | 0.19 | 0.00086 | |
Hs.524518 | STAT6 | Signal transducer and activator of transcription 6, interleukin-4 induced, mRNA. | [29] | 0.19 | 0.00022 | |
Hs.478588 | BCL6 | B-cell CLL/lymphoma 6 (zinc finger protein 51), transcript variant 1, mRNA. | 0.20 | 0.00086 | ||
Hs.1012
|
C4BPA
|
Complement component 4 binding protein, alpha
| [39] | 0.22 | 0.00043 | |
Hs.21765 | FADS3 | Fatty acid desaturase 3, mRNA. | [26] | 0.23 | 0.00043 | |
Hs.4055 | KLF6 | Kruppel-like factor 6 | [25] | 0.23 | 0.00013 | |
Hs.332708 | FBLN5 | Fibulin 5, mRNA. | 0.23 | 0.00022 | ||
Hs.25292 | JUNB | Jun B proto-oncogene, mRNA. | 0.25 | 0.00043 | ||
Hs.431048 | ABL1 | V-abl Abelson murine leukemia viral oncogene homolog 1, transcript variant b, mRNA. | [24] | 0.27 | 0.00086 | |
Hs.190783 | HAL | Histidine ammonia-lyase | 0.27 | 0.00086 | ||
Hs.513984 | FLII | Flightless I homolog (Drosophila), mRNA. | 0.27 | 0.00043 | ||
Hs.643357 | ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | [29] | 0.29 | 0.00022 | |
Hs.44227 | HPSE | Heparanase | [29] | 0.29 | 0.00086 | |
Hs.515536 | RRAS | Related RAS viral (r-ras) oncogene homolog, mRNA. | [27] | 0.29 | 0.00013 | |
Hs.409578 | STK38 | Serine/threonine kinase 38 | [26] | 0.29 | 0.00043 | |
Hs.549171 | C1orf56 | Chromosome 1 open reading frame 56 | [7] | 0.29 | 0.00022 | |
Hs.494457 | NINJ1 | Ninjurin 1, mRNA. | [26] | 0.29 | 0.00013 | |
Hs.270291 | ACTN4 | Actinin, alpha 4 (ACTN4), mRNA. | [29] | 0.29 | 0.00086 | |
Hs.381099 | LCP1 | Lymphocyte cytosolic protein 1 (L-plastin), mRNA. | 0.31 | 0.00043 | ||
Hs.185172 | GNB2 | Guanine nucleotide binding protein (G protein), beta polypeptide 2, mRNA. | [26] | 0.31 | 0.00013 | |
Hs.1497
|
RARG
|
Retinoic acid receptor, gamma
| [7] | 0.33 | 0.00043 | |
Hs.474751 | MYH9 | Myosin, heavy polypeptide 9, non-muscle, mRNA. | [29] | 0.33 | 0.00043 | |
Hs.255093 | PFKL | Phosphofructokinase, liver, transcript variant 2, mRNA. | [24] | 0.33 | 0.00086 | |
Hs.503911 | NNMT | Nicotinamide N-methyltransferase | 0.33 | 0.00043 | ||
Hs.504877 | ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta , mRNA. | 0.33 | 0.00022 | ||
Hs.210995 | CA12 | Carbonic anhydrase XII, transcript variant 2, mRNA. | 0.35 | 0.00043 | ||
Hs.520640 | ACTB | Actin, beta, mRNA. | [7] | 0.35 | 0.00086 | |
Hs.514819 | AP2B1 | Adaptor-related protein complex 2, beta 1 subunit, mRNA. | [24] | 0.35 | 0.00013 | |
Hs.511605 | ANXA2 | Annexin A2, transcript variant 2, mRNA. | [29] | 0.35 | 0.00086 | |
Hs.87752 | MSN | Moesin, mRNA. | [29] | 0.35 | 0.00022 | |
Hs.654958 | ABCF2 | ATP-binding cassette, sub-family F (GCN20), member 2 | [7] | 0.35 | 0.00013 | |
Hs.443577 | TNFRSF21 | Tumor necrosis factor receptor superfamily, member 21 | [29] | [4] | 0.35 | 0.00086 |
Hs.591868 | ZBTB10 | Zinc finger and BTB domain containing 10 | [4] | 0.35 | 0.00043 | |
Hs.25348 | VAMP2 | Vesicle-associated membrane protein 2 (synaptobrevin 2) | [4] | 0.38 | 0.00086 | |
Hs.159161 | ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha, mRNA. | [24] | [7] | 0.38 | 0.00022 |
Hs.131269 | RARRES1 | Retinoic acid receptor responder (tazarotene induced) 1 | [27] | 0.38 | 0.00086 | |
Hs.513915 | CLDN7 | Claudin 7, mRNA. | [25] | 0.38 | 0.00013 | |
Hs.10326 | COPE | Coatomer protein complex, subunit epsilon, transcript variant 2, mRNA. | [24] | 0.38 | 0.00013 | |
Hs.416024 | NRSN2 | Neurensin 2 | [7] | 0.38 | 0.00043 | |
Hs.434248 | PLEC | Plectin | [39] | 0.38 | 0.00086 | |
Hs.584854 | AVIL | Advillin | 0.41 | 0.00022 | ||
Hs.183109 | MAOA | Monoamine oxidase A | 0.41 | 0.00013 | ||
Hs.365405 | SELO | Selenoprotein O | [4] | 0.41 | 0.00013 | |
Hs.645228 | KIR3DL1 | Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 | [29] | 0.41 | 0.00086 | |
Hs.528299 | HTATIP | HIV-1 Tat interacting protein, 60 kDa, transcript variant 3, mRNA. | [26] | 0.41 | 0.00043 | |
Hs.164226 | THBS1 | Thrombospondin 1, mRNA. | [29] | 0.41 | 0.00086 | |
Hs.647078 | CDK5 | Cyclin-dependent kinase 5 | [7] | 0.41 | 0.00043 | |
Hs.278573 | CD59 | CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344), transcript variant 2, mRNA. | [29] | 0.41 | 0.00022 | |
Hs.515162 | CALR | Calreticulin | [7] | 0.41 | 0.00043 | |
Hs.465744 | INSR | Insulin receptor | [26] | 0.41 | 0.00013 | |
Hs.274256 | ELOVL7 | ELOVL family member 7, elongation of long chain fatty acids (yeast) | [4] | 0.44 | 0.00086 | |
Hs.450230 | IGFBP3 | Insulin-like growth factor binding protein 3 | 0.44 | 0.00086 | ||
Hs.504687 | MYL9 | Myosin, light polypeptide 9, regulatory | [27] | 0.44 | 0.00022 | |
Hs.446641 | ARAF | V-raf murine sarcoma 3611 viral oncogene homolog, mRNA. | [25] | 0.44 | 0.00086 | |
Hs.2030 | THBD | Thrombomodulin | 0.44 | 0.00013 | ||
Hs.104672 | FILIP1L | Filamin A interacting protein 1-like | [27] | 0.44 | 0.00086 | |
Hs.75862 | SMAD4 | SMAD family member 4 | [4] | 0.44 | 0.00022 | |
Hs.520757 | TBXAS1 | Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A), transcript variant TXS-II, mRNA. | [29] | 0.47 | 0.00013 | |
Hs.283741 | EXOSC5 | Exosome component 5 | [7] | 0.47 | 0.00086 | |
Hs.174312 | TLR4 | Toll-like receptor 4, transcript variant 2, mRNA. | [29] | 0.47 | 0.00043 | |
Hs.24601 | FBLN1 | Fibulin 1 | [31] | [7] | 0.47 | 0.00086 |
Hs.501728
|
RHOG
|
Ras homolog gene family, member G (rho G)
| [7] | 0.47 | 0.00043 | |
Hs.220864 | CHD2 | Chromodomain helicase DNA binding protein 2 | [4] | 0.47 | 0.00086 | |
Hs.524809 | CLIP1 | CAP-GLY domain containing linker protein 1 | [29] | 0.47 | 0.00043 | |
Hs.92236 | MLL4 | Myeloid/lymphoid or mixed-lineage leukemia 4 | [7] | 0.47 | 0.00086 | |
Hs.654688 | MKL1 | Megakaryoblastic leukemia (translocation) 1 | [26] | 0.47 | 0.00043 | |
Hs.279837 | GSTM2 | Glutathione S-transferase mu 2 (muscle) | [26] | 0.47 | 0.00086 | |
Hs.645227 | TGFB1 | Transforming growth factor, beta 1 | [7] | 0.50 | 0.00086 | |
Hs.149261 | RUNX1 | Runt-related transcription factor 1 | [27] | 0.50 | 0.00013 | |
Hs.522818 | L1CAM | L1 cell adhesion molecule (hydrocephalus, stenosis of aqueduct of Sylvius 1, MASA (mental retardation, aphasia, shuffling gait and adducted thumbs) syndrome, spastic paraplegia 1) | [26] | 0.50 | 0.00043 | |
Hs.840 | IDO1 | Indoleamine 2,3-dioxygenase 1 | 0.50 | 0.00086 | ||
Hs.2256 | MMP7 | Matrix metalloproteinase 7 (matrilysin, uterine) | [27] | 0.50 | 0.00043 |
UniGene ID | Gene symbol | Gene title | Down regulated in window of implantation | Up regulated in endometriosis or RU486 | Fold change | p value |
---|---|---|---|---|---|---|
Hs.208854 | CD69 | CD69 antigen (p60, early T-cell activation antigen) | [7] | 2,3 | 0.00022 | |
Hs.406515 | NQO1 | NAD(P)H dehydrogenase, quinone 1 | [29] | 2,2 | 0.00043 | |
Hs.335614 | SEC14L2 | SEC14-like 2 (S. cerevisiae), mRNA. | [4] | 1,9 | 0.00013 | |
Hs.481181
|
NEK1
|
NIMA (never in mitosis gene a)-related kinase 1 (NEK1), mRNA.
| [29] | 1,6 | 0.00043 | |
Hs.86368 | CLGN | Calmegin, mRNA. | [7] | 1,5 | 0.00086 | |
Hs.189075
|
TWF1
|
Twinfilin, actin-binding protein, homolog 1 (Drosophila)
| [4] | 1,5 | 0.00043 | |
Hs.127680 | LOC389332 | PREDICTED: hypothetical LOC389332 (LOC389332), mRNA. | [4] | 1,4 | 0.00013 | |
Hs.369430 | PAM | Peptidylglycine alpha-amidating monooxygenase, transcript variant 3, mRNA. | 1,1 | 0.00022 | ||
Hs.514806
|
GALNT1
|
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1), mRNA.
| [7] | 1,1 | 0.00043 | |
Hs.509447 | GRLF1 | Glucocorticoid receptor DNA binding factor 1 | [7] | 1,1 | 0.00086 | |
Hs.481927
|
NIPBL
|
Nipped-B homolog (Drosophila)
| [7] | 1,1 | 0.00086 | |
Hs.444558 | KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3, mRNA. | [4] | 1,1 | 0.00043 | |
Hs.495710 | GPM6B | Glycoprotein M6B (GPM6B), transcript variant 4, mRNA. | [29] | 1,0 | 0.00022 | |
Hs.496414
|
ATP7A
|
ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)
| [29] | 1,0 | 0.00043 |