Introduction
Materials and methods
Data sources
Statistical analysis
Results
Global burden and trends
Incidence | 1990 | 2019 | 1990–2019 | ||
---|---|---|---|---|---|
Cases NO.(95%UI) | ASR/100,000 (95% CI) | Cases NO.(95%UI) | ASR/100,000 (95% CI) | AAPC% (95%CI) | |
Global | 48554505.95 (45694002.85 to 52168822.4) | 4496.41 (3431.97 to 5966.41) | 52330896.46 (48025168.54 to 57716773.7) | 4003.24 (3139.28 to 5101.4) | -0.4 (-0.51 to -0.3) |
Sex | |||||
Boy | 26416220.36 (24758966.86 to 28460924.74) | 4569.06 (3531.95 to 5969.36) | 28887791.7 (26363871.47 to 32068822.98) | 4145.03 (3254.90 to 5314.40) | -0.36 (-0.46 to -0.25) |
Girl | 22138285.58 (20920822.13 to 23694761.26) | 4419.80 (3322.51 to 5967.01) | 23443104.75 (21666997.69 to 25716158.36) | 3851.90 (3008.93 to 4893.96) | -0.48 (-0.6 to -0.36) |
SDI | |||||
High SDI | 1492630.15 (1279789.94 to 1765155.65) | 1175.76 (892.18 to 1573.99) | 1471405.09 (1223400.11 to 1786140.06) | 1201.98 (891.55 to 1656.19) | 0.06 (-0.07 to 0.18) |
High-middle SDI | 4657097.08 (4231047.21 to 5206690.89) | 1543.97 (1387.34 to 1740.7) | 4744068.72 (4198433.8 to 5437811.82) | 1963.78 (1723.9 to 2269.45) | 0.81 (0.71 to 0.91) |
Middle SDI | 12082296.62 (11166181.41 to 13245258.34) | 2066.15 (1892.13 to 2280.84) | 13681028.33 (12340124.58 to 15413352.65) | 2530.32 (2275.62 to 2849.57) | 0.67 (0.53 to 0.81) |
Low-middle SDI | 20212480.05 (19235958.75 to 21363149.62) | 4283.8 (4040.33 to 4585.04) | 17775411.52 (16379434.83 to 19526408.69) | 3508.87 (3228.13 to 3859.1) | -0.7 (-0.89 to -0.51) |
Low SDI | 10092393.4 (9682574.55 to 10562167.38) | 3813.05 (3615.6 to 4047.5) | 14636987.97 (13841222.94 to 15607947.71) | 3027.57 (2835.82 to 3260.86) | -0.79 (-0.89 to -0.7) |
GBD regions | |||||
Andean Latin America | 99685.48 (94043.87 to 106285.47) | 921.38 (736.56 to 1167.31) | 90176.82 (82878.3 to 99289.97) | 678.36 (559.86 to 831.58) | -1.12 (-1.32 to -0.93) |
Australasia | 44128.96 (40475.76 to 48532.6) | 1049.17 (923.76 to 1207.8) | 49978.41 (45785.07 to 55536.76) | 1010.49 (884.53 to 1184.09) | -0.16 (-0.79 to 0.48) |
Caribbean | 109478.8 (101988.72 to 118915.32) | 2183.07 (1602.06 to 2900.99) | 100393.17 (91919.79 to 111553.14) | 1767.96 (1306.79 to 2360.04) | -0.74 (-0.89 to -0.6) |
Central Asia | 388234.47 (368914.74 to 409993.42) | 2180.17 (1759.53 to 2727.85) | 402101.16 (379080.06 to 429956.12) | 2109.37 (1695.28 to 2690.47) | -0.11 (-0.27 to 0.05) |
Central Europe | 305636.1 (271657.75 to 347183.25) | 1982.61 (1449.9 to 2749.26) | 198164.63 (174732.37 to 229591.41) | 2039.63 (1431.15 to 2940.74) | 0.11 (-0.04 to 0.27) |
Central Latin America | 714708.42 (649350.51 to 797101.62) | 1798.74 (1351.7 to 2401.61) | 724756.32 (639605.28 to 834152.63) | 1524.52 (1206.31 to 1948.87) | -0.61 (-0.66 to -0.56) |
Central Sub-Saharan Africa | 855762.9 (806887.97 to 904989.58) | 5350.14 (4160.88 to 6853.47) | 1433299.05 (1261327.03 to 1,612,817) | 3699.31 (2864.18 to 4684.2) | -1.24 (-1.44 to -1.05) |
East Asia | 3283374.7 (2783790.53 to 3921207.02) | 3239.33 (1953.61 to 5085.77) | 3805845.7 (3152823.25 to 4639794.68) | 2412.99 (1697.93 to 3433.21) | -1.04 (-1.31 to -0.76) |
Eastern Europe | 743956.49 (689018.29 to 811249.52) | 2063.84 (1664.76 to 2656.02) | 562713.96 (513820.92 to 618254.29) | 2329.85 (1781.5 to 3100.32) | 0.39 (0.23 to 0.54) |
Eastern Sub-Saharan Africa | 2351494.22 (2253003.27 to 2464207.12) | 3985.82 (3046.35 to 5265.03) | 3145746.52 (2996586.13 to 3307121.1) | 2808.2 (2232.53 to 3539.49) | -1.21 (-1.28 to -1.14) |
High-income Asia Pacific | 365111.75 (330589.31 to 410697.6) | 1272.74 (1108.46 to 1507.51) | 259914.07 (233539.32 to 294771.26) | 1313.35 (1124.76 to 1579.38) | 0.09 (-0.02 to 0.2) |
High-income North America | 321928.85 (252851.68 to 414653.04) | 642.49 (457.81 to 911.67) | 363860.71 (275816.38 to 474861.6) | 679.15 (469.04 to 982.31) | 0.17 (0.07 to 0.28) |
North Africa and Middle East | 3036488.89 (2874883.31 to 3244454.42) | 3419.89 (2647.53 to 4406.09) | 4279252.11 (3997982.73 to 4639215.69) | 3265.97 (2726.52 to 3981.35) | -0.19 (-0.22 to -0.16) |
Oceania | 61115.19 (58256.35 to 64687.97) | 4073.97 (3056.55 to 5459.99) | 103760.94 (97954.97 to 110151.99) | 3843.95 (2892.36 to 5110.39) | -0.33 (-0.54 to -0.12) |
South Asia | 27226399.43 (25859178.78 to 28955700.22) | 8641.37 (6923.5 to 11042.53) | 25365704.22 (23212695.71 to 28071778.59) | 7861 (6123.81 to 10040.09) | -0.36 (-0.44 to -0.28) |
Southeast Asia | 4576165.48 (4286016.31 to 4942823.94) | 4828.32 (3617.4 to 6448.55) | 4655692.59 (4278864.35 to 5138607.94) | 4106.73 (3260.07 to 5250.54) | -0.56 (-0.77 to -0.35) |
Southern Latin America | 97678.62 (86506.15 to 111589.58) | 951.9 (753.86 to 1206.51) | 125876.14 (110477.42 to 147087.1) | 1015.36 (832.78 to 1249.32) | 0.17 (-0.05 to 0.39) |
Southern Sub-Saharan Africa | 323475.34 (307508.4 to 343125.71) | 2413.53 (1867.41 to 3222.83) | 285974.85 (268249.8 to 307538.79) | 2096.6 (1596.32 to 2771.82) | -0.51 (-0.79 to -0.23) |
Tropical Latin America | 323129.09 (292445.28 to 365516.27) | 1325.53 (927.19 to 1857.95) | 431137.2 (397153.01 to 475140.24) | 1139.58 (951.7 to 1401.66) | -0.57 (-0.68 to -0.45) |
Western Europe | 760860.61 (629062.83 to 930294.09) | 1351.89 (1011.58 to 1841.19) | 741588.33 (604570.53 to 918853.68) | 1358 (1000.31 to 1877.21) | -0.01 (-0.18 to 0.16) |
Western Sub-Saharan Africa | 2565692.18 (2483168.89 to 2666258.76) | 4363.28 (3350.69 to 5720.53) | 5204959.56 (4981654.7 to 5482227.22) | 3595.06 (2958.03 to 4432.47) | -0.69 (-0.83 to -0.54) |
Prevalence | 1990 | 2019 | 1990–2019 | ||
---|---|---|---|---|---|
Cases NO.(95%UI) | ASR/100,000 (95% CI) | Cases NO.(95%UI) | ASR/100,000 (95% CI) | AAPC% (95%CI) | |
Global | 427538173.72 (419116917.08 to 435738379.57) | 24159.03 (23473.13 to 24885.85) | 435071628.35 (425910405.22 to 444749386.4) | 22399.28 (21697.2 to 23100.36) | -0.27 (-0.29 to -0.25) |
Sex | |||||
Boy | 217961120.75 (212461725.02 to 223205808.92) | 23942.69 (22995.96 to 24891.39) | 221385750.05 (214965889.85 to 228027312.86) | 22103.89 (21118.66 to 23133.46) | -0.28 (-0.3 to -0.25) |
Girl | 209577052.97 (204759820.79 to 214397446.43) | 24383.25 (23517.10 to 25260.62) | 213685878.29 (208289369.43 to 218556332.6) | 22713.61 (21883.14 to 23513.60) | -0.24 (-0.26 to -0.23) |
SDI | |||||
High SDI | 13042145.85 (12085614.93 to 14090404.74) | 7670.83 (6737.3 to 8728.86) | 8789314.15 (7912734.22 to 9795651.56) | 5550.85 (4645.77 to 6633.56) | -1.1 (-1.16 to -1.05) |
High-middle SDI | 47055997.46 (45185204.41 to 49017657.37) | 15589.71 (14558.59 to 16654.85) | 27066579.88 (25753819.51 to 28469019.99) | 11185.44 (10286.77 to 12156.93) | -1.15 (-1.17 to -1.12) |
Middle SDI | 121457409.45 (117818360.72 to 125071188.66) | 20840.04 (19874.23 to 21876.56) | 87610999.31 (84568163.1 to 90736517.23) | 16070.83 (15202.45 to 16936.67) | -0.89 (-0.94 to -0.85) |
Low-middle SDI | 152715843.43 (148369382.95 to 156558693.48) | 33169.77 (31848.03 to 34461.13) | 145281665.75 (141116715.93 to 149724155.62) | 28182.19 (26936.41 to 29523.89) | -0.57 (-0.59 to -0.54) |
Low SDI | 93040316.68 (91055637.67 to 95034794.93) | 37338.54 (36055.12 to 38664.53) | 166067518.41 (162306392.91 to 169819823.89) | 34848.07 (33519.15 to 36205.93) | -0.24 (-0.24 to -0.23) |
GBD regions | |||||
Andean Latin America | 3312670.77 (3003432.97 to 3677350.58) | 21887.6 (18193.14 to 25849.17) | 2731712.77 (2375935.18 to 3104033.69) | 15083.03 (12055.98 to 18680.62) | -1.29 (-1.34 to -1.23) |
Australasia | 452010.93 (339838.22 to 593351.52) | 10099.66 (6525.96 to 15181.6) | 406253.6 (289655.41 to 559396.99) | 7661.7 (4707.83 to 12248.94) | -0.95 (-0.98 to -0.92) |
Caribbean | 2475705.58 (2295155.38 to 2650613.84) | 21513.17 (18975.85 to 24292.81) | 2525074.79 (2318653.37 to 2730995.9) | 21816.73 (18998.58 to 24894.72) | 0.06 (0.03 to 0.08) |
Central Asia | 6169059.32 (5803801.02 to 6525179.61) | 24080.92 (21649.95 to 26640.02) | 5505676.85 (5027648.01 to 5995790.7) | 20250.6 (17308.75 to 23364.37) | -0.61 (-0.65 to -0.57) |
Central Europe | 4206401.09 (3836976.36 to 4582803.74) | 15230.06 (13083.18 to 17499.8) | 1913944.3 (1711022.05 to 2139635.41) | 11267.46 (9384.59 to 13584.93) | -1.03 (-1.05 to -1.01) |
Central Latin America | 9192531.4 (8737600.67 to 9705081.58) | 14241.45 (13113.09 to 15499.98) | 6798067.69 (6364501.33 to 7226248.32) | 10648.93 (9663.8 to 11729.26) | -1 (-1.02 to -0.98) |
Central Sub-Saharan Africa | 9305417.1 (8745324.71 to 9896496.68) | 35265.71 (31503.99 to 38994.46) | 19046346.76 (17572990.17 to 20611885.64) | 33158.26 (29238.85 to 37291.97) | -0.21 (-0.27 to -0.15) |
East Asia | 43540380.72 (40621807.58 to 46575743.93) | 12913.96 (11428.86 to 14486.66) | 13264058.79 (11894525.65 to 15066393.1) | 5632.23 (4663.83 to 6775.98) | -2.84 (-2.92 to -2.76) |
Eastern Europe | 4509274.44 (3961114.03 to 5123504.97) | 8927.23 (7156.05 to 11153.17) | 2483223.82 (2039694.15 to 3036993.13) | 6850.83 (5106.01 to 9385.69) | -0.91 (-0.99 to -0.83) |
Eastern Sub-Saharan Africa | 30253957.42 (29477970.54 to 31085275.03) | 32464.23 (31092.14 to 33893.09) | 51751685.27 (50066321.52 to 53494965.4) | 29013.16 (27463.51 to 30604.96) | -0.39 (-0.42 to -0.36) |
High-income Asia Pacific | 3688925.79 (3,081,159 to 4389485.49) | 11032.35 (8100.85 to 14970.07) | 1644464.5 (1285276.69 to 2082617.9) | 7334.47 (4948.03 to 10826.92) | -1.4 (-1.43 to -1.36) |
High-income North America | 2,736,783 (2267189.81 to 3221669.99) | 4455.18 (3244.22 to 5986.88) | 2691906.17 (2,043,973 to 3464132.74) | 4157.25 (2605.55 to 6311.11) | -0.26 (-0.34 to -0.19) |
North Africa and Middle East | 31667374.35 (30215764.7 to 33258190.43) | 21542.74 (19708.3 to 23486.42) | 30702567.64 (28911681.61 to 32699538.38) | 17634.29 (15983.34 to 19424.52) | -0.69 (-0.71 to -0.67) |
Oceania | 680578.81 (624417.44 to 741498.16) | 25300.34 (21775.23 to 28882.38) | 1234865.73 (1108438.77 to 1358192.71) | 24721.99 (20513.38 to 29253.53) | -0.08 (-0.11 to -0.06) |
South Asia | 177,686,205 (172762062.31 to 182129724.18) | 39965.29 (38404.75 to 41574.59) | 175315418.13 (170141183.26 to 180859582.95) | 34629.26 (33011.33 to 36310.4) | -0.5 (-0.52 to -0.47) |
Southeast Asia | 43043216.66 (40735023.76 to 45556462.97) | 25055.83 (22846.62 to 27417.94) | 26625176.44 (24842233.91 to 28508595.91) | 16291.32 (14658.9 to 18151.54) | -1.49 (-1.53 to -1.45) |
Southern Latin America | 2254598.19 (1972286.5 to 2587027.56) | 15178.24 (12036.75 to 18935.13) | 1561766.45 (1245267.64 to 1911273.3) | 10855.03 (7442.84 to 15077.54) | -1.15 (-1.23 to -1.07) |
Southern Sub-Saharan Africa | 4136325.36 (3748563.36 to 4565291.13) | 20248.41 (16735.05 to 23829.14) | 4094501.1 (3681025.99 to 4562848.23) | 17396.17 (14641.99 to 20733.09) | -0.52 (-0.56 to -0.48) |
Tropical Latin America | 9640746.91 (8209698.15 to 11298816.22) | 18136.87 (13616.33 to 23446.72) | 6601914.66 (5410937.76 to 7955812.18) | 13608.71 (9654.23 to 18315.45) | -0.98 (-1 to -0.97) |
Western Europe | 5228875.2 (4680301.63 to 5844334.19) | 7596.76 (6318.05 to 9057.72) | 3530913.66 (3057241.26 to 4044236.9) | 5302.55 (4252.03 to 6580.18) | -1.23 (-1.3 to -1.17) |
Western Sub-Saharan Africa | 33357135.68 (32290817.76 to 34497517.85) | 36670.37 (34596.88 to 38709.21) | 74642089.22 (70967310.47 to 78347904.17) | 37218.83 (34341.32 to 39968.12) | 0.05 (0.04 to 0.07) |
DALY | 1990 | 2019 | 1990–2019 | ||
---|---|---|---|---|---|
Cases NO.(95%UI) | ASR/100,000 (95% CI) | Cases NO.(95%UI) | ASR/100,000 (95% CI) | AAPC% (95%CI) | |
Global | 67004080.08 (52751020.67 to 86643263.5) | 3729.04 (2847.3 to 4908.53) | 26339578.19 (20235568.07 to 33595122.77) | 1363.88 (1031.97 to 1776.16) | -3.41 (-3.63 to -3.19) |
Sex | |||||
Boy | 33419025.1 (26637974.67 to 40916879.04) | 3614.15 (2807.38 to 4503.39) | 13025360.94 (9864886.46 to 16811589.29) | 1306.97 (979.63 to 1716.97) | -3.46 (-3.68 to -3.24) |
Girl | 33585054.99 (24142068.49 to 46837276.24) | 3850.55 (2715.66 to 5429.04) | 13314217.25 (10110307.49 to 17084398.46) | 1424.63 (1063.49 to 1873) | -3.3 (-3.47 to -3.12) |
SDI | |||||
High SDI | 341980.75 (228033.75 to 487956.62) | 199.81 (131.57 to 289.29) | 197857.84 (127021.31 to 290459.55) | 122.5 (76.06 to 184.44) | -1.68 (-1.76 to -1.59) |
High-middle SDI | 2708169.98 (2133675.99 to 3410532.86) | 899.32 (690.97 to 1153.36) | 889866.58 (609368.87 to 1255173.37) | 366.94 (250.58 to 521.57) | -3.05 (-3.15 to -2.95) |
Middle SDI | 10466118.15 (8593891.46 to 12843715.96) | 1789.5 (1452.42 to 2245.48) | 3672925.78 (2653216.48 to 4948693.12) | 674.83 (488.86 to 914.71) | -3.34 (-3.43 to -3.26) |
Low-middle SDI | 30738507.97 (22278511.41 to 41320066.1) | 6470.76 (4546.44 to 8835.53) | 8014898.63 (6,051,123 to 10526655.07) | 1567.18 (1163.53 to 2060.43) | -4.76 (-5.27 to -4.25) |
Low SDI | 22718618.86 (18012183.07 to 29698464.9) | 8440.29 (6539.33 to 11248.41) | 13549000.3 (10635432.97 to 16958567.26) | 2812 (2115.95 to 3657.25) | -3.73 (-3.9 to -3.57) |
GBD regions | |||||
Andean Latin America | 511677.4 (423122.87 to 621655.31) | 3309.88 (2628.55 to 4216.81) | 120317.29 (86916.85 to 161469.57) | 664.05 (449.27 to 940.4) | -5.46 (-5.56 to -5.37) |
Australasia | 8860.13 (5057.58 to 15407.74) | 197.11 (95.42 to 389.69) | 6995.77 (3819.4 to 12018.66) | 130.77 (60.24 to 261.22) | -1.4 (-1.45 to -1.35) |
Caribbean | 412817.06 (317256.35 to 543963.11) | 3510.89 (2605.76 to 4785.57) | 162804.51 (120079.26 to 218291.64) | 1417.43 (974.11 to 2029.73) | -3.08 (-3.24 to -2.91) |
Central Asia | 267502.23 (189977.96 to 369112.66) | 1039.6 (722.49 to 1477.17) | 184141.18 (121262.74 to 261707.83) | 677.64 (422.75 to 1014.64) | -1.47 (-1.52 to -1.43) |
Central Europe | 130528.41 (85912.89 to 189186.58) | 467.79 (295.82 to 699.94) | 48429.49 (30899.46 to 71826.82) | 281.55 (172.93 to 432.63) | -1.73 (-1.78 to -1.69) |
Central Latin America | 1147864.39 (1001992.5 to 1310773.37) | 1762.32 (1503.8 to 2043.65) | 323253.84 (251195.63 to 410457.11) | 509.14 (385.13 to 663.03) | -4.19 (-4.37 to -4.01) |
Central Sub-Saharan Africa | 2441366.7 (1699192.53 to 3479392.65) | 8156.01 (5499.16 to 11932.09) | 1243314.72 (907797.06 to 1663642.13) | 2133.92 (1475.85 to 2978.16) | -4.51 (-4.6 to -4.43) |
East Asia | 4106152.11 (3411183.28 to 4907729.31) | 1204.44 (950.97 to 1490.85) | 371575.37 (262424.15 to 512108.85) | 158.33 (105.3 to 231.15) | -6.9 (-8.72 to -5.03) |
Eastern Europe | 122277.87 (83798.06 to 172575.93) | 240.47 (155.29 to 365.12) | 56215.84 (36374.57 to 84279.58) | 153.2 (90.4 to 251.25) | -1.55 (-1.65 to -1.46) |
Eastern Sub-Saharan Africa | 10488649.6 (8273360.92 to 13458073.08) | 10389.59 (8053.71 to 13526.02) | 4887294.47 (3861116.92 to 6101895.69) | 2700.64 (2064.35 to 3504.95) | -4.51 (-5.01 to -4.01) |
High-income Asia Pacific | 101581.9 (62240.92 to 153980.06) | 295.91 (169.18 to 485.51) | 36424.67 (21680.33 to 58544.85) | 158.86 (81.84 to 282.03) | -2.12 (-2.18 to -2.06) |
High-income North America | 58239.77 (36593.66 to 87533.15) | 94.91 (55.13 to 151.95) | 58525.87 (34886.61 to 92182.79) | 88.13 (44.76 to 156.32) | -0.28 (-0.38 to -0.17) |
North Africa and Middle East | 2346154.01 (1692013.85 to 3634202.9) | 1568.58 (1102.02 to 2501.05) | 1244436.21 (895835.72 to 1725576.38) | 716 (500.53 to 1003.64) | -2.65 (-2.76 to -2.54) |
Oceania | 42881.7 (32434.11 to 55839.05) | 1574.59 (1136.52 to 2144.04) | 59387.74 (41574.98 to 80694.99) | 1181.19 (779.16 to 1706.55) | -0.98 (-1.25 to -0.72) |
South Asia | 32935873.86 (23396975.49 to 44554668.52) | 7201.79 (4939.54 to 9871.73) | 9600280.24 (6996736.8 to 12771201.26) | 1915.32 (1378.42 to 2585.07) | -4.45 (-4.51 to -4.38) |
Southeast Asia | 3748702.19 (2855091.79 to 5015088.52) | 2188.48 (1565.36 to 3032.9) | 1053103.84 (768035.42 to 1424535.44) | 645.76 (460.81 to 881.21) | -4.14 (-4.22 to -4.05) |
Southern Latin America | 129707.04 (103855.83 to 165808.31) | 874.69 (672.31 to 1165.11) | 41516.83 (27137.93 to 63328.17) | 287.74 (168.64 to 491.18) | -3.81 (-4.22 to -3.41) |
Southern Sub-Saharan Africa | 721075.85 (571850.37 to 904773.37) | 3512.03 (2682.44 to 4557.02) | 426811.77 (323456.21 to 545320.47) | 1827.65 (1323.21 to 2472.44) | -2.17 (-2.69 to -1.66) |
Tropical Latin America | 1397103.69 (1187212.59 to 1642584.9) | 2730.03 (2245.58 to 3345.42) | 300058.31 (218826.79 to 412879.09) | 623.55 (414.92 to 919.1) | -4.97 (-5.11 to -4.83) |
Western Europe | 122908.29 (79155.03 to 176072.06) | 175.42 (108.33 to 260.66) | 81039.61 (52000.87 to 117469.84) | 118.45 (72.4 to 181.86) | -1.36 (-1.44 to -1.27) |
Western Sub-Saharan Africa | 5762155.88 (4540596.2 to 7223029.13) | 5849.09 (4461.75 to 7575.25) | 6033650.61 (4635254.4 to 7718440.27) | 2961.72 (2177.06 to 3944.28) | -2.32 (-2.49 to -2.15) |