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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

01.02.2016 | Original Article

Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014

verfasst von: L. Huang, X. Luo, J. Shao, H. Yan, Y. Qiu, P. Ke, W. Zheng, B. Xu, W. Li, D. Sun, D. Cao, C. Chen, F. Zhuo, X. Lin, F. Tang, B. Bao, Y. Zhou, X. Zhang, H. Li, J. Li, D. Wan, L. Yang, Y. Chen, Q. Zhong, X. Gu, J. Liu, L. Huang, R. Xie, X. Li, Y. Xu, Z. Luo, M. Liao, H. Wang, L. Sun, H. Li, G. W. Lau, C. Duan

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 2/2016

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Abstract

Dengue is a rapidly spreading mosquito-borne disease caused by the dengue virus (DENV) and has emerged as a severe public health problem around the world. Guangdong, one of the southern Chinese provinces, experienced a serious outbreak of dengue in 2014, which was believed to be the worst dengue epidemic in China over the last 20 years. To better understand the epidemic, we collected the epidemiological data of the outbreak and analyzed 14,594 clinically suspected dengue patients from 25 hospitals in Guangdong. Dengue cases were then laboratory-confirmed by the detection of DENV non-structural protein 1 (NS1) antigen and/or DENV RNA. Afterwards, clinical manifestations of dengue patients were analyzed and 93 laboratory-positive serum specimens were chosen for the DENV serotyping and molecular analysis. Our data showed that the 2014 dengue outbreak in Guangdong had spread to 20 cities and more than 45 thousand people suffered from dengue fever. Of 14,594 participants, 11,387 were definitively diagnosed. Most manifested with a typical non-severe clinical course, and 1.96 % developed to severe dengue. The strains isolated successfully from the serum samples were identified as DENV-1. Genetic analyses revealed that the strains were classified into genotypes I and V of DENV-1, and the dengue epidemic of Guangdong in 2014 was caused by indigenous cases and imported cases from the neighboring Southeast Asian countries of Malaysia and Singapore. Overall, our study is informative and significant to the 2014 dengue outbreak in Guangdong and will provide crucial implications for dengue prevention and control in China and elsewhere.

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Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL et al (2013) The global distribution and burden of dengue. Nature 496:504–507. doi:10.1038/nature12060 PubMedCentralCrossRefPubMed

Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ et al (2010) Dengue: a continuing global threat. Nat Rev Microbiol 8:S7–S16. doi:10.1038/nrmicro2460 PubMedCentralCrossRefPubMed

Whitehead SS, Blaney JE, Durbin AP, Murphy BR (2007) Prospects for a dengue virus vaccine. Nat Rev Microbiol 5:518–528. doi:10.1038/nrmicro1690 CrossRefPubMed

Arima Y, Edelstein ZR, Han HK, Matsui T (2013) Epidemiologic update on the dengue situation in the Western Pacific Region, 2011. Western Pac Surveill Response J 4:47–54. doi:10.5365/WPSAR.2012.3.4.019 PubMedCentralPubMed

Mackey TK, Liang BA (2012) Threats from emerging and re-emerging neglected tropical diseases (NTDs). Infect Ecol Epidemiol 2:75–88. doi:10.3402/iee.v2i0.18667

de Alwis R, Williams KL, Schmid MA, Lai C-Y, Patel B, Smith SA et al (2014) Dengue viruses are enhanced by distinct populations of serotype cross-reactive antibodies in human immune sera. PLoS Pathog 10:e1004386. doi:10.1371/journal.ppat.1004386 PubMedCentralCrossRefPubMed

Holmes EC, Twiddy SS (2003) The origin, emergence and evolutionary genetics of dengue virus. Infect Genet Evol 3:19–28. doi:10.1016/S1567-1348(03)00004-2 CrossRefPubMed

Normile D (2013) Tropical medicine. Surprising new dengue virus throws a spanner in disease control efforts. Science 342:415. doi:10.1126/science.342.6157.415 CrossRefPubMed

World Health Organization (WHO) (2009) Dengue: guidelines for diagnosis, treatment, prevention and control—new edition. 2009. WHO, Geneva

10.

Senaratne TN, Noordeen F (2014) Diagnosis of dengue in Sri Lanka: improvements to the existing state of the art in the island. Trans R Soc Trop Med Hyg 108:685–691. doi:10.1093/trstmh/tru131 CrossRefPubMed

11.

Martina BEE, Koraka P, Osterhaus ADME (2009) Dengue virus pathogenesis: an integrated view. Clin Microbiol Rev 22:564–581. doi:10.1128/CMR.00035-09 PubMedCentralCrossRefPubMed

12.

Pagliari C, Quaresma JAS, Fernandes ER, Stegun FW, Brasil RA, de Andrade HF et al (2014) Immunopathogenesis of dengue hemorrhagic fever: contribution to the study of human liver lesions. J Med Virol 86:1193–1197. doi:10.1002/jmv.23758 CrossRefPubMed

13.

Shepard DS, Undurraga EA, Halasa YA (2013) Economic and disease burden of dengue in Southeast Asia. PLoS Negl Trop Dis 7:e2055. doi:10.1371/journal.pntd.0002055 PubMedCentralCrossRefPubMed

14.

Young JW, Gibbons RV, Rothman AL, Tannitisupawong D, Srikiatkhachorn A, Jarman RG et al (2014) Dengue severity and blood group. Dengue Bulletin (in press)

15.

Undurraga EA, Betancourt-Cravioto M, Ramos-Castañeda J, Martínez-Vega R, Méndez-Galván J, Gubler DJ et al (2015) Economic and disease burden of dengue in Mexico. PLoS Negl Trop Dis 9:e0003547. doi:10.1371/journal.pntd.0003547 PubMedCentralCrossRefPubMed

16.

Ninphanomchai S, Chansang C, Hii YL, Rocklöv J, Kittayapong P (2014) Predictiveness of disease risk in a global outreach tourist setting in Thailand using meteorological data and vector-borne disease incidences. Int J Environ Res Public Health 11:10694–10709. doi:10.3390/ijerph111010694 PubMedCentralCrossRefPubMed

17.

Murray NEA, Quam MB, Wilder-Smith A (2013) Epidemiology of dengue: past, present and future prospects. Clin Epidemiol 5:299–309. doi:10.2147/CLEP.S34440 PubMedCentralPubMed

18.

Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S (2011) MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28:2731–2739. doi:10.1093/molbev/msr121 PubMedCentralCrossRefPubMed

19.

Barclay E (2008) Is climate change affecting dengue in the Americas? Lancet 371:973–974CrossRefPubMed

20.

Russell RC, Currie BJ, Lindsay MD, Mackenzie JS, Ritchie SA, Whelan PI (2009) Dengue and climate change in Australia: predictions for the future should incorporate knowledge from the past. Med J Aust 190:265–268PubMed

21.

Colón-González FJ, Fezzi C, Lake IR, Hunter PR (2013) The effects of weather and climate change on dengue. PLoS Negl Trop Dis 7:e2503. doi:10.1371/journal.pntd.0002503 PubMedCentralCrossRefPubMed

22.

Xiong Y, Chen Q (2014) Epidemiology of dengue fever in China since 1978. Nan Fang Yi Ke Da Xue Xue Bao 34:1822–1825PubMed

23.

Wu W, Bai Z, Zhou H, Tu Z, Fang M, Tang B et al (2011) Molecular epidemiology of dengue viruses in southern China from 1978 to 2006. Virol J 8:322. doi:10.1186/1743-422X-8-322 PubMedCentralCrossRefPubMed

24.

Wu Y, Zheng X, Wu Z (2014) Dengue fever in China. In: Treatment of human parasitosis in traditional Chinese medicine. Springer Berlin Heidelberg, Berlin, pp 239–253. doi:10.1007/978-3-642-39824-7_15 CrossRef

25.

Guo R-N, Lin J-Y, Li L-H, Ke C-W, He J-F, Zhong H-J et al (2014) The prevalence and endemic nature of dengue infections in Guangdong, South China: an epidemiological, serological, and etiological study from 2005–2011. PLoS One 9:e85596. doi:10.1371/journal.pone.0085596 PubMedCentralCrossRefPubMed

26.

Luo L, Liang HY, Hu YS, Liu WJ, Wang YL, Jing QL et al (2012) Epidemiological, virological, and entomological characteristics of dengue from 1978 to 2009 in Guangzhou, China. J Vector Ecol 37:230–240. doi:10.1111/j.1948-7134.2012.00221.x CrossRefPubMed

27.

Liang H, Luo L, Yang Z, Di B, Bai Z, He P et al (2013) Re-emergence of dengue virus type 3 in canton, China, 2009–2010, associated with multiple introductions through different geographical routes. PLoS One 8:e55353. doi:10.1371/journal.pone.0055353 PubMedCentralCrossRefPubMed

28.

Ocazionez RE, Cortés FM, Villar LA, Gómez SY (2006) Temporal distribution of dengue virus serotypes in Colombian endemic area and dengue incidence. Re-introduction of dengue-3 associated to mild febrile illness and primary infection. Mem Inst Oswaldo Cruz 101:725–731. doi:10.1590/S0074-02762006000700004 CrossRefPubMed

29.

Xu G, Dong H, Shi N, Liu S, Zhou A, Cheng Z et al (2007) An outbreak of dengue virus serotype 1 infection in Cixi, Ningbo, People’s Republic of China, 2004, associated with a traveler from Thailand and high density of Aedes albopictus. Am J Trop Med Hyg 76:1182–1188PubMed

30.

Wu J-Y, Lun Z-R, James AA, Chen X-G (2010) Dengue fever in mainland China. Am J Trop Med Hyg 83:664–671. doi:10.4269/ajtmh.2010.09-0755 PubMedCentralCrossRefPubMed

31.

Rothman AL (2004) Dengue: defining protective versus pathologic immunity. J Clin Invest 113:946–951. doi:10.1172/JCI21512 PubMedCentralCrossRefPubMed

32.

Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S et al (2000) Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis 181:2–9. doi:10.1086/315215 CrossRefPubMed

33.

Kliks SC, Nimmanitya S, Nisalak A, Burke DS (1988) Evidence that maternal dengue antibodies are important in the development of dengue hemorrhagic fever in infants. Am J Trop Med Hyg 38:411–419PubMed

34.

Simmons CP, Chau TNB, Thuy TT, Tuan NM, Hoang DM, Thien NT et al (2007) Maternal antibody and viral factors in the pathogenesis of dengue virus in infants. J Infect Dis 196:416–424. doi:10.1086/519170 PubMedCentralCrossRefPubMed

35.

Wang Y, Si L, Luo Y, Guo X, Zhou J, Fang D et al (2015) Replacement of pr gene with Japanese encephalitis virus pr using reverse genetics reduces antibody-dependent enhancement of dengue virus 2 infection. Appl Microbiol Biotechnol 22:9685–9698. doi:10.1007/s00253-015-6819-3 CrossRef

36.

Wang B, Li Y, Feng Y, Zhou H, Liang Y, Dai J et al (2015) Phylogenetic analysis of dengue virus reveals the high relatedness between imported and local strains during the 2013 dengue outbreak in Yunnan, China: a retrospective analysis. BMC Infect Dis 15:142. doi:10.1186/s12879-015-0908-x PubMedCentralCrossRefPubMed

37.

He J-F, Luo H-M, Liang W-J, Zheng K, Kang M, Liu L-P (2007) Epidemic situation of dengue fever in Guangdong province, China, 1990–2005. WHO Regional Office for South-East Asia, New Delhi

38.

Sun J, Wu D, Zhou H, Zhang H, Guan D, He X et al (2015) The epidemiological characteristics and genetic diversity of dengue virus during the third largest historical outbreak of dengue in Guangdong, China, in 2014. J Infect. doi:10.1016/j.jinf.2015.10.007

Titel: Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014
verfasst von: L. Huang
X. Luo
J. Shao
H. Yan
Y. Qiu
P. Ke
W. Zheng
B. Xu
W. Li
D. Sun
D. Cao
C. Chen
F. Zhuo
X. Lin
F. Tang
B. Bao
Y. Zhou
X. Zhang
H. Li
J. Li
D. Wan
L. Yang
Y. Chen
Q. Zhong
X. Gu
J. Liu
L. Huang
R. Xie
X. Li
Y. Xu
Z. Luo
M. Liao
H. Wang
L. Sun
H. Li
G. W. Lau
C. Duan
Publikationsdatum: 01.02.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 2/2016
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-015-2540-5

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