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14.04.2022 | Original Article

Epidemiology and outcomes of pneumococcal sepsis in children with nephrotic syndrome in a developing country

verfasst von: Georgie Mathew, Anish Sam George, R. V. Deepthi, Winsley Rose, Valsan Philip Verghese, Rosemol Varghese, Balaji Veeraraghavan, Indira Agarwal

Erschienen in: Pediatric Nephrology | Ausgabe 1/2023

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Abstract

Background

Pneumococcal infections are common in children with nephrotic syndrome. Knowledge of the commonly available serotypes and antibiotic susceptibility will help in prevention and appropriate management of pneumococcal sepsis, especially in resource-limited countries.

Methods

Demographic, clinical, and laboratory data on children with nephrotic syndrome and pneumococcal infections were extracted from the electronic medical records.

Results

Sixty-three isolates of pneumococci obtained from 60 children with nephrotic syndrome, over a period of 14 years, were included in the study. This represented 18% of all pneumococcal infections occurring in children during the same period. Commonly available vaccines covered up to 58% of all the serotypes causing infection. Severe disease, with shock, intensive care admission and/or meningitis, was observed in 38% children and mortality was observed in 10%. Resistance to commonly used antibiotics was not observed, except for erythromycin.

Conclusions

Pneumococcal sepsis was observed to be common in children with nephrotic syndrome and results in significant morbidity and mortality. Commonly used antibiotics were observed to be effective in management of the infections.

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Titel: Epidemiology and outcomes of pneumococcal sepsis in children with nephrotic syndrome in a developing country
verfasst von: Georgie Mathew
Anish Sam George
R. V. Deepthi
Winsley Rose
Valsan Philip Verghese
Rosemol Varghese
Balaji Veeraraghavan
Indira Agarwal
Publikationsdatum: 14.04.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 1/2023
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-022-05550-0

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Epidemiology and outcomes of pneumococcal sepsis in children with nephrotic syndrome in a developing country

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