Erratum
After publication of the original article [1], it came to the authors’ attention that there were data entry errors in the following variables: age, sex, education, MOCA, WML volume, and ADAS-Cog. Changes have been made to Tables 1, 2, 3 and 4, to reflect the updated results, which are published in their correct version here. However, the authors note that the study conclusions have not changed.
Table 1
Descriptive characteristic
Variable | Mean | SD |
|---|---|---|
Age | 71.73 | 7.91 |
Female Sex, No. (%) | 7 | 32 |
Education, No. (%) | ||
High school education | 6 | 27 |
Trade or professional certificate or diploma | 2 | 9 |
University education | 14 | 64 |
MMSE (max. score 30) | 27.50 | 1.95 |
MOCA (max. score 30) | 23.32 | 2.08 |
WHR | 0.91 | 0.08 |
BMI | 26.95 | 4.78 |
PIB-positive, No. (%) | 6 | 27.27 |
Global PIB BPND
| 0.07 | 0.23 |
WML volume (mm3), n = 16 | 2004.40 | 2761.15 |
Cognitive Assessments | ||
ADAS-Cog (max. score 70) | 9.63 | 3.88 |
Exit-25 (max. score 50) | 10.59 | 4.38 |
Stroop CW-C, sec. | 61.44 | 26.01 |
Trails B-A, sec. | 50.51 | 24.84 |
Digits F-B, sec. | 3.23 | 2.79 |
Table 2
Correlation matrix
PIB BPND
| Age | Education | APOE ε4 | ADAS-Cog | MOCA | EXIT 25 | Digits | Stroop | Trails | |
|---|---|---|---|---|---|---|---|---|---|---|
PIB BPND
| ||||||||||
Age | -0.00 | |||||||||
Education | -0.23 | -0.39 | ||||||||
APOE ε4 | 0.36 | 0.09 | -0.20 | |||||||
ADAS-Cog | 0.53* | 0.16 | -0.11 | 0.53* | ||||||
MOCA | -0.54* | -0.20 | 0.06 | -0.11 | -0.45* | |||||
EXIT-25 | 0.13 | 0.20 | -0.20 | 0.25 | 0.49* | -0.52* | ||||
Digits | 0.02 | 0.17 | -0.35 | -0.45* | -0.30 | 0.13 | -0.04 | |||
Stroop | 0.17 | -0.06 | 0.02 | -0.11 | 0.27 | -0.29 | 0.34 | 0.04 | ||
Trails | 0.19 | -0.08 | -0.25 | 0.48* | 0.15 | -0.18 | 0.29 | 0.01 | 0.13 |
Table 3
Multiple linear regression models assessing the contribution of PIB retention on ADAS-Cog
Independent variables | R2
| Adjusted R2
| R2 Change | Unstandardized B (Standard Error) | Standardized β |
P- Value |
|---|---|---|---|---|---|---|
Model 1 | ||||||
PIB BPND
| 0.28 | 0.24 | - | 9.09 (3.29) | 0.53 | 0.01 |
Model 2 | ||||||
Step 1 | 0.30 | 0.18 | 0.30 | |||
Age | 0.07 (0.11) | 0.14 | 0.54 | |||
Education | 0.41 (1.86) | 0.05 | 0.83 | |||
APOE ε4 | 4.30 (1.64) | 0.53 | 0.02 | |||
Step 2 | 0.44 | 0.31 | 0.15* | |||
Age | 0.09 (0.10) | 0.18 | 0.37 | |||
Education | 1.15 (1.74) | 0.14 | 0.52 | |||
APOE ε4 | 3.20 (1.59) | 0.39 | 0.06 | |||
PIB BPND
| 7.23 (3.42) | 0.42 | 0.05 | |||
Table 4
Multiple linear regression models assessing the contribution of PIB retention on MOCA
Independent variables | R2
| Adjusted R2
| R2 Change | Unstandardized B (Standard Error) | Standardized β |
P- Value |
|---|---|---|---|---|---|---|
Model 1 | ||||||
PIB BPND
| 0.29 | 0.26 | - | -5.00 (1.74) | -0.54 | 0.01 |
Model 2 | ||||||
Step 1 | 0.05 | -0.11 | 0.05 | |||
Age | -0.06 (0.07) | -0.21 | 0.41 | |||
Education | -0.22 (1.16) | -0.05 | 0.85 | |||
APOE ε4 | -0.43 (1.02) | -0.10 | 0.68 | |||
Step 2 | 0.37 | 0.22 | 0.32* | |||
Age | -0.07 (0.06) | -0.28 | 0.20 | |||
Education | -0.80 (0.99) | -0.18 | 0.43 | |||
APOE ε4 | 0.44 (0.91) | 0.10 | 0.63 | |||
PIB BPND
| -5.71 (1.95) | -0.62 | 0.01 | |||
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