Anzeige
Erschienen in:
01.05.2003
Evaluation of scar formation after botulinum toxin injection or Forced balloon dilation to the lower esophageal sphincter
Erschienen in: Surgical Endoscopy | Ausgabe 5/2003
Einloggen, um Zugang zu erhaltenAbstract
Background: It has been postulated that nonsurgical treatments for achalasia cause fibrosis, increasing the risk of surgical Heller myotomy. The goal of this study was to evaluate fibrosis, muscle fracture, and esophageal inflammation after these treatments. Methods: Eighteen female swine were divided into three groups: 6 were euthanized and their lower esophageal sphincters were harvested (group 1); 6 underwent botulinum toxin injection (group 2); and 6 underwent forced balloon dilatation (group 3). Groups 2 and 3 were euthanized 30 days later and LESs harvested. LESs, were evaluated with trichrome and hematoxylin and eosin (H&E) preparations. Results: Results for both trichrome and H&E slides were the same: severe inflammation in groups 2 and 3 but only minimal inflammation in group 1 (p < 0.05) and mild fibrosis in groups 2 and 3 and none in group 1 (p < 0.05). Conclusions: Botulinum toxin injection and forced balloon dilatation caused significant inflammation in the esophagus of the swine, which would be consistent with the injury caused by reflux. Forced balloon dilatation and botulinum toxin caused fibrosis and may increase surgical risk.