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Journal of Natural Medicines

Erschienen in:

01.01.2007 | Original Paper

Evaluation of the antimalarial and antileishmanial activity of plants from the Greek island of Crete

verfasst von: N. Fokialakis, E. Kalpoutzakis, B. L. Tekwani, S. I. Khan, M. Kobaisy, A. L. Skaltsounis, S. O. Duke

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2007

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Abstract

Different parts of 65 plant species from the Greek island of Crete have been extracted and the 249 extracts obtained have been investigated for in-vitro antiprotozoal activity. Their activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum and Leishmania donovani promastigotes was determined. Their cytotoxicity on a mammalian kidney fibroblast (Vero) cell line was also tested. Dichloromethane and methanol extracts of Berberis cretica and methanol extracts of Cytinus hypocistis subsp. hypocistis, C. hypocistis subsp. orientalis, and C. ruber had significant activity against both strains of P. falciparum (IC₅₀<10 μg mL⁻¹). Dichloromethane extracts of Eryngium ternatum, Origanum dictamnus, and Origanum microphyllum, and the methanolic extract of Eryngium amorginum had significant activity against Leishmania donovani (IC₅₀<10 μg mL⁻¹). None of the extracts was cytotoxic.

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Titel: Evaluation of the antimalarial and antileishmanial activity of plants from the Greek island of Crete
verfasst von: N. Fokialakis
E. Kalpoutzakis
B. L. Tekwani
S. I. Khan
M. Kobaisy
A. L. Skaltsounis
S. O. Duke
Publikationsdatum: 01.01.2007
Verlag: Springer-Verlag
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2007
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-006-0013-y

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Evaluation of the antimalarial and antileishmanial activity of plants from the Greek island of Crete

Abstract

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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