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01.08.2009 | Original Article

Evaluation of utility of asymmetric index for count-based oxygen extraction fraction on dual-tracer autoradiographic method for chronic unilateral brain infarction

verfasst von: Katsuhiro Iwanishi, Hiroshi Watabe, Hiroshi Fujisaki, Takuya Hayashi, Yoshinori Miyake, Kotaro Minato, Masaki Naganuma, Toshiyuki Uehara, Chiaki Yokota, Hiroshi Moriwaki, Katsufumi Kajimoto, Kazuhito Fukushima, Kazuo Minematsu, Hidehiro Iida

Erschienen in: Annals of Nuclear Medicine | Ausgabe 6/2009

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Abstract

Objective

For diagnosing patients with ischemic cerebrovascular disease, non-invasive count-based method with ¹⁵O₂ and H ₂ ¹⁵ O positron-emission tomography (PET) data is widely used to measure asymmetric increases in oxygen extraction fraction (OEF). For shortening study time, we have proposed dual-tracer autoradiographic (DARG) protocol in which ¹⁵O₂ gas and C¹⁵O₂ gas are sequentially administrated within short period. In this paper, we evaluated feasibility of the non-invasive count-based method with the DARG protocol.

Methods

Twenty-three patients [67.8 ± 9.9 (mean ± SD) years] with chronic unilateral brain infarction were examined by the use of measurements of asymmetric OEF elevation. As DARG protocol, ¹⁵O₂ and C¹⁵O₂ gases were inhaled with 5-min interval and dynamic PET data were acquired for 8 min. Quantitative OEF (qOEF) image was computed with PET data and arterial input function. Ratio image of ¹⁵O₂ and C¹⁵O₂ phases of PET data was computed as count-based OEF (cbOEF) image. The asymmetric indices (AI) of qOEF (qOEF-AI) and cbOEF (cbOEF-AI) were obtained from regions of interest symmetric placed on left and right sides of cerebral hemisphere. To optimize the summation time of PET data for the cbOEF image, qOEF and cbOEF images with various summation times were compared.

Results

Image quality of cbOEF image was better than that of qOEF image. The best correlation coefficient of 0.94 was obtained when the cbOEF image was calculated from 0 to 180 s of ¹⁵O₂ summed image and 340 to 440 s of C¹⁵O₂ summed image.

Conclusion

Using the appropriate summation time, we obtained the cbOEF image with good correlation with qOEF image, which suggests non-invasive cbOEF image can be used for evaluating the degree of misery perfusion in patients with chronic unilateral brain infarction. The count-based method with DARG protocol has a potential to dramatically reduce the examination time of ¹⁵O PET study.

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Titel: Evaluation of utility of asymmetric index for count-based oxygen extraction fraction on dual-tracer autoradiographic method for chronic unilateral brain infarction
verfasst von: Katsuhiro Iwanishi
Hiroshi Watabe
Hiroshi Fujisaki
Takuya Hayashi
Yoshinori Miyake
Kotaro Minato
Masaki Naganuma
Toshiyuki Uehara
Chiaki Yokota
Hiroshi Moriwaki
Katsufumi Kajimoto
Kazuhito Fukushima
Kazuo Minematsu
Hidehiro Iida
Publikationsdatum: 01.08.2009
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 6/2009
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-009-0272-2

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Evaluation of utility of asymmetric index for count-based oxygen extraction fraction on dual-tracer autoradiographic method for chronic unilateral brain infarction

Abstract

Objective

Methods

Results

Conclusion

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Objective

Methods

Results

Conclusion

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