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01.01.2016 | Original Article

Exercise Improves Cognitive Impairment and Dopamine Metabolism in MPTP-Treated Mice

verfasst von: Aderbal S. Aguiar Jr., Samantha C. Lopes, Fabrine S. M. Tristão, Daniel Rial, Gisele de Oliveira, Cláudio da Cunha, Rita Raisman-Vozari, Rui D. Prediger

Erschienen in: Neurotoxicity Research | Ausgabe 1/2016

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Abstract

The classical motor symptoms of Parkinson’s disease (PD) are preceded by non-motor symptoms in preclinical stages, including cognition impairment. The current drug treatment for PD is palliative and does not meet the clinical challenges of the disease, such as levodopa-induced dyskinesia, non-motor symptoms, and neuroprotection. We investigated the neuroprotective and disease-modifying potential of physical exercise in a preclinical animal model of PD. C57BL/6 mice (adult males) ran on a horizontal treadmill for 6 weeks (moderate intensity, 5 times/week) and were treated intranasally with 65 mg/kg of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Exercise did not protect against MPTP-induced nigrostriatal neurodegeneration or frontostriatal dopamine depletion but decreased striatal dopamine turnover. Exercise also attenuated procedural and working memory impairment and D₂ receptor hypersensitivity in MPTP-treated mice. In summary, exercise improved dopaminergic neurotransmission and enhanced cognition in a preclinical animal model of PD.

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Titel: Exercise Improves Cognitive Impairment and Dopamine Metabolism in MPTP-Treated Mice
verfasst von: Aderbal S. Aguiar Jr.
Samantha C. Lopes
Fabrine S. M. Tristão
Daniel Rial
Gisele de Oliveira
Cláudio da Cunha
Rita Raisman-Vozari
Rui D. Prediger
Publikationsdatum: 01.01.2016
Verlag: Springer US
Erschienen in: Neurotoxicity Research / Ausgabe 1/2016
Print ISSN: 1029-8428
Elektronische ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-015-9566-4

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