nach oben

Digestive Diseases and Sciences

Erschienen in:

01.03.2009 | Original Article

Expression and Prognostic Value of ZNRD1 in Esophageal Squamous Cell Carcinoma

verfasst von: Yunping Zhao, Liu Hong, Ruwen Wang, Daiming Fan

Erschienen in: Digestive Diseases and Sciences | Ausgabe 3/2009

Einloggen, um Zugang zu erhalten

Abstract

The expression of ZNRD1 in esophageal cancer was first investigated by immunohistochemical analysis, RT-PCR and real-time PCR. The ZNRD1 antibody produced a consistently cytoplasmic staining pattern in all epithelial cells. The expression of ZNRD1 was statistically correlated with differentiation, depth of invasion, lymph node metastasis, pathological stage, lymphatic invasion, and vascular invasion. The survival rates of patients with ZNRD1-negative tumors tended to be statistically lower than those with ZNRD1-positive tumors. ZNRD1 expression was also confirmed to be down-regulated in esophageal cancer tissues compared to adjacent non-neoplastic tissues. The results showed that ZNRD1 might play an important role in esophageal carcinogenesis.

Hong L, Wang J, Zhao Y, Han Z, Zhou X, Guo W (2007) DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1. Cancer Invest 25(8):699–705. doi:10.1080/07357900701566304 PubMedCrossRef

Hong L, Chen Z, Zhang X, Xia L, Han Z, Lu Y (2006) Zinc ribbon domain containing 1 protein: modulator of multidrug resistance, tumorigenesis and cell cycle. Exp Oncol 28(4):258–262PubMed

Hong L, Qiao T, Han Y, Han S, Zhang X, Lin T (2006) ZNRD1 mediates resistance of gastric cancer cells to methotrexate by regulation of IMPDH2 and Bcl-2. Biochem Cell Biol 84(2):199–206. doi:10.1139/o05-173 PubMedCrossRef

Ando N, Ozawa S, Kitagawa Y, Shinozawa Y, Kitajima M (2000) Improvement in the results of surgical treatment of advanced squamous esophageal carcinoma during 15 consecutive years. Ann Surg 232:225–232. doi:10.1097/00000658-200008000-00013 PubMedCrossRef

Tabernero J, Macarulla T, Ramos FJ, Baselga J (2005) Novel targeted therapies in the treatment of gastric and esophageal cancer. Ann Oncol 16(11):1740–1748. doi:10.1093/annonc/mdi355 PubMedCrossRef

Hong L, Piao Y, Han Y, Wang J, Zhang X, Du Y (2005) Zinc ribbon domain-containing 1 (ZNRD1) mediates multidrug resistance of leukemia cells through regulation of P-glycoprotein and Bcl-2. Mol Cancer Ther 4(12):1936–1942. doi:10.1158/1535-7163.MCT-05-0182 PubMedCrossRef

Kuwano H, Nakajima M, Miyazaki T, Kato H (2003) Distinctive clinicopathological characteristics in esophageal squamous cell carcinoma. Ann Thorac Cardiovasc Surg 9(1):6–13PubMed

Hong L, Han Y, Han Y, Zhao Y, Zhang X, Qiao T (2007) Mechanisms of growth arrest by zinc ribbon domain-containing 1 (ZNRD1) in gastric cancer cells. Carcinogenesis 28(8):1622–1628. doi:10.1093/carcin/bgm064 PubMedCrossRef

Qian X, Jeon C, Yoon H, Agarwal K, Weiss MA (1993) Structure of a new nucleic-acid-binding motif in eukaryotic transcriptional elongation factor TFIIS. Nature 365:277–279. doi:10.1038/365277a0 PubMedCrossRef

10.

Hong L, Zhao Y, Wang J, Han Y, Guo W, Jin H (2008) Reversal of multidrug resistance of adriamycin-resistant gastric adenocarcinoma cells through the up-regulation of DARPP-32. Dig Dis Sci 53(1):101–107. doi:10.1007/s10620-007-9829-x PubMedCrossRef

11.

Hong L, Han Y, Shi R, Shao X, Sun L, Zhang Y (2005) ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase. Cancer Biol Ther 4(1):60–64. doi:10.1158/1535-7163.MCT-05-0182 PubMedCrossRef

12.

Hong L, Ning X, Shi Y, Shen H, Zhang Y, Lan M (2004) Reversal of multidrug resistance of gastric cancer cells by down-regulation of ZNRD1 with ZNRD1 siRNA. Br J Biomed Sci 61(4):206–210PubMed

13.

Hong L, Wang J, Han Y, Zhao Y, Gao J, Wang J (2007) Reversal of multidrug resistance of vincristine-resistant gastric adenocarcinoma cells through up-regulation of DARPP-32. Cell Biol Int 31(9):1010–1015. doi:10.1016/j.cellbi.2007.03.020 PubMedCrossRef

14.

Hong L, Zhang Y, Liu N, Liu C, Zhi M, Pan Y (2004) Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene. Biochem Biophys Res Commun 321(3):611–616. doi:10.1016/j.bbrc.2004.07.007 PubMedCrossRef

15.

Hong L, Zhang Y, Han S, Wang J, Shi Y, Pan Y (2004) Preparation and characterization of a novel monoclonal antibody specific to human ZNRD1 protein. Hybrid Hybridomics 23(1):65–68. doi:10.1089/153685904322772042 PubMedCrossRef

16.

Igaki H, Kato H, Tachimori Y, Nakanishi Y (2003) Prognostic evaluation of patients with clinical T1 and T2 squamous cell carcinomas of the thoracic esophagus after 3-field lymph node dissection. Surgery 133(4):368–374. doi:10.1067/msy.2003.76 PubMedCrossRef

17.

Ogata Y, Fujita H, Yamana H, Sueyoshi S, Shirouzu K (2003) Expression of vascular endothelial growth factor as a prognostic factor in node-positive squamous cell carcinoma in the thoracic esophagus: long-term follow-up study. World J Surg 27(5):584–589. doi:10.1007/s00268-003-6866-2 PubMedCrossRef

18.

Brucher BL, Becker K, Lordick F, Fink U, Sarbia M, Stein H (2006) The clinical impact of histopathologic response assessment by residual tumor cell quantification in esophageal squamous cell carcinomas. Cancer 106(10):2119–2127. doi:10.1002/cncr.21850 PubMedCrossRef

19.

Ikeda M, Natsugoe S, Ueno S, Baba M, Aikou T (2003) Significant host- and tumor-related factors for predicting prognosis in patients with esophageal carcinoma. Ann Surg 238(2):197–202PubMed

Titel: Expression and Prognostic Value of ZNRD1 in Esophageal Squamous Cell Carcinoma
verfasst von: Yunping Zhao
Liu Hong
Ruwen Wang
Daiming Fan
Publikationsdatum: 01.03.2009
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 3/2009
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-008-0380-1

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Expression and Prognostic Value of ZNRD1 in Esophageal Squamous Cell Carcinoma

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2009

Still No Meta-Analysis of Screening Colonoscopy for Colorectal Cancer?

The Relationship Between Updated Sydney System Score and LDL Cholesterol Levels in Patients Infected with Helicobacter pylori

MCM2 and MCM5 as Prognostic Markers in Colon Cancer: A Worthwhile Approach

Site Specific Delivery of Microencapsulated Fish Oil to the Gastrointestinal Tract of the Rat

A Novel Placement Method of the Bravo Wireless pH Monitoring Capsule for Measuring Intragastric pH

Therapeutic Results of Computed-Tomography-Guided Transcatheter Arterial Chemoembolization for Local Recurrence of Hepatocellular Carcinoma After Initial Transcatheter Arterial Chemoembolization: The Results of 85 Recurrent Tumors in 35 Patients

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin