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01.09.2008

Expression of Cytokine mRNA in Lymphocytes of Malnourished Children

verfasst von: Haydeé González-Martínez, Leonor Rodríguez, Oralia Nájera, David Cruz, Angel Miliar, Aarón Domínguez, Fausto Sánchez, Jaime Graniel, María Cristina González-Torres

Erschienen in: Journal of Clinical Immunology | Ausgabe 5/2008

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Abstract

Introduction

Protein–calorie malnutrition represents a significant worldwide health problem and is associated with an increased risk for infections. The purpose of this study was to evaluate possible changes in type 1/type 2 responses balance in malnourished children.

Results

The data obtained in the present study showed that the expression levels of tumor necrosis factor-α, interleukin (IL)-4, and IL-10 were more highly, in contrast IL-2, gamma interferon, and IL-6 genes were expressed less in all groups of malnourished children compared with the well-nourished infected children. It is important to indicate that the data collected in the present work agree with the results obtained by different authors, who showed differences in the production of cytokines in malnourished children.

Conclusion

In conclusion, the results suggest that alterations in the balance of type 1/type 2 immune responses exist in malnourished children, and this could be the reason that the immunological system of the malnourished children is incapable of eradicating infections.

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Titel: Expression of Cytokine mRNA in Lymphocytes of Malnourished Children
verfasst von: Haydeé González-Martínez
Leonor Rodríguez
Oralia Nájera
David Cruz
Angel Miliar
Aarón Domínguez
Fausto Sánchez
Jaime Graniel
María Cristina González-Torres
Publikationsdatum: 01.09.2008
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 5/2008
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-008-9204-5

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Abstract

Introduction

Results

Conclusion

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