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Journal of Assisted Reproduction and Genetics

Erschienen in:

01.04.2013 | ASSISTED REPRODUCTION TECHNOLOGIES

Failure of GnRH agonist-triggered oocyte maturation: its cause and management

verfasst von: Yoshimasa Asada, Fumiaki Itoi, Hiroyuki Honnma, Shuji Takiguchi, Noritaka Fukunaga, Yoshiki Hashiba, Tsuyoshi Baba, Toshiaki Endo

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 4/2013

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Abstract

Objective

In the present study we investigated the cause of GnRHa’s failure to trigger oocyte maturation and present an effective rescue protocol for use when failure occurs.

Design

Case reports.

Setting

One in vitro fertilization (IVF) center.

Patient(s)

Eight cases of failure of GnRH agonist (GnRHa)-triggered oocyte maturation and one case of GnRHa successfully triggered oocyte maturation, despite a weak response in the LH-RH test.

Main Outcome Measure(s)

All cases were successfully rescued by re-triggering maturation using HCG, with seven of the eight patients achieving ongoing pregnancy and successful delivery.

Result(s)

In three patients the cause of the oocyte maturation failure was likely temporal or continuous severe down-regulation of the hypothalamus-pituitary-axis, the cause was unknown in the other five patients.

Conclusion(s)

In cases where GnRHa fails to trigger oocyte maturation, a rescue protocol entailing re-triggering with HCG can produce successful outcomes.

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Titel: Failure of GnRH agonist-triggered oocyte maturation: its cause and management
verfasst von: Yoshimasa Asada
Fumiaki Itoi
Hiroyuki Honnma
Shuji Takiguchi
Noritaka Fukunaga
Yoshiki Hashiba
Tsuyoshi Baba
Toshiaki Endo
Publikationsdatum: 01.04.2013
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 4/2013
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-013-9966-4

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Failure of GnRH agonist-triggered oocyte maturation: its cause and management