First report of successful treatment for hemoglobin Bristol-Alesha by hemopoietic stem cell transplantation
- 01.12.2021
- Original Article
Erschienen in:
- Verfasst von
- Shanshan Li
- Kai Chen
- Can Huang
- Na Zhang
- Hui Jiang
- Shayi Jiang
- Erschienen in
- Annals of Hematology | Ausgabe 3/2022
Abstract
HBB gene mutations lead to many kinds of diseases, of which, except for the two most common diseases of thalassemia and sickle cell anemia, rare kinds of hemolytic anemia, such as hemoglobin Bristol-Alesha, are rarely reported, no ideal treatment in clinic. A child suffered from chronic recurrent hemolytic attacks and the related genes of hereditary hemolytic anemia were detected on her. Hematopoietic stem cell transplantation was conducted in the treatment of the patient. The patient was diagnosed as hemoglobin Bristol-Alesha and achieved complete recovery after hematopoietic stem cell transplantation. For Bristol-Alesha, without characteristic clinical manifestation and specific biochemical examination, diagnosis is dependent on the gene mutation detection and hematopoietic stem cell transplantation is an effective and curable method.
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- Titel
- First report of successful treatment for hemoglobin Bristol-Alesha by hemopoietic stem cell transplantation
- Verfasst von
-
Shanshan Li
Kai Chen
Can Huang
Na Zhang
Hui Jiang
Shayi Jiang
- Publikationsdatum
- 01.12.2021
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Annals of Hematology / Ausgabe 3/2022
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584 - DOI
- https://doi.org/10.1007/s00277-021-04721-7
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