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Inflammation Research
Erschienen in: Inflammation Research 5/2017

23.11.2016 | Review

G protein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis

verfasst von: Jinling Shu, Feng Zhang, Lingling Zhang, Wei Wei

Erschienen in: Inflammation Research | Ausgabe 5/2017

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Abstract

Introduction

G protein-coupled receptors (GPCRs) are transmembrane receptor proteins, which allow the transfer of signals across the membrane. Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and accompanied with inflammatory and abnormal immune response. GPCRs signaling pathways play a significant role in inflammatory and immune response processes including RA.

Findings

In this review, we have focused on the advances in GPCRs signaling pathway implicating the inflammatory and immune response of RA. The signaling pathways of GPCRs–adenylyl cyclase (AC)–cyclic adenosine 3′, 5′-monophosphate (cAMP) include β2 adrenergic receptors (β2-ARs)–AC–cAMP signaling pathways, E-prostanoid2/4 (EP2/4)–AC–cAMP signaling pathways and so on. Regulatory proteins, such as G protein-coupled receptor kinases (GRKs) and β-arrestins, play important modulatory roles in GPCRs signaling pathway. GPCRs signaling pathway and regulatory proteins implicate the pathogenesis process of inflammatory and immune response.

Conclusion

GPCRs–AC–cAMP signal pathways involve in the inflammatory and immune response of RA. Different signaling pathways are mediated by different receptors, such as β2-AR, PGE2 receptor, chemokines receptor, and adenosine receptor. GRKs and β-arrestins are crucial proteins in the regulation of GPCRs signaling pathways. The potential therapeutic targets as well as strategies to modulate GPCRs signaling pathway are new development trends.
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Metadaten
Titel
G protein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis
verfasst von
Jinling Shu
Feng Zhang
Lingling Zhang
Wei Wei
Publikationsdatum
23.11.2016
Verlag
Springer International Publishing
Erschienen in
Inflammation Research / Ausgabe 5/2017
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-016-1011-5

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