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International Journal of Colorectal Disease

Erschienen in:

20.06.2020 | Original Article

Gender aspects of survival after abdominoperineal resection for low rectal cancer: a retrospective study

verfasst von: Feng Bao, Jianying Shang, Chunhua Xiang, Guoqiang Li, Xing Zhi, Wen Liu, Dong Wang, Jianbo Xian-Yu, Zhigang Deng

Erschienen in: International Journal of Colorectal Disease | Ausgabe 11/2020

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Abstract

Purpose

The difference in prognosis between genders after abdominoperineal resection (APR) for low rectal cancer (LRC) is unclear. This study aimed to compare survival outcomes between genders in patients with LRC who underwent curative APR.

Methods

This retrospective cohort study used a database of consecutive colorectal resections. Patients who received curative APR with LRC were grouped according to their gender. Female patients were frequency-matched 1:1 on American Joint Committee on Cancer (AJCC) stage to male patients. Overall survival (OS), disease-free survival (DFS), and their independent risk factors were examined.

Results

A total of 140 patients with APR for LRC were included after matching: 70 (50.0%) males and 70 (50.0%) females. No significant differences were found between the groups in terms of age, operation methods, AJCC stage, and adjuvant therapy (all P > 0.05). Median follow-up was 39 (range: 3–128) months. Male gender was independently associated with worse OS (adjusted hazard ratio [HR] = 2.755, 95% CI: 1.507–5.038, P = 0.001) and worse DFS (adjusted HR = 2.440, 95% CI: 1.254–4.746, P = 0.009). Subgroup analysis revealed that female patients with stage III disease had better OS (P = 0.001) and DFS (P < 0.001) than male patients.

Conclusion

Gender affects survival after a curative APR for LRC. Compared with females, male patients with LRC after curative APR had worse prognosis, especially for stage III disease.

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Titel: Gender aspects of survival after abdominoperineal resection for low rectal cancer: a retrospective study
verfasst von: Feng Bao
Jianying Shang
Chunhua Xiang
Guoqiang Li
Xing Zhi
Wen Liu
Dong Wang
Jianbo Xian-Yu
Zhigang Deng
Publikationsdatum: 20.06.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: International Journal of Colorectal Disease / Ausgabe 11/2020
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-020-03671-2

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