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Irish Journal of Medical Science (1971 -)

Erschienen in:

30.11.2018 | Original Article

Gender impact on the correlations between Graves’ hyperthyroidism and hyperuricemia in Chinese

verfasst von: Xuehui Liu, Jianping Zhang, Zhaowei Meng, Qiang Jia, Jian Tan, Guizhi Zhang, Xue Li, Na Liu, Tianpeng Hu, Pingping Zhou, Qing Zhang, Kun Song, Qiyu Jia

Erschienen in: Irish Journal of Medical Science (1971 -) | Ausgabe 3/2019

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Abstract

Objective

An increased level of serum uric acid (SUA) can be observed in patients with hypothyroidism. Nonetheless, data on the relationship between hyperuricemia and hyperthyroidism was still controversial. Thus, we aimed to analyze the association between Graves’ hyperthyroidism and hyperuricemia in Chinese men and women.

Methods

We recruited 103 male and 254 female patients with Graves’ hyperthyroidism, as well as the same number of control subjects. Anthropometric measurements and fasting blood tests were collected and analyzed statistically by binary logistic regressions to determine the risk of developing hyperuricemia in hyperthyroidism.

Results

SUA levels in males were significantly higher than that in females in both patients and controls. SUA levels were also significantly increased in hyperthyroid patients compared to in controls in both genders. The incidence of hyperuricemia rose significantly in subjects with hyperthyroidism with a higher prevalence in males than in females. SUA was negatively correlated with age and fasting glucose in male hyperthyroid patients, while it was positively correlated with body height, body weight, free triiodothyronine, and free thyroxine in female patients. Hyperthyroidism was a risk factor for hyperuricemia with an odd ratio of 4.536 for men and 2.730 for women.

Conclusions

For hyperuricemia, hyperthyroidism was an important risk factor that should not be neglected, especially for men.

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Titel: Gender impact on the correlations between Graves’ hyperthyroidism and hyperuricemia in Chinese
verfasst von: Xuehui Liu
Jianping Zhang
Zhaowei Meng
Qiang Jia
Jian Tan
Guizhi Zhang
Xue Li
Na Liu
Tianpeng Hu
Pingping Zhou
Qing Zhang
Kun Song
Qiyu Jia
Publikationsdatum: 30.11.2018
Verlag: Springer London
Erschienen in: Irish Journal of Medical Science (1971 -) / Ausgabe 3/2019
Print ISSN: 0021-1265
Elektronische ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-018-1939-2

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Gender impact on the correlations between Graves’ hyperthyroidism and hyperuricemia in Chinese

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