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16.09.2022 | Original Article

Genetic diversity, reassortment, and recombination of mammalian orthoreoviruses from Japanese porcine fecal samples

verfasst von: Yuka Fukase, Fujiko Minami, Tsuneyuki Masuda, Toru Oi, Hitoshi Takemae, Hiroho Ishida, Hironobu Murakami, Naoyuki Aihara, Takanori Shiga, Junichi Kamiie, Tetsuya Furuya, Tetsuya Mizutani, Mami Oba, Makoto Nagai

Erschienen in: Archives of Virology | Ausgabe 12/2022

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Abstract

Mammalian orthoreoviruses (MRVs) are non-enveloped double-stranded RNA viruses with a broad host range. MRVs are prevalent worldwide, and in Japan, they have been isolated from various hosts, including humans, dogs, cats, wild boars, and pigs, and they have also been found in sewage. However, Japanese porcine MRVs have not been genetically characterized. While investigating porcine enteric viruses including MRV, five MRVs were isolated from the feces of Japanese pigs using MA104 cell culture. Genetic analysis of the S1 gene revealed that the Japanese porcine MRV isolates could be classified as MRV-2 and MRV-3. Whole genome analysis showed that Japanese porcine MRVs exhibited genetic diversity, although they shared sequence similarity with porcine MRV sequences in the DDBJ/EMBL/GenBank database. Several potential intragenetic reassortment events were detected among MRV strains from pigs, sewage, and humans in Japan, suggesting zoonotic transmission. Furthermore, homologous recombination events were identified in the M1 and S1 genes of Japanese porcine MRV. These findings imply that different strains of Japanese porcine MRV share a porcine MRV genomic backbone and have evolved through intragenetic reassortment and homologous recombination events.

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Titel: Genetic diversity, reassortment, and recombination of mammalian orthoreoviruses from Japanese porcine fecal samples
verfasst von: Yuka Fukase
Fujiko Minami
Tsuneyuki Masuda
Toru Oi
Hitoshi Takemae
Hiroho Ishida
Hironobu Murakami
Naoyuki Aihara
Takanori Shiga
Junichi Kamiie
Tetsuya Furuya
Tetsuya Mizutani
Mami Oba
Makoto Nagai
Publikationsdatum: 16.09.2022
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 12/2022
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-022-05602-8

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