Erschienen in:
01.12.2001 | Paper Report
Genetic susceptibility to antibody-mediated arthritis
verfasst von:
Frances Hall
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
The K/BxN model of murine inflammatory arthritis has provided exciting insights into this rheumatoid-like disease. The model emerged serendipitously from the intercross of T-cell receptor (TCR) transgenic mice x nonobese diabetic (NOD) mice (See Additional information [1]). Erosive arthritis occurred spontaneously in all the offspring. Arthritis was found to be intiated following recognition by the transgenic TCR of a glucose-6-phosphate isomerase (GPI) peptide, presented by the NOD class II molecule, I-Ag7. Transfer of serum from arthritic mice, containing anti-GPI antibodies was shown to induce arthritis in recipients, even if they were devoid of T and B cells. This paper explores the genetic basis for the variable susceptibility of different strains of inbred mice to serum-mediated arthritis. …