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Immunologic Research
Erschienen in: Immunologic Research 2-3/2013

01.07.2013 | ETIO PATHOGENESIS OF AUTOIMMUNITY

Genetics and autoantibodies

verfasst von: Carlo Perricone, Nancy Agmon-Levin, Fulvia Ceccarelli, Guido Valesini, Juan-Manuel Anaya, Yehuda Shoenfeld

Erschienen in: Immunologic Research | Ausgabe 2-3/2013

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Abstract

Autoimmune diseases (ADs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens. The pathogenic hypothesis comprises a complex interaction between genetic, environmental and hormonal factors that interact with an individual over time generating a dysregulation of the immune system leading to disease development. Several polymorphic genes contribute to the development of ADs. Furthermore, age and gender play a major role by influencing hormone levels that can represent the fulcrum unbalancing from susceptibility to protection. Evidences suggest that while all these steps occur, the susceptible individual develops autoantibodies over a long time lapse. Such autoantibody production is genetically determined and finally, their presence seems to determine the clinical presentation of ADs. The genetic predisposition to the developments of autoantibodies and toward the disease process may overlap. The unveiling of these mechanisms could allow not only to treat but also to prevent the development of autoimmune diseases.
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Metadaten
Titel
Genetics and autoantibodies
verfasst von
Carlo Perricone
Nancy Agmon-Levin
Fulvia Ceccarelli
Guido Valesini
Juan-Manuel Anaya
Yehuda Shoenfeld
Publikationsdatum
01.07.2013
Verlag
Springer-Verlag
Erschienen in
Immunologic Research / Ausgabe 2-3/2013
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-013-8396-9

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