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Der Nervenarzt
Erschienen in: Der Nervenarzt 5/2011

01.05.2011 | Übersichten

Genetische und hirnstrukturelle Anomalien bei Autismus-Spektrum-Störungen

Eine Brücke zum Verständnis der Ätiopathogenese?

verfasst von: Dr. T. Nickl-Jockschat, T.M. Michel

Erschienen in: Der Nervenarzt | Ausgabe 5/2011

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Zusammenfassung

Autismus-Spektrum-Störungen (ASD) sind tiefgreifende Entwicklungsstörungen mit hoher Heritabilität und bislang noch unbekannter Ätiopathogenese. Der molekulargenetischen Forschung ist es gelungen, mehrere Kandidatengene für die Erkrankung zu identifizieren, die funktionell in Verbindung zu Neurotransmission bzw. neuronaler Migration, kortikaler Organisation und synaptischer Plastizität stehen. Magnetresonanztomographische Studien konnten ein erhöhtes Hirnvolumen bei ASD-Patienten nachweisen. Vor allem die Frontal- und die Temporallappen waren im Volumen vergrößert. Am ausgeprägtesten war diese Volumenzunahme im frühen Kindesalter. Eine Kombination molekulargenetischer und strukturell-bildgebender Forschungsansätze erscheint als vielversprechend für die weitere Aufklärung der Ätiopathogenese der ASD.
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Metadaten
Titel
Genetische und hirnstrukturelle Anomalien bei Autismus-Spektrum-Störungen
Eine Brücke zum Verständnis der Ätiopathogenese?
verfasst von
Dr. T. Nickl-Jockschat
T.M. Michel
Publikationsdatum
01.05.2011
Verlag
Springer-Verlag
Erschienen in
Der Nervenarzt / Ausgabe 5/2011
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI
https://doi.org/10.1007/s00115-010-2989-5

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Psychobiosoziale Intervention bei Autismus

Historisches

War das psychiatrische Gutachten B. von Guddens über König Ludwig II. von Bayern korrekt?

Leitthema

Bildgebung bei Autismusspektrumstörungen

Neu in den Fachgebieten Neurologie und Psychiatrie

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

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