Erschienen in:
01.08.2011
Genotyping Gastric Cancer
verfasst von:
John Spiliotis
Erschienen in:
World Journal of Surgery
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Ausgabe 8/2011
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Excerpt
Gastric cancer, like most solid tumors, is associated with wide variations in mutation. This heterogeneity reveals the complexity of cancer and the major difficulties in predicting prognosis or treatment response among individual patients with the same clinicopathologic features, tumor staging, and treatment. Genotyping provides an exciting opportunity to identify the genetic variations, such as single-nucleotide polymorphisms (SNPs), underlying individual tumors. Such features may have clinical implications as prognostic and predictive markers. This raises the question of whether genotyping of key single genes, such as for example matrix metalloproteinase (MMP) genes, could be translated into clinically useful information. …