Background
Methods
Study design
Setting
Patients
Diagnostic test
Analytical procedures
Variables
Calculation of GFR
Iohexol-based mGFR
eGFR
Definition of AKI and ARC
Statistical analysis
Sample size
Demographics
Primary objective: AKI and ARC prevalence and severity
Secondary objective: performance of eGFR equations
Results
Patients
TOTAL | Neonates (< 28 days of age) | Children (> 28 days of age) | |
---|---|---|---|
Number of patients | 105 | 43 | 62 |
Male sex# | 64 (61%) | 24 (56%) | 40 (65%) |
Age: | |||
- Years† - Days† | 0.0 (0.0–17.2) 102 (0–6274) | 0.0 (0.0–0.1) 2 (0–27) | 6.1 (0.1–17.2) 2232 (31–6274) |
Weight (kg)* | 6.5 (3.5–29.8) | 3.5 (2.9–3.8) | 21.5 (8.2–40.0) |
Height (cm)* | 63 (51–133) | 51 (49–52) | 114 (73–152) |
Primary diagnosis# | |||
- Shock - Cardiovascular problems - Respiratory problems - Surgical problems or trauma - Central nervous system problems | 4 (3.8) 21 (20.0) 49 (46.7) 16 (15.2) 14 (13.3) | 0 (0.0) 7 (16.3) 26 (60.5) 8 (18.6) 2 (4.7) | 4 (6.5) 14 (22.6) 23 (37.1) 8 (12.9) 12 (19.4) |
-Sedation or pain management | 1 (1.0) | 0 (0.0) | 1 (1.6) |
Total PELOD-II score† | 5 (1–18) | 5 (2–16) | 5 (1–18) |
PRISM-III score† | - | - | 6 (0–26) |
PIM2 probability score† | - | - | 0.039 (0.016–0.98) |
SNAP-II-score† | - | 0 (0–68) | - |
Patients using vaso-active drugs# | 54 (51%) | 14 (32%) | 40 (65%) |
Patients using nephrotoxic drugs# | 51 (49%) | 16 (37%) | 35 (56%) |
Time between admission and start of study (h)* | 26 (16–52) | 28 (16–45) | 26 (16–56) |
Duration of total stay at ICU (h)* | 190 (101–300) | 181 (98–300) | 196 (104–304) |
AKI prevalence
ARC prevalence
Performance of eGFR equations
Median GFR (IQR) in ml/min/1.73 m2 | Median difference between eGFR and mGFR (IQR) in ml/min/1.73 m2 | P valueA | Accuracy (%) | |
---|---|---|---|---|
TOTAL | ||||
mGFR | 40.6 (26.4–92.9) | |||
eGFR-bedside | 69.2 (37.0–115.2) | 11.0 (0.69–36.7) | < 0.001 | 41.9 |
eGFR-Pierce | 59.7 (29.5–105.2) | 3.9 (− 6.0 to 20.5) | 0.002 | 59.4 |
CrCL | 71.1 (28.9–146.9) | 20.1 (− 4.7 to 57.0) | < 0.001 | 22.9 |
Children | ||||
mGFR | 80.7 (42.3–114.7) | |||
eGFR-bedside | 100.7(67.4–131.1) | 17.0 (− 4.6 to 49.3) | < 0.001 | 40.3 |
eGFR-Pierce | 89.8 (60.9–127.9) | 7.1 (− 10.5 to 30.0) | 0.016 | 50.0 |
CrCL | 116.4 (48.9–210.8) | 28.7 (5.6 to 88.1) | < 0.001 | 19.4 |
Neonates | ||||
mGFR# | 29.2 (22.3–35.0) | |||
eGFR-bedside# | 37.3 (26.9–51.9) | 9.9 (1.9–20.0) | < 0.001 | 44.2 |
eGFR-Pierce | 29.3 (21.0–41.3) | 2.0 (− 3.4 to 9.2) | 0.055 | 67.4 |
eGFR–Smeets# | 26.3 (18.9–36.5) | 0.0 (− 6.4 to 5.2) | 0.847 | 74.4 |
CrCL | 33.4 (23.4–58.7) | 7.3 (− 4.9 to 20.2) | 0.014 | 27.9 |