Erschienen in:
01.04.2010 | Case Report
Graft-versus-host disease-related polymyositis
verfasst von:
Helene Maillard-Lefebvre, Sandrine Morell-Dubois, Marc Lambert, Hilaire Charlanne, David Launay, Eric Hachulla, Ibrahim Yakoub-Agha, Pierre-Yves Hatron
Erschienen in:
Clinical Rheumatology
|
Ausgabe 4/2010
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Abstract
Chronic graft-versus-host disease (GVHD) sometimes mimics autoimmune diseases. We report the case of a 39-year-old patient who presented atypical polymyositis without elevated creatinine phosphokinase, related to a chronic GVHD following interruption of immunosuppressive treatment. Treatment with cyclosporine and corticosteroids resulted in complete and sustained remission of the polymyositis. The symptoms of chronic GVHD-related polymyositis are indistinguishable from those of idiopathic polymyositis. The context of transplantation and a decrease or interruption of prophylaxis suggest the diagnosis of GVHD-related polymyositis, especially if other manifestations of GVHD are associated. A suitably adapted treatment (association of corticotherapy and cyclosporine) improves polymyositis, and in most cases, a normal clinical state is achieved even if the symptoms were severe.