Introduction
Methods
Compliance with ethical standards
Subjects and assessments
Image acquisition
Image analysis
Confounding variables
Statistical analysis
Results
Structural covariance networks and aging
SCN | Voxels | MNI coordinates | Location | hem. | ||
---|---|---|---|---|---|---|
x
|
y
|
z
| ||||
a | 9488 | 2 | − 70 | 22 | Cuneal cortex | R |
1682 | 2 | 32 | 30 | Paracingulate gyrus | R | |
b | 7872 | 0 | 16 | 28 | Cingulate gyrus, anterior division | R |
1683 | − 34 | − 62 | − 4 | Occipital fusiform gyrus | L | |
1139 | − 34 | − 6 | 2 | Insular cortex | L | |
c | 6392 | − 2 | − 62 | 28 | Precuneus cortex | L |
1095 | 12 | − 66 | − 26 | Cerebellum (VI) | R | |
d | 15,580 | 10 | 14 | − 12 | Subcallosal cortex | R |
1484 | 28 | − 100 | 8 | Occipital pole | R | |
e | 10,442 | 40 | − 4 | − 40 | Inferior temporal gyrus, anterior division | R |
5355 | − 38 | 8 | − 38 | Temporal pole | L | |
1466 | 0 | 20 | 40 | Paracingulate gyrus | R | |
1313 | 10 | 38 | − 4 | Cingulate gyrus, anterior division | R | |
1106 | − 32 | 22 | − 4 | Insular cortex | L | |
f | 10,911 | 18 | − 4 | − 20 | Amygdala | R |
3841 | − 20 | − 4 | − 22 | Amygdala | L | |
1036 | 42 | − 22 | 56 | Postcentral gyrus | R | |
g | 17,295 | 30 | 46 | 20 | Frontal pole | R |
3753 | − 42 | − 72 | 24 | Lateral occipital cortex, superior division | L | |
3366 | 34 | − 66 | 20 | Lateral occipital cortex, superior division | R | |
h | 9650 | − 48 | − 26 | 16 | Parietal operculum cortex | L |
7478 | 50 | − 28 | 16 | Parietal operculum cortex | R | |
1028 | 10 | − 26 | 34 | Cingulate gyrus, posterior division | R | |
i | 5332 | 8 | 50 | 34 | Superior frontal gyrus | R |
4809 | − 8 | − 32 | 0 | Thalamus | L | |
1958 | − 42 | − 66 | 40 | Lateral occipital cortex, superior division | L | |
j | 6772 | 36 | − 24 | 56 | Postcentral gyrus | R |
5894 | − 40 | − 18 | 58 | Precentral gyrus | L | |
1687 | 30 | − 56 | − 32 | Cerebellum (VI) | R | |
1183 | 24 | − 34 | − 2 | Hippocampus | R | |
1016 | − 24 | − 22 | − 12 | Hippocampus | L | |
k | 8071 | 66 | − 34 | 10 | Superior temporal gyrus | R |
5038 | − 70 | − 26 | 8 | Superior temporal gyrus | L | |
2810 | − 54 | − 70 | − 36 | Cerebellum (crus I) | L | |
2500 | − 14 | 36 | 22 | Paracingulate gyrus | L | |
l | 23,648 | 2 | 44 | − 10 | Paracingulate gyrus | R |
1581 | 34 | − 98 | − 2 | Occipital pole | R | |
m | 11,130 | − 48 | − 54 | − 18 | Inferior temporal gyrus, temporooccipital part | L |
5891 | 44 | − 40 | − 32 | Cerebellum (crus I) | R | |
n | 4451 | 2 | 2 | 66 | Supplementary motor cortex | R |
4433 | − 38 | 22 | − 2 | Insular cortex | L | |
2532 | 2 | − 76 | 40 | Precuneus cortex | R | |
1843 | − 40 | − 58 | − 22 | Temporal occipital fusiform cortex | L | |
1115 | 40 | − 72 | − 20 | Cerebellum (crus I) | R |
SCN | Voxels | MNI coordinates | Location | hem. | ||
---|---|---|---|---|---|---|
x
|
y
|
z
| ||||
u | 15,844 | 2 | − 48 | − 50 | Cerebellum (right IX) | R |
1247 | 12 | − 38 | 48 | Precuneus | R | |
v | 4741 | − 42 | − 72 | − 44 | Cerebellum (crus II) | L |
2314 | 4 | 52 | − 28 | Frontal medial cortex | R | |
2022 | 44 | − 58 | − 52 | Cerebellum (VIIb) | R | |
w | 9773 | − 26 | − 88 | − 34 | Cerebellum (crus II) | L |
x | 15,801 | 42 | − 54 | − 42 | Cerebellum (crus I) | R |
y | 4618 | 10 | − 58 | − 54 | Cerebellum (right IX) | R |
2411 | 12 | − 42 | − 16 | Cerebellum (right I–IV) | R | |
z | 6105 | − 28 | − 78 | − 22 | Cerebellum (crus I) | L |
2357 | 16 | − 106 | 0 | Occipital pole | R |
Structural covariance network disintegration and cognition
Total memory | Figural memory | Verbal memory | Executive function | Fine motor skills | |
---|---|---|---|---|---|
SCN h | 1.56 (0.51; 2.35) | 10.8 (8.64; 13.04) | 0.23 (− 0.7; 1.14) | 1.47 (0.56; 2.87) | 15.08 (12.45; 17.35) |
SCN e | 4.95 (3.89; 6.51) | 3.64 (2.12; 5.59) | 6.44 (4.89; 8.12) | 2.61 (0.91; 4.1) | 5.99 (3.82; 7.93) |
SCN j | 0.12 (− 0.37; 0.56) | − 0.61 (− 1.29; 0.03) | − 0.54 (− 1.11; 0.03) | 1.85 (0.77; 3.14) | 9.6 (7.87; 11.34) |
SCN d | 1.47 (0.91; 2.05) | 3.24 (1.76; 4.73) | 0.43 (− 0.18; 1.03) | 1.58 (0.57; 2.42) | 3.2 (1.82; 4.41) |
SCN g | 0.07 (− 0.56; 0.56) | − 0.98 (− 1.63; − 0.3) | 2.82 (1.76; 3.66) | 3.11 (2.04; 4.39) | 1.29 (0.25; 2.35) |
SCN v | 0.12 (− 0.33; 0.48) | 0.33 (− 0.64; 1.13) | − 0.13 (− 0.53; 0.28) | 1.35 (0.32; 2.17) | 2.96 (1.61; 4.39) |
SCN i | 0.08 (− 0.65; 0.85) | 1.56 (0.13; 2.64) | − 0.56 (− 1.4; 0.25) | − 0.59 (− 1.27; 0.06) | 1.73 (0.59; 2.81) |
SCN a | 0.81 (0.35; 1.32) | 0.87 (0.01; 1.69) | 0.87 (0.14; 1.53) | − 0.12 (− 0.74; 0.57) | − 0.7 (− 1.49; 0.13) |
SCN w | 0.51 (− 0.04; 1.04) | 0.25 (− 0.62; 1.05) | 0.73 (− 0.1; 1.56) | − 0.17 (− 0.82; 0.45) | − 0.11 (− 0.93; 0.55) |
SCN x | − 0.15 (− 0.84; 0.45) | − 0.42 (− 1.31; 0.57) | − 0.41 (− 1.34; 0.45) | 0.01 (− 0.75; 0.83) | 1.39 (− 0.14; 3.06) |
SCN b | 0.14 (− 0.42; 0.57) | 0.19 (− 1.03; 1.27) | − 0.28 (− 1.01; 0.41) | 0.01 (− 0.67; 0.75) | − 0.83 (− 1.61; 0.09) |
SCN f | − 0.05 (− 0.49; 0.4) | 0.06 (− 0.73; 0.96) | 0.25 (− 0.51; 1.02) | − 0.51 (− 1.29; 0.31) | − 0.69 (− 1.41; − 0.02) |
SCN c | − 0.34 (− 0.75; 0.11) | − 0.77 (− 1.51; − 0.04) | 0 (− 0.68; 0.54) | 0.11 (− 0.59; 0.78) | − 0.69 (− 1.55; − 0.02) |
SCN u | − 0.3 (− 0.97; 0.19) | − 0.69 (− 1.53; 0.18) | − 0.05 (− 0.76; 0.56) | − 0.62 (− 1.43; 0.01) | − 0.79 (− 1.41; 0) |
Education | 52.7 (49.81; 55.84) | 44.82 (41.97; 48.65) | 56.51 (52.79; 61.11) | 51.22 (48.36; 54.42) | 15.02 (13.37; 17.24) |
Age | 37.24 (34.57; 40.6) | 36.72 (33.18; 39.78) | 29.42 (26.7; 31.95) | 37.18 (34.2; 39.83) | 46.29 (42.53; 50) |
Sex | 1.27 (0.61; 1.99) | 0.29 (− 0.72; 1.17) | 5.43 (3.98; 7.01) | − 0.25 (− 0.76; 0.4) | 0.31 (− 0.48; 1.05) |
WMH score | − 0.04 (− 0.66; 0.68) | 0.81 (− 0.29; 1.98) | − 0.29 (− 0.91; 0.21) | 0.53 (− 0.35; 1.34) | 1.38 (0.4; 2.17) |
Hypertension | 0.41 (− 0.19; 0.98) | 0.71 (− 0.24; 1.62) | − 0.15 (− 0.93; 0.53) | 0.3 (− 0.39; 0.98) | − 0.25 (− 0.87; 0.33) |
Lacunes | 0.06 (− 0.28; 0.41) | − 0.26 (− 0.63; 0.03) | 0.18 (− 0.2; 0.59) | 0.02 (− 0.16; 0.21) | − 0.04 (− 0.18; 0.1) |
nGBV | − 0.63 (− 1.38; − 0.1) | − 0.59 (− 1.53; 0.52) | − 0.88 (− 1.45; − 0.28) | 0.93 (− 0.19; 2.22) | − 0.15 (− 1.27; 0.98) |
Mediation analyses
N
| Total effect (c) | Direct effect (c′) | Indirect effect (ab) | Ratioa | Bootstrapped CI | |
---|---|---|---|---|---|---|
Total memory | ||||||
Temporal network (e) | 206 | − 0.5196 | − 0.4237 | − 0.0959 | 0.1845 |
− 0.1800, − 0.0279
|
Secondary somatosensory network (h) | 206 | − 0.5196 | − 0.4753 | − 0.0443 | 0.0852 | − 0.1264, 0.0315 |
Limbic network (d) | 206 | − 0.5196 | − 0.4813 | − 0.0383 | 0.0738 |
− 0.0867, − 0.0056
|
Cuneal network (a) | 206 | − 0.5196 | − 0.5461 | − 0.0265 | − 0.0509 | − 0.0032, 0.0751 |
Figural memory | ||||||
Secondary somatosensory network (h) | 206 | − 0.1612 | − 0.1234 | − 0.0378 | 0.2348 |
− 0.0741, − 0.0103
|
Temporal network (e) | 206 | − 0.1612 | − 0.1374 | − 0.0238 | 0.1477 | − 0.0513, 0.009 |
Limbic network (d) | 206 | − 0.1612 | − 0.1459 | − 0.0153 | 0.1048 |
− 0.0346, − 0.0020
|
Fronto-occipital network (i) | 206 | − 0.1612 | − 0.1543 | − 0.0069 | 0.0426 | − 0.0281, 0.0134 |
Cuneal network (a) | 206 | − 0.1612 | − 0.1693 | − 0.0081 | − 0.0505 | − 0.00046, 0.0307 |
Verbal memory | ||||||
Temporal network (e) | 206 | − 0.2474 | − 0.1953 | − 0.0521 | 0.2108 |
− 0.0996, − 0.0103
|
Fronto-parietal network (g) | 205 | − 0.2433 | − 0.2268 | − 0.0164 | 0.0675 | − 0.0409, 0.0010 |
Cuneal network (a) | 206 | − 0.2474 | − 0.2680 | 0.0206 | na |
0.0018, 0.0532
|
Executive functions | ||||||
Fronto-parietal network (g) | 213 | − 0.0311 | − 0.0275 | − 0.0036 | 0.1144 |
− 0.0074, − 0.0014
|
Temporal network (e) | 214 | − 0.0319 | 0.0270 | − 0.0048 | 0.1520 | − 0.0111, 0.0005 |
Sensorimotor network (j) | 214 | − 0.0319 | − 0.0297 | − 0.0022 | 0.0690 | − 0.0061, 0.0008 |
Limbic network (d) | 214 | − 0.0319 | − 0.0288 | − 0.0030 | 0.0955 |
− 0.0069, − 0.0001
|
Secondary somatosensory network (h) | 214 | − 0.0319 | − 0.0300 | − 0.0019 | 0.0598 | − 0.0076, 0.0035 |
Cerebellar network (v) | 214 | − 0.0319 | − 0.0295 | − 0.0024 | 0.0762 | − 0.0063, 0.0005 |
Fine motor skills | ||||||
Secondary somatosensory network (h) | 212 | − 0.3034 | − 0.2446 | − 0.0588 | 0.1938 |
− 0.1172, − 0.0115
|
Sensorimotor network (j) | 212 | − 0.3034 | − 0.2631 | − 0.0403 | 0.1328 |
− 0.0763, − 0.0161
|
Temporal network (e) | 212 | − 0.3034 | − 0.2450 | − 0.0583 | 0.1923 |
− 0.1061, − 0.0151
|
Limbic network (d) | 212 | − 0.3034 | − 0.2685 | − 0.0348 | 0.1148 |
− 0.0684, − 0.0122
|
Cerebellar network (v) | 212 | − 0.3034 | − 0.2745 | − 0.0289 | 0.0951 |
− 0.0613, − 0.0056
|
Fronto-occipital network (i) | 212 | − 0.3034 | − 0.2794 | − 0.0240 | 0.0790 | − 0.0580, 0.0004 |
Fronto-parietal network (g) | 211 | − 0.2982 | − 0.2779 | − 0.0204 | 0.0683 | − 0.0576, 0.0028 |