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01.10.2013 | Original Article

Growth and maturation improvement in children on renal replacement therapy over the past 20 years

verfasst von: Doris Franke, Stella Winkel, Jutta Gellermann, Uwe Querfeld, Lars Pape, Jochen H. H. Ehrich, Dieter Haffner, Leo Pavičić, Miroslav Živičnjak

Erschienen in: Pediatric Nephrology | Ausgabe 10/2013

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Abstract

Background

The attainment of normal growth and maturation remains a major challenge in the management of children and adolescents requiring renal replacement therapy (RRT).

Methods

We compared growth and maturation in 384 German children with RRT who were followed between 1998 and 2009 with 732 children who were enrolled in the European Dialysis and Transplant Association (EDTA) Registry from 1985 to 1988; of these children, 78 and 88 %, respectively, were transplanted.

Results

The data on the German patients included in the EDTA registry did not differ significantly from those of the patients from other European countries. Overall, the mean height standard deviation score (SDS) has improved over the past 20 years from −3.03 to −1.80 (p < 0.001). Until the age of 6 years, the difference in height SDS was not significant, whereas it improved significantly in adolescence (−3.40 vs. −1.52; p < 0.001). Significant improvements in the delay of the pubertal growth spurt, age at menarche, bone maturation and body mass index (BMI) were noted in the recent German group compared to the EDTA group (each p < 0.001).

Conclusions

Our findings demonstrate a marked improvement of growth and maturation in paediatric patients on RRT during the past 20 years.

Betts PR, Magrath G (1974) Growth pattern and dietary intake of children with chronic renal insufficiency. Br Med J 2:189–193PubMedCrossRef

Betts PR, White RH (1976) Growth potential and skeletal maturity in children with chronic renal insufficiency. Nephron 16:325–332PubMedCrossRef

Broyer M, Kleinknecht C, Loirat C, Marti-Henneberg C, Roy MP (1974) Growth in children treated with long-term hemodialysis. J Pediatr 84:642–649PubMedCrossRef

Schärer K, Chantler C, Brunner FP, Gurland HJ, Jacobs C, Parsons FM, Seyfart G, Wing AJ (1974) Combined report on regular dialysis and transplantation of children in Europe. Proc Eur Dial Transplant Assoc 12:65–108

Chantler C, Broyer M, Donckerwolcke RA, Brynger H, Brunner FP, Jacobs C, Kramer P, Selwood NH, Wing AJ (1981) Growth and rehabilitation of long-term survivors of treatment for end-stage renal failure in childhood. Proc Eur Dial Transplant Assoc 18:329–342PubMed

Henning P, Tomlinson L, Rigden SP, Haycock GB, Chantler C (1988) Long term outcome of treatment of end stage renal failure. Arch Dis Child 63:35–40PubMedCrossRef

Hokken-Koelega AC, van Zaal MA, van Bergen W, de Ridder MA, Stijnen T, Wolff ED, de Jong RC, Donckerwolcke RA, de Muinck Keizer-Schrama SM, Drop SL (1994) Final height and its predictive factors after renal transplantation in childhood. Pediatr Res 36:323–328PubMedCrossRef

Haffner D, Schaefer F, Nissel R, Wühl E, Tönshoff B, Mehls O (2000) Effect of growth hormone treatment on the adult height of children with chronic renal failure. German Study Group for growth hormone treatment in chronic renal failure. N Engl J Med 343:920–923CrossRef

Furth SL, Hwang W, Yang C, Neu AM, Fivush BA, Powe NR (2002) Growth failure, risk of hospitalization and death for children with end-stage renal disease. Pediatr Nephrol 17:450–455PubMedCrossRef

10.

Wong CS, Gipson DS, Gillen DL, Emerson S, Koepsell T, Sherrard DJ, Watkins SL, Stehman-Breen C (2000) Anthropometric measures and risk of death in children with end-stage renal disease. Am J Kidney Dis 36:811–919PubMedCrossRef

11.

Furth SL, Stablein D, Fine RN, Powe NR, Fivush BA (2002) Adverse clinical outcomes associated with short stature at dialysis initiation: a report of the North American pediatric renal transplant cooperative study. Pediatrics 109:909–913PubMedCrossRef

12.

Rizzoni G, Ehrich JHH, Brunner FP (1990) Combined report on regular dialysis and transplantation of children in Europe. Nephrol Dial Transplant 6:31–42

13.

Ehrich JH, Rizzoni G, Brunner FP, Brynger H, Geerlings W, Fassbinder W, Raine AE, Selwood NH, Tufveson G (1991) Combined report on regular dialysis and transplantation of children in Europe, 1989. Nephrol Dial Transplant 6:S37–S47

14.

Sempe M, Pedron G, Roy-Pernot MP (1979) Auxologie méthode et séquences. Theraplix, Paris

15.

Reinken L, van Oost G (1992) Longitudinal physical development of healthy children 0 to 18 years of age. Body length/height, body weight and growth velocity. Klin Padiatr 204:129–133PubMedCrossRef

16.

Tanner JM, Whitehouse R, Takaishi M (1966) Standards from birth to maturity for height, weight, height velocity and weight velocity: British children 1965. Arch Dis Child 41:454–471PubMedCrossRef

17.

Roede MJ, Wieringen JC (1985) Growth diagrams 1980 Netherlands third nation-wide survey. Tijdschr Soc Gezondheidsz Suppl 63:1–34

18.

de la Puente ML, Canela J, Alvarez J, Salleras L, Vicens-Calvet E (1997) Cross-sectional growth study of the child and adolescent population of Catalonia (Spain). Ann Hum Biol 24:435–452PubMedCrossRef

19.

Prader A, Largo RH, Molinari L, Issler C (1989) Physical growth of Swiss children from birth to 20 years of age. Helv Paediatr Acta Suppl 52:1–125PubMed

20.

Stolarczyk H, Malinowski A (1996) Secular changes of body height and mass in the children and adolescents of Lodz. Z Morphol Anthropol 81:167–177PubMed

21.

Kobyliansky E, Goldstein MS, Nathan H (1980) Longitudinal growth of Jewish children: the old Harvard Growth Study. Coll Anthropol 4:175–184

22.

Prebeg Z, Juresa V, Kujundzić M (1995) Secular growth changes in Zagreb schoolchildren over four decades, 1951–91. Ann Hum Biol 22:99–110PubMedCrossRef

23.

Wikland KA, Luo ZC, Niklasson A, Karlberg J (2002) Swedish population-based longitudinal reference values from birth to 18 years of age for height, weight and head circumference. Acta Paediatr 91:739–754PubMedCrossRef

24.

Greulich WW, Pyle SI (1959) Radiographic atlas of skeletal development of the hand and wrist, 2nd edn. Stanford University Press, Stanford

25.

Houang M, Cabrol S, Perin L, Ducos B, Bensman A, Le Bouc Y (2000) Insulin-like growth factor-I (IGF-I), insulin-like growth factor binding proteins (IGFBP) and insulin-like growth factor type I receptor in children with various status of chronic renal failure. Growth Hormon IGF Res 10:332–341CrossRef

26.

Abitbol CL, Warady BA, Massie MD, Baluarte HJ, Fleischman LE, Geary DF, Kaiser BA, McEnery PT, Chan JC (1990) Linear growth and anthropometric and nutritional measurements in children with mild to moderate renal insufficiency: a report of the growth failure in children with renal diseases study. J Pediatr 116:S46–S54PubMedCrossRef

27.

Harambat J, Cochat P (2009) Growth after renal transplantation. Pediatr Nephrol 24:1297–1306PubMedCrossRef

28.

Chkhotua AB, Klein T, Shabtai E, Yussim A, Bar-Nathan N, Shaharabani E, Lustig S, Mor E (2003) Kidney transplantation from living-unrelated donors: comparison of outcome with living-related and cadaveric transplants under current immunosuppressive protocols. Urology 62:1002–1006PubMedCrossRef

29.

Koo DD, Welsh KI, McLaren AJ, Roake JA, Morris PJ, Fuggle SV (1999) Cadaver versus living donor kidneys: impact of donor factors on antigen induction before transplantation. Kidney Int 56:1551–1559PubMedCrossRef

30.

Pape L, Ehrich JH, Zivicnjak M, Offner G (2005) Growth in children after kidney transplantation with living related donor graft or cadaveric graft. Lancet 366:151–153PubMedCrossRef

31.

Pape L, Ehrich JH, Zivicnjak M, Offner G (2006) Living related kidney donation as an advantage for growth of children independent of glomerular filtration rate. Transplant Proc 38:685–687PubMedCrossRef

32.

Grenda R, Watson A, Trompeter R, Tönshoff B, Jaray J, Fitzpatrick M, Murer L, Vondrak K, Maxwell H, van Damme-Lombaerts R, Loirat C, Mor E, Cochat P, Milford DV, Brown M, Webb NJ (2010) A randomized trial to assess the impact of early steroid withdrawal on growth in pediatric renal transplantation: the TWIST study. Am J Transplant 10:828–836PubMedCrossRef

33.

Höcker B, Weber LT, Feneberg R, Drube J, John U, Fehrenbach H, Pohl M, Zimmering M, Fründ S, Klaus G, Wühl E, Tönshoff B (2010) Improved growth and cardiovascular risk after late steroid withdrawal: 2-year results of a prospective, randomised trial in paediatric renal transplantation. Nephrol Dial Transplant 25:617–624PubMedCrossRef

34.

Fine RN, Martz K, Stablein D (2010) What have 20 years of data from the North American Pediatric Renal Transplant Cooperative Study taught us about growth following renal transplantation in infants, children, and adolescents with end-stage renal disease? Pediatr Nephrol 25:739–746PubMedCrossRef

35.

Offner G, Toenshoff B, Höcker B, Krauss M, Bulla M, Cochat P, Fehrenbach H, Fischer W, Foulard M, Hoppe B, Hoyer PF, Jungraithmayr TC, Klaus G, Latta K, Leichter H, Mihatsch MJ, Misselwitz J, Montoya C, Müller-Wiefel DE, Neuhaus TJ, Pape L, Querfeld U, Plank C, Schwarke D, Wygoda S, Zimmerhackl LB (2008) Efficacy and safety of basiliximab in pediatric renal transplant patients receiving cyclosporine, mycophenolate mofetil, and steroids. Transplantation 86:1241–1248PubMedCrossRef

36.

Yorgin PD, Belson A, Sanchez J, Al Uzri AY, Sarwal M, Bloch DA, Oehlert J, Salvatierra O, Alexander SR (2002) Unexpectedly high prevalence of posttransplant anemia in pediatric and young adult renal transplant recipients. Am J Kidney Dis 40:1306–1318PubMedCrossRef

37.

Kausman JY, Powell HR, Jones CL (2004) Anemia in pediatric renal transplant recipients. Pediatr Nephrol 19:526–530PubMedCrossRef

38.

Boehm M, Riesenhuber A, Winkelmayer WC, Arbeiter K, Mueller T, Aufricht C (2007) Early erythropoietin therapy is associated with improved growth in children with chronic kidney disease. Pediatr Nephrol 22:1189–1193PubMedCrossRef

39.

Greenbaum LA, Hidalgo G, Chand D, Chiang M, Dell K, Kump T, Peschansky L, Smith HK, Boyle M, Kopf M, Metz LC, Kamel M, Mahan JD (2008) Obstacles to the prescribing of growth hormone in children with chronic kidney disease. Pediatr Nephrol 23:1531–1535PubMedCrossRef

40.

Bosque M, Munian A, Bewick M, Haycock G, Chantler C (1983) Growth after renal transplants. Arch Dis Child 58:110–114PubMedCrossRef

41.

Grushkin CM, Fine RN (1973) Growth in children following renal transplantation. Am J Dis Child 125:514–516PubMed

42.

van Diemen-Steenvoorde R, Donckerwolcke RA, Brackel H, Wolff ED, de Jong MC (1987) Growth and sexual maturation in children after kidney transplantation. J Pediatr 110:351–356PubMed

43.

Turenne MN, Port FK, Strawderman RL, Ettenger RB, Alexander SR, Lewy JE, Jones CA, Agodoa LY, Held PJ (1997) Growth rates in pediatric dialysis patients and renal transplant recipients. Am J Kidney Dis 30:193–203PubMedCrossRef

44.

Danker-Hopfe H (1986) Menarcheal age in Europe. Yearb Phys Anthropol 29:81CrossRef

45.

Živičnjak M, Pavičić L (1996) Variation in menarcheal age according to the growth channels appertaination and the soft tissue component in pubertal girls. Coll Anthropol 20:353–363

46.

Loesch DZ, Hopper JL, Rogucka E, Huggins RM (1995) Timing and genetic rapport between growth in skeletal maturity and height around puberty: similarities and differences between girls and boys. Am J Hum Genet 56:753–759PubMed

Titel: Growth and maturation improvement in children on renal replacement therapy over the past 20 years
verfasst von: Doris Franke
Stella Winkel
Jutta Gellermann
Uwe Querfeld
Lars Pape
Jochen H. H. Ehrich
Dieter Haffner
Leo Pavičić
Miroslav Živičnjak
Publikationsdatum: 01.10.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 10/2013
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-013-2502-z

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Growth and maturation improvement in children on renal replacement therapy over the past 20 years

Abstract

Background

Methods

Results

Conclusions

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