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Reviews in Endocrine and Metabolic Disorders

Erschienen in:

08.10.2020

Growth hormone deficiency and replacement in children

verfasst von: Margaret C. S. Boguszewski

Erschienen in: Reviews in Endocrine and Metabolic Disorders | Ausgabe 1/2021

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Abstract

Growth hormone deficiency (GHD) is a rare but treatable cause of short stature. The diagnosis requires a careful evaluation of clinical history, physical examination and appropriate interpretation of longitudinal growth, with specific features for each period of life. Other clinical findings, in addition to growth failure, may be present and can be related to the etiology and to associated hormone deficiencies. Despite more than 50 years since the first reports of provocative tests of growth hormone (GH) secretion for the diagnosis of GHD, the interpretation of the results remains a matter of debate. When GHD is confirmed, GH treatment is recommended. Treatment is effective and safe, but requires daily injections during many years, which can affect adherence. At the end of longitudinal growth, during the transition phase, it might be necessary to re-evaluate GH secretion. This review summarizes and updates the recent information related to GHD in children, as well the recommendations for treatment.

Mehta S, Brar PC. Severe, persistent neonatal hypoglycemia as a presenting feature in patients with congenital hypopituitarism: a review of our case series. J Pediatr Endocrinol Metab. 2019;32(7):767–74.PubMedCrossRef

Cabrera-Salcedo C, Shah AS, Andrew M, Tyzinski L, Hwa V, Gutmark-Little I, et al. Isolated growth hormone deficiency due to the R183H mutation in GH1: clinical analysis of a four-generation family. Clin Endocrinol. 2017;87(6):874–6.CrossRef

Alatzoglou KS, Webb EA, Le Tissier P, Dattani MT. Isolated growth hormone deficiency (GHD) in childhood and adolescence: recent advances. Endocr Rev. 2014;35:376–432.PubMedCrossRef

Vasques GA, Andrade NLM, Correa FA, Jorge AAL. Update on new GH-IGF axis genetic defects. Arch Endocrinol Metab. 2019;63(6):608–17.PubMedCrossRef

Parks JS. Congenital Hypopituitarism. Clin Perinatol. 2018;45(1):75–91.PubMedCrossRef

Seckel HP. Concepts relating the pituitary growth hormone to somatic growth of the normal child. AMA J Dis Child. 1960;99:349–79.PubMed

Gluckman PD, Gunn AJ, Wray A, Cutfield WS, Chatelain PG, Guilbaud O, et al. Congenital idiopathic growth hormone deficiency associated with prenatal and early postnatal growth failure. J Pediatr. 1992;121(6):920–3.PubMedCrossRef

Mehta A, Hindmarsh PC, Stanhope RG, Turton JPG, Cole TJ, Preece MA, et al. The role of growth hormone in determining birth size and early postnatal growth, using congenital growth hormone deficiency (GHD) as a model. Clin Endocrinol. 2005;63(2):223–31.CrossRef

Wada K, Kobayashi H, Moriyama A, Haneda Y, Mushimoto Y, Hasegawa Y, et al. A case of an infant with congenital combined pituitary hormone deficiency and normalized liver histology of infantile cholestasis after hormone replacement therapy. Clin Pediatr Endocrinol. 2017;26(4):251–7.PubMedPubMedCentralCrossRef

10.

Boro H, Goyal A, Khadgawat R. Isolated growth hormone deficiency presenting with recurrent hypoglycaemia in a toddler. BMJ Case Rep. 2019;12(7):e231056.PubMedCrossRef

11.

Inoue H, Ihara K, Ochiai M, Takahata Y, Kohno H, Hara T. Congenital multiple pituitary hormone deficiency associated with hyperammonemia: a case report with a short review of the literature. J Perinatol. 2011;31(2):146–8.PubMedCrossRef

12.

Ueda Y, Aoyagi H, Tajima T. A newborn with combined pituitary hormone deficiency developing shock and sludge. J Pediatr Endocrinol Metab. 2017;30(12):1333–6.PubMedCrossRef

13.

Lee PA, Mazur T, Houk CP, Blizzard RM. Growth hormone deficiency causing micropenis: lessons learned from a well-adjusted adult. Pediatrics. 2018;142:e20174168.PubMedCrossRef

14.

Ranke MB, Schweizer R, Binder G. Basal characteristics and first year responses to human growth hormone (GH) vary according to diagnostic criteria in children with non-acquired GH deficiency (naGHD): observations from a single center over a period of five decades. J Pediatr Endocrinol Metab. 2018;31(11):1257–66.PubMed

15.

Collett-Solberg PF, Ambler G, Backeljauw PF, Bidlingmaier M, Biller BMK, Boguszewski MCS, et al. Diagnosis, genetics, and therapy of short stature in children: a growth hormone research society international perspective. Horm Res Paediatr. 2019;92(1):1–14.PubMedPubMedCentralCrossRef

16.

Blum WF, Klammt J, Amselem S, Pfäffle HM, Legendre M, Sobrier ML, et al. Screening a large pediatric cohort with GH deficiency for mutations in genes regulating pituitary development and GH secretion: frequencies, phenotypes and growth outcomes. EBioMedicine. 2018;36:390–400.PubMedPubMedCentralCrossRef

17.

Rothermel J, Reinehr T. Metabolic alterations in paediatric GH deficiency. Best Pract Res Clin Endocrinol Metab. 2016;30(6):757–70.PubMedCrossRef

18.

Cerbone M, Dattani MT. Progression from isolated growth hormone deficiency to combined pituitary hormone deficiency. Growth Hormon IGF Res. 2017;37:19–25.CrossRef

19.

Otto AP, França MM, Correa FA, Costalonga EF, Leite CC, Mendonca BB, et al. Frequent development of combined pituitary hormone deficiency in patients initially diagnosed as isolated growth hormone deficiency: a long term follow-up of patients from a single center. Pituitary. 2015;18(4):561–7.PubMedCrossRef

20.

Blum WF, Deal C, Zimmermann AG, Shavrikova EP, Child CJ, Quigley CA, et al. Development of additional pituitary hormone deficiencies in pediatric patients originally diagnosed with idiopathic isolated GH deficiency. Eur J Endocrinol. 2013;170(1):13–21.PubMedCrossRef

21.

Müller HL. Childhood-onset craniopharyngioma: state of the art of care in 2018. Eur J Endocrinol. 2019;180:R159–74.PubMedCrossRef

22.

Romano A, Rigante D, Cipolla C. Autoimmune phenomena involving the pituitary gland in children: new developing data about diagnosis and treatment. Autoimmun Rev. 2019;18(10):102363.PubMedCrossRef

23.

Copinschi G, Caufriez A. Sleep and hormonal changes in aging. Endocrinol Metab Clin N Am. 2013;42(2):371–89.CrossRef

24.

Verrillo A, Bizzarri C, Cappa M, Bruni O, Pavone M, Ferri R, et al. Sleep characteristics in children with growth hormone deficiency. Neuroendocrinology. 2011;94:66–74.PubMedCrossRef

25.

Muus JS, Weir FW, Kreicher KL, Bowlby DA, Discolo CM, Meyer TA. Hearing loss in children with growth hormone deficiency. Int J Pediatr Otorhinolaryngol. 2017;100:107–13.PubMedCrossRef

26.

Collett-Solberg PF, Jorge AAL, Boguszewski MCS, Miller BS, Choong CSY, Cohen P, et al. Growth hormone therapy in children; research and practice - a review. Growth Hormon IGF Res. 2019;44:20–32.CrossRef

27.

Wit JM, Kamp GA, Oostdijk W. on behalf of the Dutch working group on triage and diagnosis of growth disorders in children. Towards a rational and efficient diagnostic approach in children referred for growth failure to the general paediatrician. Horm Res Paediatr. 2019;91:223–40.PubMedCrossRef

28.

Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, et al. Guidelines for growth hormone and insulin-like growth factor-1 treatment in children and adolescents: growth hormone deficiency, idiopathic short stature, and primary insulin-like growth factor-1 deficiency. Horm Res Paediatr. 2016;86:361–97.PubMedCrossRef

29.

Chinoy A, Murray P. Diagnosis of growth hormone deficiency in the paediatric and transitional age. Best Pract Res Clin Endocrinol Metab. 2016;30(6):737–47.PubMedCrossRef

30.

Inoue-Lima TH, Vasques GA, Scalco RC, Nakaguma M, Mendonca BB, Arnhold IJP, et al. IGF-1 assessed by pubertal status has the best positive predictive power for GH deficiency diagnosis in peripubertal children. J Pediatr Endocrinol Metab. 2019;32(2):173–9.PubMedCrossRef

31.

Miller JD, Esparza A, Wright NM, Garimella V, Lai J, Lester SE, et al. Spontaneous growth hormone release in term infants: changes during the first four days of life. J Clin Endocrinol Metab. 1993;76(4):1058–62.PubMed

32.

Pagani S, Chaler EA, Radetti G, Travaglino P, Meazza C, Bozzola E, et al. Variations in biological and immunological activity of growth hormone during the neonatal period. Horm Res. 2007;68:145–9.PubMed

33.

Kurtoğlu S, Kondolot M, Mazıcıoğlu MM, Hatipoğlu N, Akın MA, Akyıldız B. Growth hormone, insulin like growth factor-1, and insulin-like growth factor-binding protein-3 levels in the neonatal period: a preliminary study. J Pediatr Endocrinol Metab. 2010;23(9):885–9.PubMedCrossRef

34.

Binder G, Weidenkeller M, Blumenstock G, Langkamp M, Weber K, Franz AR. Rational approach to the diagnosis of severe growth hormone deficiency in the newborn. J Clin Endocrinol Metab. 2010;95:2219–26.PubMedCrossRef

35.

Marin G, Domené HM, Barnes KM, Blackwell BJ, Cassorla FG, Cutler GB Jr. The effects of estrogen priming and puberty on the growth hormone response to standardized treadmill exercise and arginine-insulin in normal girls and boys. J Clin Endocrinol Metab. 1994;79(2):537–41.PubMed

36.

Lazar L, Phillip M. Is sex hormone priming in peripubertal children prior to growth hormone stimulation tests still appropriate? Horm Res Paediatr. 2010;73:299–302.PubMedCrossRef

37.

Müller G, Keller A, Reich A, Hoepffner W, Kratzsch J, Buckler JM, et al. Priming with testosterone enhances stimulated growth hormone secretion in boys with delayed puberty. J Pediatr Endocrinol Metab. 2004;17(1):77–83.PubMedCrossRef

38.

Yuen KCJ, Llahana S, Miller BS. Adult growth hormone deficiency: clinical advances and approaches to improve adherence. Expert Rev Endocrinol Metab. 2019 Nov;14(6):419–36.PubMedCrossRef

39.

Pampanini V, Pedicelli S, Gubinelli J, Scirè G, Cappa M, Boscherini B, et al. Brain magnetic resonance imaging as first-line investigation for growth hormone deficiency diagnosis in early childhood. Horm Res Paediatr. 2015;84:323–30.PubMedCrossRef

40.

Deal C, Hasselmann C, Pfäffle RW, Zimmermann AG, Quigley CA, Child CJ, et al. Associations between pituitary imaging abnormalities and clinical and biochemical phenotypes in children with congenital growth hormone deficiency: data from an international observational study. Horm Res Paediatr. 2013;79:283–92.PubMedCrossRef

41.

Kara Ö, Esen I, Tepe D, Gülleroğlu NB, Tayfun M. Relevance of pituitary gland magnetic resonance imaging results with clinical and laboratory findings in growth hormone deficiency. Med Sci Monit. 2018;24:9473–8.PubMedPubMedCentralCrossRef

42.

Penta L, Bizzarri C, Panichi M, Novelli A, Lepri FR, Cappa M, et al. Identification of a novel PROP1 mutation in a patient with combined pituitary hormone deficiency and enlarged pituitary. Int J Mol Sci. 2019;20(8):1875.PubMedCentralCrossRef

43.

Richmond E, Rogol AD. Treatment of growth hormone deficiency in children, adolescents and at the transitional age. Best Pract Res Clin Endocrinol Metab. 2016;30(6):749–55.PubMedCrossRef

44.

Stagi S, Scalini P, Farello G, Verrotti A. Possible effects of an early diagnosis and treatment in patients with growth hormone deficiency: the state of art. Ital J Pediatr. 2017;43(1):81.PubMedPubMedCentralCrossRef

45.

Çetinkaya S, Poyrazoğlu Ş, Baş F, Ercan O, Yıldız M, Adal E, et al. Response to growth hormone treatment in very young patients with growth hormone deficiencies and mini-puberty. J Pediatr Endocrinol Metab. 2018;31(2):175–84.PubMedCrossRef

46.

Allen DB, Backeljauw P, Bidlingmaier M, Biller BMK, Boguszewski MCS, Burman P, et al. GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults. Eur J Endocrinol. 2016;174(2):P1–9.PubMedCrossRef

47.

Graham S, Weinman J, Auyeung V. Identifying potentially modifiable factors associated with treatment non-adherence in paediatric growth hormone deficiency: a systematic review. Horm Res Paediatr. 2018;90:221–7.PubMedCrossRef

48.

Lal RA, Hoffman AR. Perspectives on long-acting growth hormone therapy in children and adults. Arch Endocrinol Metab. 2019;63(6):601–7.PubMedPubMedCentralCrossRef

49.

Miller BS, Velazquez E, Yuen KCJ. Long-acting growth hormone preparations – current status and future considerations. J Clin Endocrinol Metab. 2020;105(6):dgz149.PubMedCrossRef

50.

Child CJ, Zimmermann AG, Chrousos GP, Cummings E, Deal CD, Hasegawa T, et al. Safety outcomes during pediatric GH therapy: final results from the prospective GeNeSIS observational program. J Clin Endocrinol Metab. 2019;104(2):379–89.PubMedCrossRef

51.

Tamhane S, Sfeir JG, Kittah NEN, Jasim S, Chemaitilly W, Cohen LE, et al. GH therapy in childhood cancer survivors: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2018;103(8):2794–801.PubMedCrossRef

52.

Renes JS, Willemsen RH, Wagner A, Finken MJ, Hokken-Koelega AC. Bloom syndrome in short children born small for gestational age: a challenging diagnosis. J Clin Endocrinol Metab. 2013;98(10):3932–8.PubMedCrossRef

53.

Boguszewski CL, Boguszewski MCS. Growth Hormone's links to Cancer. Endocr Rev. 2019;40(2):558–74.PubMedCrossRef

54.

Clayton PE, Cuneo RC, Juul A, Monson JP, Shalet SM, Tauber M. Consensus statement on the management of the GH-treated adolescent in the transition to adult care. Eur J Endocrinol. 2005;152(2):165–70.PubMedCrossRef

55.

Sbardella E, Pozza C, Isidori AM, Grossman AB. Endocrinology and Adolescence: Dealing with transition in young patients with pituitary disorders. Eur J Endocrinol. 2019;181(4):R155–71.PubMedCrossRef

56.

Cavarzere P, Gaudino R, Sandri M, Ramaroli DA, Pietrobelli A, Zaffanello M, et al. Growth hormone retesting during puberty: a cohort study. Eur J Endocrinol. 2020;182(6):559–67.PubMedCrossRef

57.

Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, et al. American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of growth hormone deficiency in adults and patients transitioning from pediatric to adult care. Endocr Pract. 2019;25(11):1191–232.PubMedCrossRef

58.

Boguszewski CL, de Lacerda CS, de Lacerda FL, Carvalho JAR, Boguszewski MCS. Reappraisal of serum insulin-like growth factor-I (IGF-1) measurement in the detection of isolated and combined growth hormone deficiency (GHD) during the transition period. Arq Bras Endocrinol Metabol. 2013;57(9):709–16.PubMedCrossRef

Titel: Growth hormone deficiency and replacement in children
verfasst von: Margaret C. S. Boguszewski
Publikationsdatum: 08.10.2020
Verlag: Springer US
Erschienen in: Reviews in Endocrine and Metabolic Disorders / Ausgabe 1/2021
Print ISSN: 1389-9155
Elektronische ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-020-09604-2

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