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01.12.2017 | Research article | Ausgabe 1/2017 Open Access

BMC Pediatrics 1/2017

Growth of HIV-exposed uninfected, compared with HIV-unexposed, Zambian children: a longitudinal analysis from infancy to school age

Zeitschrift:
BMC Pediatrics > Ausgabe 1/2017
Autoren:
Anna Rosala-Hallas, Jonathan W. Bartlett, Suzanne Filteau
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12887-017-0828-6) contains supplementary material, which is available to authorized users.

Abstract

Background

Early growth of HIV-exposed, uninfected (HEU) children is poorer than that of their HIV-unexposed, uninfected (HUU) counterparts but there is little longitudinal or longer term information about the growth effects of early HIV exposure.

Methods

We performed a longitudinal analysis to compare growth of HEU and HUU infants and children using data from two cohort studies in Lusaka, Zambia. Initially 207 HUU and 200 HEU infants from the Breastfeeding and Postpartum Health (BFPH) study and 580 HUU and 165 HEU from the Chilenje Infant Growth, Nutrition and Infection Study (CIGNIS) had anthropometric measurements taken during infancy and again when school-aged, at which time 66 BFPH children and 326 CIGNIS children were available. We analysed the data from the two cohorts separately using linear mixed models. Linear regression models were used as a secondary analysis at the later time points, adjusting for breastfeeding duration. We explored when the main group differences in growth emerged in order to estimate the largest ‘effect periods’.

Results

After adjusting for socioeconomic status and maternal education, HEU children had lower weight-for-age, length-for-age and BMI-for-age Z-scores during early growth and these differences still existed when children were school-aged. Exposure group differences changed most between 1 and 6 weeks and between 18 months and ~7.5 years.

Conclusions

HEU children have poorer early growth than HUU children which persists into later growth. Interventions to improve growth of HEU children need to target pregnant women and infants.
Zusatzmaterial
Additional file 1: Table S1. Difference in mean Z-scores at later time points by maternal HIV status [95% CI] as estimated by regression models adjusted for socioeconomic status, maternal education and breast-feeding duration. (PDF 236 kb)
12887_2017_828_MOESM1_ESM.pdf
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