nach oben

Comparative Clinical Pathology

Erschienen in:

01.01.2016 | Original Article

Haematologic effects of leukoreduction on canine whole blood post-filtration and post-storage

verfasst von: Marcia Kikuyo Notomi, Rafael Ruiz de Gopegui, Pierre Barnabé Escodro

Erschienen in: Comparative Clinical Pathology | Ausgabe 1/2016

Einloggen, um Zugang zu erhalten

Abstract

Leukoreduction is the removal of leukocytes from a blood component to avoid the adverse reactions resulting from the exposure of leukocytes from a donor to the recipient during transfusion. A leukoreduced blood component has been defined as achieving a concentration of less than 5 × 10⁶ residual donor leukocytes per final blood product while maintaining 85 % of the original red blood cell count. In the present study, we evaluated the efficiency of leukocyte filtration using a BioR 01-plus blood filter (Fresenius Hemocare, Germany) on samples of whole blood in citrate-phosphate-dextrose-adenine (CPDA-1) anticoagulant from 21 dogs. The blood cell count, red blood cells (RBCs), white blood cells (WBCs) and platelets; haemoglobin concentration; packed cell volume (PCV); mean corpuscular volume (MCV); RBC distribution width (RDW); morphologic index (MI) and RBC morphology were evaluated pre-filtration, post-filtration and after storage for 28 days at 4 °C. After filtration, a significant reduction in leukocyte (98 %) and platelet (95.1 %) counts were observed, while the RBCs, haemoglobin concentration and PCV remained within the recommended levels; storage did not change these parameters.

Blasi B, D’Alessandro A, Ramundo N, Zolla L (2012) Red blood cell storage and cell morphology. Transfus Med 22:90–96. doi:10.1111/j.1365-3148.2012.01139.x CrossRefPubMed

Bowden RA, Slichter SJ, Sayers M, Weisdorf D, Cays M, Schoch G, Banaji M, Haake R, Welk K, Fisher L, McCullough J, Miller W (1995) A comparison of filtered leukocyte-reduced and cytomegalovirus (CMV) seronegative blood products for the prevention of transfusion-associated CMV infection after marrow transplant. Blood 86(9):3598–3603. doi:10.1182/blood-2002-10-3143 PubMed

Brownlee L, Wardrop JK, Sellon RK, Meyers KM (2000) Use of prestorage leucoreduction filter effectively removes leukocytes from canine whole blood while preserving red blood cell viability. J Vet Intern Med 14:412–417. doi:10.1111/j.1939-1676.2000.tb02249.x CrossRefPubMed

Bruil A, Beugeling T, Feijen J, van Aken WG (1995) The mechanisms of leukocyte removal by filtration. Transfus Med Rev 9(2):145–166. doi:10.1016/S0887-7963(05)80053-7 CrossRefPubMed

Callan MB, Patel RT, Rux AH, Bandyopadhyay S, Sireci AN, O’Donnell PA, Ruane T, Sikora T, Marryott K, Sachais BS, Hod EA (2013) Transfusion of 28-day-old leucoreduced or non-leucoreduced stored red blood cells induces an inflammatory response in healthy dogs. Vox Sang 105(4):319–327. doi:10.1111/vox.12058 CrossRefPubMedPubMedCentral

Dzik S, Aubuchon J, Jeffries L, Kleinman S, Manno C, Murphy ME, Popovsky MA, Sayers M, Silberstein LE, Slichter SJ, Vamvakas EC (2000) Leukocyte reduction of blood components: public policy and new technology. Transfus Med Rev 114(1):34–52. doi:10.1016/S0887-7963(00)80114-5 CrossRef

Ergül Ekiz E, Arslan M, Akyazi I, Eraslan Uygur E, Inal Gültekin G, Özcan M (2012) The effects of prestorage leukoreduction and storage duration on the in vitro quality of canine packed red blood cells. Turk J Vet Anim Sci 36(6):711–717. doi:10.3906/vet-1110-25

Fresenius K (2014) Transfusion technology: BioR and BioP filters. Fresenius Kabi Product Catalogue. Oberursel, Germany

Graf C, Raila J, Schweigert FJ, Kohn B (2012) Effect of leukoreduction treatment on vascular endothelial growth factor concentration in stored canine blood transfusion products. Am J Vet Res 73(12):2001–2006. doi:10.2460/ajvr.73.12.2001 CrossRefPubMed

Hohenhaus AE (2007) Transfusions containing red blood cells. Proceedings of the World Small Animal Veterinary Association WSAVA Congress, Sydney, Australia

Karger R, Lukow C, Kretschmer V (2011) The influence of maintaining the correct whole blood-to-anticoagulant ratio during donation on the quality of leukoreduced whole blood. Transfusion 51:1486–1492. doi:10.1111/j.1537-2995.2010.03030.x CrossRefPubMed

Karon BS, van Buskirk CM, Jaben EA, Hoyer JD, Thomas DD (2012) Temporal sequence of major biochemical events during blood bank storage of packed red blood cells. Blood Transfus 10:453–461. doi:10.2450/2012.0099-11 PubMedPubMedCentral

Kisielewicz C, Self IA (2014) Canine and feline blood transfusions: controversies and recent advances in administration practices. Vet Anaesth Analg 41(3):233–242. doi:10.1111/vaa.12135 CrossRefPubMed

Ledent E, Berlin G (1996) Factors influencing white cell removal from red cell concentrates by filtration. Transfusion 36:714–718. doi:10.1046/j.1537-2995.1996.36896374375.x CrossRefPubMed

McMichael MA, Smith SA, Galligan A et al (2010) Effect of leukoreduction on transfusion-induced inflammation in dogs. J Vet Intern Med 24(5):1131–1137. doi:10.1111/j.1939-1676.2010.0561.x CrossRefPubMed

Nagura Y, Tsuno NH, Tanaka M, Matsuhashi M, Takahashi K (2013) The effect of pre-storage whole-blood leukocyte reduction on cytokines/chemokines levels in autologous CPDA-1 whole blood. Transfus Apher Sci 49(2):223–230. doi:10.1016/j.transci.2013.01.006 CrossRefPubMed

Slichter SJ, Fish D, Abrams VK, Gaur L, Nelson K, Bolgiano D (2005) Evaluation of different methods of leukoreduction of donor platelets to prevent alloimmune platelet refractoriness and induce tolerance in a canine transfusion model. Blood 105(2):847–854. doi:10.1182/blood-2003-08-2942 CrossRefPubMed

Smith JD, Leitman SF (2000) Filtration of RBC units: effect of storage time and temperature on filter performance. Transfusion 40:521–523. doi:10.1046/j.1537-2995.2000.40050521.x CrossRefPubMed

Sollberger T, Walter R, Brand B, Contesse J, Meredith DO, Reinhart WH (2002) Influence of prestorage leucocyte depletion and storage time on rheologic properties of erythrocyte concentrates. Vox Sang 82:191–197. doi:10.1046/j.1423-0410.2002.00167.x CrossRefPubMed

Wortham ST, Ortolano GA, Wenz BA (2003) Brief history of blood filtration: clot screens, microaggregate removal, and leukocyte reduction. Transfus Med Rev 17(3):216–222. doi:10.1016/S0887-7963(03)00023-3 CrossRefPubMed

Titel: Haematologic effects of leukoreduction on canine whole blood post-filtration and post-storage
verfasst von: Marcia Kikuyo Notomi
Rafael Ruiz de Gopegui
Pierre Barnabé Escodro
Publikationsdatum: 01.01.2016
Verlag: Springer London
Erschienen in: Comparative Clinical Pathology / Ausgabe 1/2016
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-015-2155-3

Springer Medizin

Haematologic effects of leukoreduction on canine whole blood post-filtration and post-storage

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2016

Ethanolic extract of Salvia officinalis alter vascular endothelial growth factor gene expression and its receptors in the mouse endometrium at preimplantation

Liver function, paraclinical tests, and mortality risk factors in pediatric liver transplant candidates

Serum bile acids concentration in captive black-tailed prairie dogs (Cynomys ludovicianus)

Silver nanoparticles affects the expression of biomarker genes mRNA in rainbow trout (Oncorhynchus mykiss)

Effects of sex and age on the osmotic stability of Sahel goat erythrocytes

Evaluation of the osteogenic potentials of the platelet-rich plasma and autologous cancellous bone grafts on ulna ostectomies of Nigerian local dogs

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie