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01.12.2017 | Research article | Ausgabe 1/2017 Open Access

BMC Medicine 1/2017

Health-related quality of life and psychological distress among cancer survivors in Southeast Asia: results from a longitudinal study in eight low- and middle-income countries

Zeitschrift:
BMC Medicine > Ausgabe 1/2017
Autor:
The ACTION Study Group
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12916-016-0768-2) contains supplementary material, which is available to authorized users.

Abstract

Background

A better understanding of health-related quality of life (HRQoL) and psychological distress in cancer survivors can raise awareness, promote the development of policies in cancer survivorship care, and facilitate better targeted use of limited resources in low- and middle-income countries (LMICs). The main objectives of this paper were therefore to assess HRQoL and the prevalence of psychological distress amongst cancer survivors in Southeast Asia and identify risk factors of these outcomes.

Methods

The ACTION study was a longitudinal study in eight LMICs in Southeast Asia with 5249 first time cancer survivors followed up at 1 year after diagnosis. HRQoL was assessed using the EORTC QLQ-C30 and EQ-5D. Psychological distress (anxiety and depression) was assessed using the Hospital Anxiety and Depression Scale. General linear models and multiple logistic regression were used to identify independent predictors of HRQoL and psychological distress.

Results

One year after diagnosis, the mean EORTC QLQ-C30 global health score for survivors was 66.2 out of 100 (SD 22.0), the mean index score on the EQ-5D was 0.74 (SD 0.23), 37% of survivors had at least mild levels of anxiety, and 46% showed at least mild levels of depression. Poorest HRQoL and highest prevalence of anxiety and depression were seen in patients with lung cancer and lymphomas, while highest scores and least psychological distress were seen in female patients with breast and cervical cancer. The most significant predictor of poor HRQoL and psychological distress outcomes was cancer stage at diagnosis. Age, co-morbidities, treatment, and several socioeconomic factors were associated with HRQoL and psychological distress.

Conclusions

Cancer survivors in LMICs in Southeast Asia have impaired HRQoL and substantial proportions have psychological distress. Patients with advanced cancer stages at diagnosis and those in a poor socioeconomic position were most at risk of such poor outcomes. Supportive interventions for cancer patients that address wider aspects of patient wellbeing are needed, as well as policies that address financial and other barriers to timely treatment.
Zusatzmaterial
Additional file 2: Table S1A. Demographic, socioeconomic and clinical characteristics of the study population by sex (n = 5249). Table S1B. Baseline demographic, socioeconomic, and clinical characteristics of the study population (n = 5249) and non-responders at 12 months (n = 2271). Table S2A. Health-related quality of life (HRQoL) and psychological distress 1 year after diagnosis. Presented for the most common cancer sites (more than 200 cases). Table S4A. Standardized betas of multiple linear regression analyses and logistic linear regression analyses evaluating the association of independent variables with HRQoL and psychological distress, for breast cancer patients (N = 1654). Table S4B. Standardized betas of multiple linear regression analyses and logistic linear regression analyses evaluating the association of independent variables with HRQoL and psychological distress, for cervix cancer patients (n = 598). Table S4C. Standardized betas of multiple linear regression analyses and logistic linear regression analyses evaluating the association of independent variables with HRQoL and psychological distress, for mouth and pharynx cancer patients (n = 571). Table S4D. Standardized betas of multiple linear regression analyses and logistic linear regression analyses evaluating the association of independent variables with HRQoL and psychological distress, for colorectal cancer patients (n = 552). Table S4E. Standardized betas of multiple linear regression analyses and logistic linear regression analyses evaluating the association of independent variables with HRQoL and psychological distress, for lung cancer patients (n = 226). Table S4F. Standardized betas of multiple linear regression analyses and logistic linear regression analyses evaluating the association of independent variables with HRQoL and psychological distress, for lymphoma patients (n = 241). (DOCX 91 kb)
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