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01.05.2019 | RADIOTHERAPY

High-dose intensity-modulated radiation therapy as primary treatment of prostate cancer: genitourinary/gastrointestinal toxicity and outcomes, a single-institution experience

verfasst von: Beatrice Detti, Muhammed Baki, Carlotta Becherini, Calogero Saieva, Daniele Scartoni, Irene Giacomelli, Laura Trombetta, Cristina Muntoni, Emanuela Olmetto, Giulio Francolini, Ana Turkaj, Juliana Topulli, Cinzia Ciabatti, Giulio Carta, Linda Poggesi, Camilla Delli Paoli, Francesca Terziani, Roberta Grassi, Lorenzo Livi

Erschienen in: La radiologia medica | Ausgabe 5/2019

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Abstract

Purpose

Prostatectomy, radiotherapy and watchful waiting are the main therapeutic options available for local stage of prostate cancer (PCa). We report our experience on 394 patients affected by prostate cancer primarily treated with high-dose, image-guided, IMRT, focusing on gastrointestinal, genitourinary toxicities and biochemical control.

Methods

From July 2003 to August 2014, 394 patients were treated with radical high-dose radiotherapy (HDRT) for prostate cancer; the mean total radiation dose was 79 Gy in standard fractions. Hormonal therapy (HT) was administered to 7.6% of low-risk patients, to 20.3% of intermediate-risk patients and to 72% of high-risk patients. Patients were evaluated for biochemical failure, local recurrence (LR) and metastases.

Results

Ninety-seven patients (26.65%) developed acute GU toxicity at the medium dose of 25.4 Gy, grade 1 (G1) or grade 2 (G2) in 94 cases. Only 16 patients (4.06%) reported chronic GU toxicity (G1 or G2), and one case developed G3 cystitis. No G3 GI acute and late toxicity were detected. Fifty-six (14.2%) patients experienced LR, 26 (6.6%) developed metastases and 70 patients (17.8%) were deceased. Gleason sum score > 7 was predictive for worse overall survival (GS = 7 was borderline) and for metastasis. No factors resulted predictive for local relapse. HT pre-RT had been demonstrated as a negative predictor for OS and DFS-DM.

Conclusions

Data confirm the safety of HDRT for PCa. Treatment was efficient with low toxicity profile. Moreover, continued technologic advancements, as image-guided radiotherapy, could lead to further reduction in toxicity, thus increasing the therapeutic index.

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Titel: High-dose intensity-modulated radiation therapy as primary treatment of prostate cancer: genitourinary/gastrointestinal toxicity and outcomes, a single-institution experience
verfasst von: Beatrice Detti
Muhammed Baki
Carlotta Becherini
Calogero Saieva
Daniele Scartoni
Irene Giacomelli
Laura Trombetta
Cristina Muntoni
Emanuela Olmetto
Giulio Francolini
Ana Turkaj
Juliana Topulli
Cinzia Ciabatti
Giulio Carta
Linda Poggesi
Camilla Delli Paoli
Francesca Terziani
Roberta Grassi
Lorenzo Livi
Publikationsdatum: 01.05.2019
Verlag: Springer Milan
Erschienen in: La radiologia medica / Ausgabe 5/2019
Print ISSN: 0033-8362
Elektronische ISSN: 1826-6983
DOI: https://doi.org/10.1007/s11547-018-0977-1

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High-dose intensity-modulated radiation therapy as primary treatment of prostate cancer: genitourinary/gastrointestinal toxicity and outcomes, a single-institution experience