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Indian Journal of Otolaryngology and Head & Neck Surgery

Erschienen in:

11.12.2023 | Original Article

Histologic and Histomorphometric Comparative Study of Oral Lichen Planus Versus Oral Lichenoid Reaction

verfasst von: Narges Ghazi, Nasrollah Saghravanian, Majid Mirhashemi, Hamidreza Shahabi

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Ausgabe 2/2024

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Abstract

Aim

Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory disease classified as an oral potentially malignant disorder (OPMD) and increased transformation risk to oral cancer. Oral lichenoid reactions (OLRs) share the clinical manifestations of OLP. This study aimed to determine histomorphometric changes in OLPs and OLRs in comparison to the healthy control, which helps to plan for the establishment of diagnostic criteria.

Materials and Methods

This cross-sectional prospective study was conducted on a total of 75 tissue-embedded paraffin-block samples, including OLPs (n = 25), OLR cases (n = 25), and healthy control individuals (n = 25). The study groups were compared by chi-squared, Fisher’s exact, and one-way ANOVA tests. A p-value less than 0.05 was considered statistically significant.

Results

Comparison of the nuclear area and cellular area showed a statistically significant difference between study groups in basal and parabasal layer (P < 0.05). Comparison of the nuclear-to-cytoplasm ratio showed a statistically significant difference between study groups in basal (P < 0.05) but not in the parabasal region (P = 0.681).

Conclusion

We showed a significant difference in the nuclear and cellular area, nuclear-to-cytoplasm ratio between OLPs and OLRs, and healthy controls, but there was no statistically significant difference between OLPs and OLRs. Thus, these parameters cannot be applied to differentiate diagnoses between OLPs and OLRs.

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Titel: Histologic and Histomorphometric Comparative Study of Oral Lichen Planus Versus Oral Lichenoid Reaction
verfasst von: Narges Ghazi
Nasrollah Saghravanian
Majid Mirhashemi
Hamidreza Shahabi
Publikationsdatum: 11.12.2023
Verlag: Springer India
Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe 2/2024
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-023-04411-y

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