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Reviews in Endocrine and Metabolic Disorders

Erschienen in:

01.06.2013

HIV and thyroid dysfunction

verfasst von: Alan A. Parsa, Amrit Bhangoo

Erschienen in: Reviews in Endocrine and Metabolic Disorders | Ausgabe 2/2013

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Abstract

Human Immunodeficiency virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS) are associated with dysfunction of many endocrine organs and their axis. HIV infectivity leads to altered metabolism, poor oral intake and increased prevalence of weight loss and wasting which may have a role in thyroid dysfunction. Overt thyroid dysfunction occurs at similar rates as the general population while subclinical disease such as nonthyroidal illness (sick euthyroid syndrome), subclinical hypothyroidism and isolated low T4 levels are more frequent. Moreover, HAART therapy can complicate thyroid function further through drug interactions and the immune reconstitution inflammatory syndrome (IRIS). In this review we report the common thyroid dysfunctions associated with HIV before and after HAART therapy. We discuss presentation, diagnostic work up, treatment and follow up in each condition.

Boelaert K, Franklyn JA. Thyroid hormone in health and disease. J Endocrinol. 2005;187:1–15.

Franklyn JA. The thyroid- too much and too little across the ages. The consequences of subclinical thyroid dysfunction. Clin Endocrinol. 2013;78(1):1–8.

Grunfeld C, Pang M, Doerrier W, et al. Indices of thyroid function and weight loss in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. Metabolism. 1993;42(10):1270–6.PubMedCrossRef

Olivieri A, Sorcini M, Battisti P, et al. Thyroid hypofunction related with the progression of human immunodeficiency virus infection. J Endocrinol Invest. 1993;16:407–13.PubMed

Kosmiski L. Energy expenditure in HIV infection. Am J Clin Nutr. 2011;94(6):16775–825.CrossRef

Mittelsteadt AL, Hileman CO, Harris SR, et al. Effects of HIV and antiretroviral therapy on resting energy expenditure in adult HIV-infected women—a matched, prospective, cross-sectional study. J Acad Nutr Diet. 2013. doi:10.1016/j.jand.2013.02.005.PubMed

Mangili A, Murman DH, Zampini AM, Wanke CA, Mayer KH. Nutrition and HIV infection: review of weight loss and wasting in the era of highly active antiretroviral therapy from the nutrition for healthy living cohort. Clin Infect Dis. 2006;42(6):836–42.PubMedCrossRef

Hirschfeld S, Laue L, Cutler Jr GB, Pizzo PA. Thyroid abnormalities in children infected with human immunodeficiency virus. J Pediatr. 1996;128(1):70–4.PubMedCrossRef

Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002;87(2):489.PubMedCrossRef

10.

Golden SH, Robinson KA, Saldanha I, et al. Prevalence and incidence of endocrine and metabolic disorders in the United Staes: a comprehensive review. J Clin Endocrinol Metab. 2009;94(6):1853–78.PubMedCrossRef

11.

Beltran S, Lescure F-X, Esper IE, et al. Subclinical hypothyroidism in HIV infected patients is not an autoimmune disease. Horm Res. 2006;66:21–6.PubMedCrossRef

12.

Madge S, Smith C, Lampe F, et al. No association between HIV disease and its treatment and thyroid function. HIV Med. 2006;7(supp 1):23. abstract P49.

13.

Noureldeen A, Qusti SY, Khoja GM. Thyroid function in newly diagnosed HIV-infected patients. Toxicol Ind Health. 2012. doi:10.1177/0748233712466133.PubMed

14.

Fundaro C, Olivieri A, Rendeli C, et al. Occurrence of anti-thyroid autoantibodies in children vertically infected with HIV-1. J Pediatr Endocrinol Metab. 1998;11(6):745–50.PubMedCrossRef

15.

Chiarelli F, Galli L, Verrotti A, et al. Thyroid function in children with perinatal human immunodeficiency virus type 1 infection. Thyroid. 2000;10(6):499–505.PubMed

16.

Rana S, Nunlee-Bland G, Valyasevi R, Iqbal M. Thyroid dysfunction in HIV-infected children: is L-thyroxine therapy beneficial? Pediatr AIDS HIV Infect. 1996;7(6):424–8.PubMed

17.

Marino R, Hegde A, Barnes KM, et al. Catch up growth after hypothyroidism is caused by delayed growth plate senescence. Endocrinology. 2008;149(4):1820–8.PubMedCrossRef

18.

Touzot M, Le Beller C, Touzot F, et al. Dramatic interaction between levothyroxine and lopinavir/ritonavir in an HIV infected patient. AIDS. 2006;20:1210–2.PubMedCrossRef

19.

Lanzafame M, Trevenzoli M, Faggian F, et al. Interaction between levothyroxine and indinavir in a patient with HIV infection. Infection. 2002;30(1):54–5.PubMedCrossRef

20.

Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: co-sponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012;11:1–207.

21.

Beltran S, Lescure F-X, Desailloud R, et al. Increased prevalence of hypothyroidism among human immunodeficiency virus- infected patients: a need for screening. Clin Infect Dis. 2003;37:579–83.PubMedCrossRef

22.

Merenich J, McDermott T, Asp A, et al. Evidence of endocrine involvement early in the course of human immunodeficiency virus infection. J Clin Endocrinol Metab. 1990;70:566–71.PubMedCrossRef

23.

Quirino T, Bongiovanni M, Ricci E, et al. Hypothyroidism in HIV-infected patients who have or have not received HAART. Clin Infect Dis. 2004;38(4):596–7.PubMedCrossRef

24.

Madeddu G, Spanu A, Chessa F, et al. Thyroid function in human immunodeficiency virus patients treathed with highly active antiretroviral therapy (HAART): a longitudinal study. Clin Endocrinol. 2006;64:375–83.

25.

Calza L, Manfredi R, Chiodo F. Subclinical hypothyroidism in HIV-infected patients receiving highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2002;31:361–2.PubMedCrossRef

26.

Bongiovanni M, Adorni F, Casana M, et al. Subclinical hypothyroidism in HIV-infected patients. J Antimicrob Chemother. 2006;58(5):1086–9.PubMedCrossRef

27.

Grappin M, Piroth L, Verges B, et al. Increased prevalence of subclinical hypothyroidism in HIV patients treated with highly active antiretroviral therapy. AIDS. 2000;14:1070–2.PubMedCrossRef

28.

Hoffman CJ, Brown TT. Thyroid function abnormalities in HIV-infected patients. Clin Infect Dis. 2007;45:488–94.CrossRef

29.

Sellmeyer DE, Grrunfeld C. Endocrine and metabolic disturbances in human immunodeficiency virus infection and the acquired immune deficiency syndrome. Endocr Rev. 1996;17:518–27.PubMed

30.

Dobs AS, Dempsy MA, Ladenson PW, Polk BF. Endocrine disorders in men infected with the human immunodeficiency virus. Am J Med. 1988;84:611–6.PubMedCrossRef

31.

Collazos J, Ibarra S, Mayo J. Thyroid hormones in HIV infected patients in the highly active antiretroviral therapy era: evidence of an interrelationship between the thyroid axis and the immune system. AIDS. 2004;17:763–5.CrossRef

32.

Vigano A, Riboni S, Bianchi R, et al. Thyroid dysfunction in antiretroviral treated children. Pediatr Infect Dis J. 2004;23(3):235–9.PubMedCrossRef

33.

Raffi F, Brisseau JM, Planchon et al. Endocrine function in 98 HIV- infected patients: a prospective study. AIDS. 1991;5:729–733

34.

Zavaschi AP, Maia AL, Goldani LA. Pneumocystis jiroveci thyroiditis: report of 15 cases in the literature. Mycoses. 2007;50(6):443–6.CrossRef

35.

Jinno S, Chang S, Jocobs MR. Coccidioides thyroiditis in an HIV-infected patient. J Clin Microbiol. 2012;50(7):2535–7.PubMedCrossRef

36.

Kiertiburanakul S, Sungkanuparph S, Malathum K, Pracharktam R. Concomitant tuberculous and cryptococcal thyroid abscess in a human immunodeficiency virus infected patient. Scand J Infect Dis. 2003;35(1):68–70.PubMedCrossRef

37.

Trzepacz PT, McCue M, Klein I, et al. Graves’ disease: an analysis of thyroid hormone levels and hyperthyroid signs and symptoms. Am J Med. 1989;87:558–61.PubMedCrossRef

38.

Bahn RS, Burch HB, Cooper DS, et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21(6):593–646.CrossRef

39.

Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N Engl J Med. 2003;348:2646–55.PubMedCrossRef

40.

Chen F, Day SL, Metcalfe RA, et al. Characteristics of autoimmune thyroid disease occurring as a late complication of immune reconstitution in patients with advanced human immunodeficiency virus (HIV) disease. Medicine. 2005;84(2):98–106.PubMedCrossRef

41.

Douek DC, McFarland RD, Keiser PH, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 1998;396:690–5.PubMedCrossRef

42.

Pakker NG, Notermans DW, de Boer RJ, et al. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nat Med. 1998;4(2):208.PubMedCrossRef

43.

Autran B, Carcelain G, Li TS, et al. Positive effects of combined antiretroviral therapy on CD + T cell homeostasis and function in advanced HIV disease. Science. 1997;277(5322):112–6.PubMedCrossRef

44.

Imami N, Antonopoulos C, Hardy GA, et al. Assessment of type 1 and type 2 cytokines in HIC type 1 infected individuals: impact of highly active antiretroviral therapy. AIDS Res Hum Retrovir. 1999;15:1499–508.PubMedCrossRef

45.

Mullur M, Wandel S, Colebunders R, et al. Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10(4):251–61.CrossRef

46.

Grant PM, Komarow L, Andersen J, et al. Risk factor analyses for immune reconstitution inflammatory syndrome in a randomized study of early vs. deferred ART during an opportunistic infection. PLoS One. 2010. 5(7). doi:10.1371/journal.pone.0011416

47.

Jubault V, Penfornis A, Schillo F, et al. Sequential occurance of thyroid autoantibodies and Graves disease after immune restoration in severely immunocompromised human immunodeficiency virus-1 infected patients. J Clin Endocrinol Metab. 2000;85:4254–7.PubMedCrossRef

48.

Vos F, Pieters G, Keuter M, van der Ven A. Graves’ disease during immune reconstitution in HIV infected patients treated with HAART. Scand J Infect Dis. 2006;38(2):124–6.PubMedCrossRef

49.

Sawin CT, Geller A, Wolf PA, et al. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med. 1994;331:1249–52.PubMedCrossRef

50.

Cappola AR, Fried LP, Arnold AM, et al. Thyroid status, cardiovascular risk, and mortality in older adults. JAMA. 2006;295:1033–41.PubMedCrossRef

51.

Cooper DS. Antithyroid drugs. N Engl J Med. 2005;352:905–917.

Titel: HIV and thyroid dysfunction
verfasst von: Alan A. Parsa
Amrit Bhangoo
Publikationsdatum: 01.06.2013
Verlag: Springer US
Erschienen in: Reviews in Endocrine and Metabolic Disorders / Ausgabe 2/2013
Print ISSN: 1389-9155
Elektronische ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-013-9248-6

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