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Current HIV/AIDS Reports

Erschienen in:

08.02.2019 | Central Nervous System and Cognition (SS Spudich, Section Editor)

HIV Eradication Strategies: Implications for the Central Nervous System

verfasst von: Rebecca T. Veenhuis, Janice E. Clements, Lucio Gama

Erschienen in: Current HIV/AIDS Reports | Ausgabe 1/2019

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Abstract

Purpose of Review

In addition to preventive protocols and antiretroviral therapy, HIV-1 eradication has been considered as an additional strategy to help fight the AIDS epidemic. With the support of multiple funding agencies, research groups worldwide have been developing protocols to achieve either a sterilizing or a functional cure for HIV-infection.

Recent Findings

Most of the studies focus on the elimination or suppression of circulating CD4+ T cells, the best characterized HIV-1 latent reservoir. The role of the central nervous system (CNS) as a latent reservoir is still controversial. Although brain macrophages and astrocytes are susceptible to HIV-1 infection, it has not been ascertained whether the CNS carries latent HIV-1 during cART and, if so, whether the virus can be reactivated and spread to other compartments after ART interruption.

Summary

Here, we examine the implications of HIV-1 eradication strategies on the CNS, regardless of whether it is a true latent reservoir and, if so, whether it is present in all patients.

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Titel: HIV Eradication Strategies: Implications for the Central Nervous System
verfasst von: Rebecca T. Veenhuis
Janice E. Clements
Lucio Gama
Publikationsdatum: 08.02.2019
Verlag: Springer US
Erschienen in: Current HIV/AIDS Reports / Ausgabe 1/2019
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI: https://doi.org/10.1007/s11904-019-00428-7

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HIV Eradication Strategies: Implications for the Central Nervous System

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