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Sleep and Breathing
Erschienen in: Sleep and Breathing 1/2019

05.09.2018 | Neurology • Original Article

HLA-DQB1*06:02 allele frequency and clinic-polysomnographic features in Saudi Arabian patients with narcolepsy

verfasst von: Saad M. Al Shareef, Eiman AlAnbay, Mujahed A. AlKhathlan, Zahid Shakoor, Mustafa Alnasser, Khalid D. Hamam, Adel S. Alharbi, Aljohara S. Almeneessier, Ahmed S. BaHammam

Erschienen in: Sleep and Breathing | Ausgabe 1/2019

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Abstract

Background

Narcolepsy is an uncommon neurological disorder characterised by irresistible spells of sleep associated with abnormal rapid eye movement (REM) sleep. The association between narcolepsy and human leukocyte antigen HLA- DQB1*06:02 has been established elsewhere but remains to be investigated among Saudi Arabian patients with narcolepsy.

Methods

A total of 29 Saudi patients with type I or type 2 narcolepsy comprising of 23 (79%) males and 6 (21%) females with a mean age of 17.2 ± 9.6 years were included in this study. Type 1 or type 2 narcolepsy was diagnosed by full polysomnography followed by a multiple sleep latency test in accordance with International Classifications of Sleep Disorders-3 criteria. HLA typing for DQB1 alleles was performed by polymerase chain reaction and hybridization with sequence-specific oligonucleotide probes. Differences in clinical and sleep parameters were compared by univariable analyses. HLA-DQB1*06:02 frequency was systematically compared with the published literature.

Results

Type 1 narcolepsy was diagnosed in 19/29 (65.5%) patients, whereas 10/29 (34.5%) patients had type 2 narcolepsy. DQB1*06:02 was present in 25/29 (86.2%) patients; 15/19 (78.9%) narcolepsy type 1 patients and 10/10 (100%) narcolepsy type 2 patients harboured the DQB1*06:02 allele. REM latency was significantly lower in DQB1*06:02-positive patients compared to DQB1*06:02-negative patients (17.6 ± 32.3 min vs. 106.0 ± 86.0 min; p = 0.025). Epworth Sleepiness Scale scores were significantly higher among type 1 than type 2 narcolepsy patients (19.7 ± 3.2 vs 15.3 ± 3.6; p = 0.02).

Conclusions

DQB1*06:02 allele frequencies among Saudi patients with narcolepsy were consistent with previously published data.
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Metadaten
Titel
HLA-DQB1*06:02 allele frequency and clinic-polysomnographic features in Saudi Arabian patients with narcolepsy
verfasst von
Saad M. Al Shareef
Eiman AlAnbay
Mujahed A. AlKhathlan
Zahid Shakoor
Mustafa Alnasser
Khalid D. Hamam
Adel S. Alharbi
Aljohara S. Almeneessier
Ahmed S. BaHammam
Publikationsdatum
05.09.2018
Verlag
Springer International Publishing
Erschienen in
Sleep and Breathing / Ausgabe 1/2019
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-018-1717-4

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