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International Journal of Legal Medicine

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20.02.2019 | Original Article

Hounsfield unit values of liver pathologies in unenhanced post-mortem computed tomography

verfasst von: Carmen Tisch, Eva Brencicova, Nicole Schwendener, Paolo Lombardo, Christian Jackowski, Wolf-Dieter Zech

Erschienen in: International Journal of Legal Medicine | Ausgabe 6/2019

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Abstract

Background

The goal of this study was to evaluate if unenhanced PMCT HU values of liver pathologies differ from post-mortem HU values of non-pathologic liver tissue.

Methods

Liver HU values were measured in five liver segments in PMCT unenhanced datasets of 214 forensic cases (124 male, 90 female, mean age 54.3 years). Liver HU values were compared with corresponding histologic liver findings. HU values of non-pathologic livers were compared to HU values of liver pathologies.

Results

A total of 64 non-pathologic livers (mean HU 58.32, SD 8.91) were assessed. Histologic diagnosed liver pathologies were as follows: steatosis (n = 121 (grade I n = 61, grade II n = 37, grade III n = 23)), fibrosis (n = 10), and cirrhosis (n = 19). HU values of the livers exhibiting severe steatosis (mean HU 32.44, SD 13.76), fibrosis (mean HU 44.7, SD 16.31), and cirrhosis (mean HU 50.59, SD 9.42) significantly differed to HU values of non-pathologic livers at ANOVA testing.

Conclusion

PMCT unenhanced liver HU value measurements may be used as an additional method to detect unspecific liver-pathology. Values below 30 HU may specifically indicate severe steatosis.

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Titel: Hounsfield unit values of liver pathologies in unenhanced post-mortem computed tomography
verfasst von: Carmen Tisch
Eva Brencicova
Nicole Schwendener
Paolo Lombardo
Christian Jackowski
Wolf-Dieter Zech
Publikationsdatum: 20.02.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: International Journal of Legal Medicine / Ausgabe 6/2019
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-019-02016-1

Neu im Fachgebiet Rechtsmedizin

Open Access 15.04.2024 | Biomarker | Schwerpunkt: Next Generation Pathology

Springer Medizin

Hounsfield unit values of liver pathologies in unenhanced post-mortem computed tomography

Abstract

Background

Methods

Results

Conclusion

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Background

Methods

Results

Conclusion

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