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International Urology and Nephrology

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14.02.2023 | Urology - Original Paper

How does Nephroblastomatosis impact the prognosis of unilateral Wilms tumor?

verfasst von: Xinyu Wang, Jiayi Li, Pei Liu, Jun Tian, Minglei Li, Ning Sun, Weiping Zhang, Hongcheng Song

Erschienen in: International Urology and Nephrology | Ausgabe 4/2023

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Abstract

Purpose

We aimed to explore whether Nephroblastomatosis (Nbm) has an effect on the prognosis of Wilms tumor (WT), and compare the relapse-free survival (RFS) and overall survival (OS) after surgery of WT patients with or without Nbm.

Methods

We retrospectively analyzed the clinical data of children with WT admitted to our department from April 2010 to September 2021. The enrolled patients were divided into two groups according to whether they were combined with Nbm histologically or not, the Nbm group for patients accompany with Nbm and the non-Nbm group for pure WT. All patients underwent a standardized comprehensive treatment according to National Wilms Tumor Study 5. Clinical variables, pathological results, and the prognosis were collected during follow-up.

Results

A total of 345 patients were finally enrolled in this study, of which 299 patients in the non-Nbm group and 46 patients in the Nbm group. Univariate Cox analysis revealed that Nbm was not the risk factor of either OS or RFS. The difference of postoperative RFS (P = 0.66) and OS (P = 0.68) between two groups was not significant. Subgroup analysis revealed that the RFS and OS between the non-Nbm group and the Nbm group had no statistical difference under the condition of same stage (low grade and high grade), same histology (favorable histology and unfavorable histology), same surgical approach (nephrectomy and nephron-sparing surgery), with or without lymph node metastasis (P > 0.05).

Conclusion

Although Nbm had a strong correlation with the occurrence of WT, a combined Nbm did not increase the risk of metastasis and poor prognosis of WT. After complete surgical resection followed by standardized treatment, the long-term RFS and OS were not different from pure WT.

IEC-C-006-A04-V.06 retrospectively registered.

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Titel: How does Nephroblastomatosis impact the prognosis of unilateral Wilms tumor?
verfasst von: Xinyu Wang
Jiayi Li
Pei Liu
Jun Tian
Minglei Li
Ning Sun
Weiping Zhang
Hongcheng Song
Publikationsdatum: 14.02.2023
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 4/2023
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-023-03493-5

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