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01.03.2004 | Leitthema

HPV-assoziierte Tonsillenkarzinome

Ein Update

verfasst von: PD Dr. J. P. Klussmann, S. Dinh, O. Guntinas-Lichius, C. Wittekindt, S. Weißenborn, U. Wieland, H. P. Dienes, T. Hoffmann, E. Smith, L. Turek, E. J. M. Speel, H. J. Pfister

Erschienen in: HNO | Ausgabe 3/2004

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Zusammenfassung

Etablierte Risikofaktoren für die Entwicklung von Kopf-Hals-Karzinomen sind der chronische Nikotin- und Alkoholkonsum. Zwar wurde schon länger vermutet, dass humane Papillomviren (HPV) ebenfalls eine Rolle spielen könnten, aber erst kürzlich veröffentlichte Studien geben eine ausreichende Grundlage, dass die Infektion mit onkogenen [High-risk- (HR-)] HPV als Risikofaktor für die Entwicklung von Kopf-Hals-Karzinomen anzusehen ist. Mindestens die Hälfte aller Tonsillenkarzinome enthalten HR-HPV. Für das Zervixkarzinom wurde die HPV-induzierte Karzinogenese intensiv untersucht, und zunehmend können Parallelen für das Tonsillenkarzinom nachgewiesen werden. Die vorliegende Übersicht stellt hierzu den aktuellen Wissensstand dar und fasst die bisher bekannten molekularbiologischen Aspekte hierzu zusammen. Die Abgrenzung der HPV-positiven Kopf-Hals-Karzinome gewinnt zunehmend an klinischer Bedeutung, da der HPV-Status der Karzinome sowohl Auswirkungen auf Risikofaktoren als auch auf die Prognose hat.

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Titel: HPV-assoziierte Tonsillenkarzinome
Ein Update
verfasst von: PD Dr. J. P. Klussmann
S. Dinh
O. Guntinas-Lichius
C. Wittekindt
S. Weißenborn
U. Wieland
H. P. Dienes
T. Hoffmann
E. Smith
L. Turek
E. J. M. Speel
H. J. Pfister
Publikationsdatum: 01.03.2004
Verlag: Springer-Verlag
Erschienen in: HNO / Ausgabe 3/2004
Print ISSN: 0017-6192
Elektronische ISSN: 1433-0458
DOI: https://doi.org/10.1007/s00106-004-1069-1

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Springer Medizin

HPV-assoziierte Tonsillenkarzinome

Ein Update

Zusammenfassung

Neu im Fachgebiet HNO

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

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Springer Medizin

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