Erschienen in:
01.09.2004 | Oral presentation
Hyper-ERAD: a novel pathomechanism for rheumatoid arthritis
verfasst von:
T Nakajima, N Yagishita, S Yamasaki, K Tsuchimochi, T Amano, A Fukamizu, I Maruyama, K Nishioka
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 3/2004
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Excerpt
Rheumatoid arthritis (RA) is a joint-affecting disease and is characterized with overgrowth of articular synovial cells, so-called 'pannus'. To understand the pathomechanism of RA, we attempted to characterize the rheumatoid synovial cell and found a novel protein, 'Synoviolin (synovial cell + protein)'. Structural analysis indicated that Synoviolin is an endoplasmic reticulum (ER)-resident E3 ubiquitin ligase, which is important for 'ER-associated degradation (ERAD)'. Its overexpression causes arthropathy, resembling RA in mice. Moreover, the heterozygote of Synoviolin (+/-) is remarkably resistant to collagen-induced arthritis. These 'gain of function' and 'loss of function' analyses clearly indicate the important role of Synoviolin in arthropathy. …