Erschienen in:
01.01.2015 | Brief Report
Identification and full-length molecular characterization of rare hepatitis C virus genotype 5a from India
verfasst von:
Manish Chandra Choudhary, Ekta Gupta, Priyanka Pandey, Vidhya Natarajan, Shvetank Sharma, Chitranshu Vashishtha, Manoj Kumar Sharma, Syed N. Kazim, Shiv K. Sarin
Erschienen in:
Archives of Virology
|
Ausgabe 1/2015
Einloggen, um Zugang zu erhalten
Abstract
This report presents a molecular characterization of the complete genome of a rare hepatitis C virus (HCV) genotype (GT5a) from India. Sequence homology of full genome revealed that the strain belonged to HCV GT5a. To trace the origin of this virus and to understand its evolutionary pattern, a phylogenetic reconstruction was carried out on full HCV genome sequences using Bayesian coalescent methods. The phylogenetic tree reconstruction revealed genotypic divergence, with formation of distinct clades. This analysis revealed that HCV genotype 5 might have originated from HCV genotype 3, as they have a recent common ancestor.