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Basic Research in Cardiology
Erschienen in: Basic Research in Cardiology 1/2017

01.01.2017 | Original Contribution

Identification of cardiovascular risk factors associated with bone marrow cell subsets in patients with STEMI: a biorepository evaluation from the CCTRN TIME and LateTIME clinical trials

verfasst von: Ariadna Contreras, Aaron F. Orozco, Micheline Resende, Robert C. Schutt, Jay H. Traverse, Timothy D. Henry, Dejian Lai, John P. Cooke, Roberto Bolli, Michelle L. Cohen, Lem Moyé, Carl J. Pepine, Phillip C. Yang, Emerson C. Perin, James T. Willerson, Doris A. Taylor, For the Cardiovascular Cell Therapy Research Network (CCTRN)

Erschienen in: Basic Research in Cardiology | Ausgabe 1/2017

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Abstract

Autologous bone marrow mononuclear cell (BM-MNC) therapy for patients with ST-segment elevation myocardial infarction (STEMI) has produced inconsistent results, possibly due to BM-MNC product heterogeneity. Patient-specific cardiovascular risk factors (CRFs) may contribute to variations in BM-MNC composition. We sought to identify associations between BM-MNC subset frequencies and specific CRFs in STEMI patients. Bone marrow was collected from 191 STEMI patients enrolled in the CCTRN TIME and LateTIME trials. Relationships between BM-MNC subsets and CRFs were determined with multivariate analyses. An assessment of CRFs showed that hyperlipidemia and hypertension were associated with a higher frequency of CD11b+ cells (P = 0.045 and P = 0.016, respectively). In addition, we found that females had lower frequencies of CD11b+ (P = 0.018) and CD45+CD14+ (P = 0.028) cells than males, age was inversely associated with the frequency of CD45+CD31+ cells (P = 0.001), smoking was associated with a decreased frequency of CD45+CD31+ cells (P = 0.013), glucose level was positively associated with the frequency of CD45+CD3+ cells, and creatinine level (an indicator of renal function) was inversely associated with the frequency of CD45+CD3+ cells (P = 0.015). In conclusion, the frequencies of monocytic, lymphocytic, and angiogenic BM-MNCs varied in relation to patients’ CRFs. These phenotypic variations may affect cell therapy outcomes and might be an important consideration when selecting patients for and reviewing results from autologous cell therapy trials.
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Metadaten
Titel
Identification of cardiovascular risk factors associated with bone marrow cell subsets in patients with STEMI: a biorepository evaluation from the CCTRN TIME and LateTIME clinical trials
verfasst von
Ariadna Contreras
Aaron F. Orozco
Micheline Resende
Robert C. Schutt
Jay H. Traverse
Timothy D. Henry
Dejian Lai
John P. Cooke
Roberto Bolli
Michelle L. Cohen
Lem Moyé
Carl J. Pepine
Phillip C. Yang
Emerson C. Perin
James T. Willerson
Doris A. Taylor
For the Cardiovascular Cell Therapy Research Network (CCTRN)
Publikationsdatum
01.01.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Basic Research in Cardiology / Ausgabe 1/2017
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI
https://doi.org/10.1007/s00395-016-0592-z

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