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Metabolic Brain Disease

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16.07.2018 | Review Article

IDO and TDO as a potential therapeutic target in different types of depression

verfasst von: Yanjie Qin, Nanxi Wang, Xinlin Zhang, Xuemei Han, Xuejia Zhai, Yongning Lu

Erschienen in: Metabolic Brain Disease | Ausgabe 6/2018

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Abstract

Depression is highly prevalent worldwide and a leading cause of disabilty. However, the medications currently available to treat depression fail to adequately relieve depressive symptoms for a large number of patients. Research into the aberrant overactivation of the kynurenine pathway and the production of various active metabolites has brought new insight into the progression of depression. IDO and TDO are the first and rate-limiting enzymes in the kynurenine pathway and regulate the production of active metabolites. There is substantial evidence that TDO and IDO enzyme are activated during depression, and therefore, IDO and TDO inhibitors have been identified as ideal therapeutic targets for depressive disorder. Hence, this review will focus on the kynurenine branch of tryptophan metabolism and describe the role of IDO and TDO in the pathology of depression. In addition, this review will compare the relative imbalance between KYNA and neurotoxic kynurenine metabolites in different psychiatric disorders. Finally, this review is also directed toward assessing whether IDO and TDO are potential therapeutic target in depression associated with other diseases such as diabetes and/or cancer, as well as the development of potent IDO and TDO inhibitors.

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Titel: IDO and TDO as a potential therapeutic target in different types of depression
verfasst von: Yanjie Qin
Nanxi Wang
Xinlin Zhang
Xuemei Han
Xuejia Zhai
Yongning Lu
Publikationsdatum: 16.07.2018
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 6/2018
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-018-0290-7

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