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01.12.2012 | Research | Ausgabe 1/2012 Open Access

Malaria Journal 1/2012

IgG responses to the gSG6-P1 salivary peptide for evaluating human exposure to Anopheles bites in urban areas of Dakar region, Sénégal

Zeitschrift:
Malaria Journal > Ausgabe 1/2012
Autoren:
Papa M Drame, Vanessa Machault, Abdoulaye Diallo, Sylvie Cornélie, Anne Poinsignon, Richard Lalou, Mbacké Sembène, Stéphanie Dos Santos, Christophe Rogier, Frédéric Pagès, Jean-Yves Le Hesran, Franck Remoué
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2875-11-72) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

PMD and VM participated in field surveys, assembled and analysed data and drafted the manuscript. AD participated in study coordination, field surveys and data collection. SC and AP participated in manuscript preparation, writing and revision. SD and RL coordinated the study and revised the manuscript. MS helped with manuscript preparation and revised the manuscript. JYH (participated also to the study coordination); CR and FP designed the study, helped with manuscript preparation and revised the manuscript. FR participated in study design, preparation and writing of the manuscript and revised the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Urban malaria can be a serious public health problem in Africa. Human-landing catches of mosquitoes, a standard entomological method to assess human exposure to malaria vector bites, can lack sensitivity in areas where exposure is low. A simple and highly sensitive tool could be a complementary indicator for evaluating malaria exposure in such epidemiological contexts. The human antibody response to the specific Anopheles gSG6-P1 salivary peptide have been described as an adequate tool biomarker for a reliable assessment of human exposure level to Anopheles bites. The aim of this study was to use this biomarker to evaluate the human exposure to Anopheles mosquito bites in urban settings of Dakar (Senegal), one of the largest cities in West Africa, where Anopheles biting rates and malaria transmission are supposed to be low.

Methods

One cross-sectional study concerning 1,010 (505 households) children (n = 505) and adults (n = 505) living in 16 districts of downtown Dakar and its suburbs was performed from October to December 2008. The IgG responses to gSG6-P1 peptide have been assessed and compared to entomological data obtained in or near the same district.

Results

Considerable individual variations in anti-gSG6-P1 IgG levels were observed between and within districts. In spite of this individual heterogeneity, the median level of specific IgG and the percentage of immune responders differed significantly between districts. A positive and significant association was observed between the exposure levels to Anopheles gambiae bites, estimated by classical entomological methods, and the median IgG levels or the percentage of immune responders measuring the contact between human populations and Anopheles mosquitoes. Interestingly, immunological parameters seemed to better discriminate the exposure level to Anopheles bites between different exposure groups of districts.

Conclusions

Specific human IgG responses to gSG6-P1 peptide biomarker represent, at the population and individual levels, a credible new alternative tool to assess accurately the heterogeneity of exposure level to Anopheles bites and malaria risk in low urban transmission areas. The development of such biomarker tool would be particularly relevant for mapping and monitoring malaria risk and for measuring the efficiency of vector control strategies in these specific settings.
Zusatzmaterial
Authors’ original file for figure 1
12936_2012_2050_MOESM1_ESM.pdf
Authors’ original file for figure 2
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Authors’ original file for figure 3
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Authors’ original file for figure 4
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Literatur
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